SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wan'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5wan PYRIMIDINE
MONOOXYGENASE RUTA
(Escherichia
coli) 		5 / 9 PHE A 218
VAL A 244
LEU A 330
PHE A  45
LEU A 316
 None
 1.45A 1wrkA-5wanA:
undetectable
1wrkB-5wanA:
undetectable		 1wrkA-5wanA:
12.16
1wrkB-5wanA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 5wan PYRIMIDINE
MONOOXYGENASE RUTA
(Escherichia
coli) 		4 / 6 LEU A 329
ASN A  65
GLN A 122
PHE A 206
 None
None
None
FMN  A 409 ( 4.5A)
 1.16A 2jn3A-5wanA:
undetectable		 2jn3A-5wanA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 5wan PYRIMIDINE
MONOOXYGENASE RUTA
(Escherichia
coli) 		5 / 12 ASN A  65
GLY A  11
SER A  48
PHE A   7
ILE A  50
 None
None
None
FMN  A 409 (-4.7A)
FMN  A 409 (-4.8A)
 1.07A 3k13A-5wanA:
8.0		 3k13A-5wanA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1002_1
(HEMOLYTIC LECTIN
CEL-III)		 5wan PYRIMIDINE
MONOOXYGENASE RUTA
(Escherichia
coli) 		3 / 3 ASP A 265
GLU A  60
GLY A  56
 None
GOL  A 408 (-4.2A)
None
 0.58A 3w9tA-5wanA:
undetectable		 3w9tA-5wanA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A83_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 5wan PYRIMIDINE
MONOOXYGENASE RUTA
(Escherichia
coli) 		5 / 12 GLY A 338
PHE A 332
LYS A 256
TYR A 309
LEU A 330
 None
 1.38A 4a83A-5wanA:
undetectable		 4a83A-5wanA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		 5wan PYRIMIDINE
MONOOXYGENASE RUTA
(Escherichia
coli) 		5 / 11 VAL A 319
ALA A 320
PHE A 242
SER A 238
GLY A 327
 None
 1.04A 4mm9A-5wanA:
undetectable		 4mm9A-5wanA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		 5wan PYRIMIDINE
MONOOXYGENASE RUTA
(Escherichia
coli) 		5 / 11 VAL A 319
ALA A 320
PHE A 242
SER A 238
GLY A 327
 None
 1.08A 4mmaA-5wanA:
undetectable		 4mmaA-5wanA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_A_29EA603_1
(TRANSPORTER)		 5wan PYRIMIDINE
MONOOXYGENASE RUTA
(Escherichia
coli) 		5 / 10 VAL A   6
ALA A  46
GLY A  14
PHE A 335
SER A  48
 None
None
None
GOL  A 406 (-4.9A)
None
 1.31A 4mmdA-5wanA:
undetectable		 4mmdA-5wanA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN)		 5wan PYRIMIDINE
MONOOXYGENASE RUTA
(Escherichia
coli) 		3 / 3 ARG A 141
GLU A 125
TYR A 137
 FMN  A 409 (-2.8A)
FMN  A 409 ( 4.8A)
None
 0.98A 4r29D-5wanA:
undetectable		 4r29D-5wanA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 5wan PYRIMIDINE
MONOOXYGENASE RUTA
(Escherichia
coli) 		5 / 12 THR A 119
ALA A 196
ALA A 228
GLY A 194
SER A 191
 FMN  A 409 ( 4.8A)
None
None
FMN  A 409 ( 3.7A)
FMN  A 409 (-2.5A)
 1.46A 5jglA-5wanA:
undetectable		 5jglA-5wanA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CJK_C_ACTC301_0
(IMMUNOGLOBULIN FAB
LIGHT CHAIN)		 5wan PYRIMIDINE
MONOOXYGENASE RUTA
(Escherichia
coli) 		4 / 4 VAL A 312
GLY A 307
ASP A 250
ASP A 247
 None
 1.31A 6cjkC-5wanA:
undetectable		 6cjkC-5wanA:
19.01