SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wai'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_B_THAB2_1
(LIVER
CARBOXYLESTERASE I)		 5wai ZINC FINGER PROTEIN
AEBP2
(Homo
sapiens) 		5 / 11 LEU C 477
LEU C 457
LEU C 415
LEU C 488
HIS C 418
 None
 1.26A 1mx1B-5waiC:
undetectable		 1mx1B-5waiC:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA507_0
(CHORISMATE SYNTHASE)		 5wai POLYCOMB PROTEIN
SUZ12
(Homo
sapiens) 		3 / 3 LEU B 455
ASN B 456
ARG B 121
 None
 0.79A 2qhfA-5waiB:
undetectable		 2qhfA-5waiB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_B_TP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 5wai POLYCOMB PROTEIN
SUZ12
(Homo
sapiens) 		5 / 12 PHE B 237
VAL B 301
PHE B 161
LEU B 184
SER B 233
 None
 1.48A 3apvB-5waiB:
undetectable		 3apvB-5waiB:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		 5wai POLYCOMB PROTEIN
SUZ12
(Homo
sapiens) 		5 / 12 GLY B 484
TYR B 478
ILE B 487
ALA B 444
LEU B 467
 None
 1.03A 3gwvA-5waiB:
undetectable		 3gwvA-5waiB:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_2
(ADENOSINE KINASE,
PUTATIVE)		 5wai POLYCOMB PROTEIN
SUZ12
(Homo
sapiens) 		4 / 5 LEU B  87
ALA B  89
PHE B  90
ASN B 435
 None
 1.25A 3uq6A-5waiB:
undetectable		 3uq6A-5waiB:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_A_ADNA401_2
(PUTATIVE ADENOSINE
KINASE)		 5wai POLYCOMB PROTEIN
SUZ12
(Homo
sapiens) 		4 / 4 LEU B  87
ALA B  89
PHE B  90
ASN B 435
 None
 1.22A 3vaqA-5waiB:
undetectable		 3vaqA-5waiB:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGK_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5wai POLYCOMB PROTEIN
SUZ12
(Homo
sapiens) 		3 / 3 VAL B 317
TYR B 315
GLN B 356
 None
 0.67A 5qgkA-5waiB:
undetectable		 5qgkA-5waiB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGK_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5wai POLYCOMB PROTEIN
SUZ12
(Homo
sapiens) 		3 / 3 VAL B 489
TYR B 430
GLN B 431
 None
 0.71A 5qgkA-5waiB:
undetectable		 5qgkA-5waiB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGR_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5wai POLYCOMB PROTEIN
SUZ12
(Homo
sapiens) 		3 / 3 VAL B 317
TYR B 315
GLN B 356
 None
 0.70A 5qgrA-5waiB:
undetectable		 5qgrA-5waiB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGR_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5wai POLYCOMB PROTEIN
SUZ12
(Homo
sapiens) 		3 / 3 VAL B 489
TYR B 430
GLN B 431
 None
 0.70A 5qgrA-5waiB:
undetectable		 5qgrA-5waiB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGT_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5wai POLYCOMB PROTEIN
SUZ12
(Homo
sapiens) 		3 / 3 VAL B 317
TYR B 315
GLN B 356
 None
 0.75A 5qgtA-5waiB:
undetectable		 5qgtA-5waiB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGT_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5wai POLYCOMB PROTEIN
SUZ12
(Homo
sapiens) 		3 / 3 VAL B 489
TYR B 430
GLN B 431
 None
 0.76A 5qgtA-5waiB:
undetectable		 5qgtA-5waiB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA503_1
(CYTOCHROME P450 2C9)		 5wai POLYCOMB PROTEIN
SUZ12
(Homo
sapiens) 		5 / 12 PHE B 165
LEU B 355
THR B 222
PRO B 217
LEU B 219
 None
 1.22A 5xxiA-5waiB:
undetectable		 5xxiA-5waiB:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNJ_A_NCTA402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 5wai POLYCOMB PROTEIN
SUZ12
(Homo
sapiens) 		4 / 7 TYR B 117
CYH B 450
CYH B 453
LEU B 467
 None
ZN  B1001 (-2.1A)
ZN  B1001 (-2.2A)
None
 1.36A 6cnjA-5waiB:
undetectable
6cnjB-5waiB:
undetectable		 6cnjA-5waiB:
22.09
6cnjB-5waiB:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNJ_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 5wai POLYCOMB PROTEIN
SUZ12
(Homo
sapiens) 		4 / 8 TYR B 117
CYH B 450
CYH B 453
LEU B 467
 None
ZN  B1001 (-2.1A)
ZN  B1001 (-2.2A)
None
 1.36A 6cnjD-5waiB:
undetectable
6cnjE-5waiB:
undetectable		 6cnjD-5waiB:
22.09
6cnjE-5waiB:
20.22