SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5was'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 5was HOMOSERINE KINASE
(Corynebacterium
glutamicum) 		6 / 12 LEU C 273
GLY A  30
ALA A  20
SER A  19
GLY A 101
LEU A 100
 None
None
None
None
PO4  A 401 (-4.0A)
None
 1.46A 1igxA-5wasC:
undetectable		 1igxA-5wasC:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5was HOMOSERINE KINASE
(Corynebacterium
glutamicum) 		5 / 12 GLY A  30
ALA A 168
SER A 152
GLY A  17
SER A 144
 None
 1.14A 1nbiA-5wasA:
undetectable		 1nbiA-5wasA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5was HOMOSERINE KINASE
(Corynebacterium
glutamicum) 		5 / 12 GLY A  30
ALA A 168
SER A 152
GLY A  17
SER A 144
 None
 1.16A 1nbiC-5wasA:
undetectable		 1nbiC-5wasA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5was HOMOSERINE KINASE
(Corynebacterium
glutamicum) 		5 / 12 GLY A  30
ALA A 168
SER A 152
GLY A  17
SER A 144
 None
 1.15A 1nbiD-5wasA:
undetectable		 1nbiD-5wasA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RI4_A_SAMA299_0
(MRNA CAPPING ENZYME)		 5was HOMOSERINE KINASE
(Corynebacterium
glutamicum) 		5 / 12 GLY A 101
GLY A  99
ALA A  20
SER A 144
GLN A  96
 PO4  A 401 (-4.0A)
PO4  A 401 ( 4.3A)
None
None
None
 0.89A 1ri4A-5wasA:
undetectable		 1ri4A-5wasA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_IMNA2001_1
(SERUM ALBUMIN)		 5was HOMOSERINE KINASE
(Corynebacterium
glutamicum) 		5 / 10 SER C 248
ALA C 261
ALA A 181
LEU C 294
LEU A 100
 None
 1.11A 2bxqA-5wasC:
undetectable		 2bxqA-5wasC:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_2
(PROTEASE)		 5was HOMOSERINE KINASE
(Corynebacterium
glutamicum) 		5 / 11 LEU A  62
VAL A  88
ILE A  72
VAL A  52
VAL A  50
 None
 1.09A 2nnpB-5wasA:
undetectable		 2nnpB-5wasA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_C_SVRC516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 5was HOMOSERINE KINASE
(Corynebacterium
glutamicum) 		5 / 9 PRO A  16
GLY C 300
ALA C 299
ALA A 149
LEU A  33
 None
 1.33A 3ur0C-5wasA:
undetectable		 3ur0C-5wasA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_K_CHDK103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5was HOMOSERINE KINASE
HOMOSERINE KINASE
HOMOSERINE KINASE
(Corynebacterium
glutamicum;
Corynebacterium
glutamicum;
Corynebacterium
glutamicum) 		5 / 11 ALA C 260
LEU C 273
LEU B 220
LEU A  29
LEU A  31
 None
 1.20A 4wg0I-5wasC:
undetectable
4wg0J-5wasC:
undetectable
4wg0K-5wasC:
undetectable		 4wg0I-5wasC:
undetectable
4wg0J-5wasC:
undetectable
4wg0K-5wasC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_B_ADNB302_1
(FLUORINASE)		 5was HOMOSERINE KINASE
(Corynebacterium
glutamicum) 		4 / 6 ASP A 139
THR A  28
THR A 154
SER A 152
 None
 1.47A 5b6iB-5wasA:
undetectable		 5b6iB-5wasA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_0
(METHYLTRANSFERASE)		 5was HOMOSERINE KINASE
(Corynebacterium
glutamicum) 		5 / 12 ALA A 107
VAL A 108
GLY A  75
ALA A  81
ALA A 114
 None
 1.07A 5n5dA-5wasA:
undetectable		 5n5dA-5wasA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_B_SAMB501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 5was HOMOSERINE KINASE
HOMOSERINE KINASE
(Corynebacterium
glutamicum;
Corynebacterium
glutamicum) 		5 / 12 LEU C 263
GLY A  99
SER A  19
LEU C 254
LEU A 182
 None
PO4  A 401 ( 4.3A)
None
None
None
 1.03A 5nfjB-5wasC:
undetectable		 5nfjB-5wasC:
undetectable