SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wat'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5wat HOMOSERINE KINASE
(Corynebacterium
glutamicum) 		5 / 12 GLY A  30
ALA A 168
SER A 152
GLY A  17
SER A 144
 None
 1.14A 1nbiC-5watA:
undetectable		 1nbiC-5watA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5wat HOMOSERINE KINASE
(Corynebacterium
glutamicum) 		5 / 12 GLY A  30
ALA A 168
SER A 152
GLY A  17
SER A 144
 None
 1.13A 1nbiD-5watA:
undetectable		 1nbiD-5watA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RI4_A_SAMA299_0
(MRNA CAPPING ENZYME)		 5wat HOMOSERINE KINASE
(Corynebacterium
glutamicum) 		5 / 12 GLY A 101
GLY A  99
ALA A  20
SER A 144
GLN A  96
 PO4  A 401 (-3.9A)
PO4  A 402 (-3.4A)
PO4  A 403 ( 4.4A)
None
None
 0.64A 1ri4A-5watA:
undetectable		 1ri4A-5watA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_D_T3D602_1
(TRANSTHYRETIN)		 5wat HOMOSERINE KINASE
(Corynebacterium
glutamicum) 		5 / 12 GLU A 172
ALA A 149
VAL A 151
LEU A  29
LEU A  22
 None
 1.13A 1sn5B-5watA:
undetectable
1sn5D-5watA:
undetectable		 1sn5B-5watA:
23.39
1sn5D-5watA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_D_T3D602_1
(TRANSTHYRETIN)		 5wat HOMOSERINE KINASE
(Corynebacterium
glutamicum) 		5 / 12 LEU A  29
LEU A  22
GLU A 172
ALA A 149
VAL A 151
 None
 1.11A 1sn5B-5watA:
undetectable
1sn5D-5watA:
undetectable		 1sn5B-5watA:
23.39
1sn5D-5watA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN0_A_TDZA501_1
(CYTOCHROME P450 2C8)		 5wat HOMOSERINE KINASE
(Corynebacterium
glutamicum) 		5 / 12 ILE A  72
LEU A 117
VAL A  88
VAL A  13
GLU A 305
 None
 1.10A 2vn0A-5watA:
undetectable		 2vn0A-5watA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		 5wat HOMOSERINE KINASE
(Corynebacterium
glutamicum) 		5 / 12 GLN A 237
ASP A  27
ASP A 139
ALA A  20
SER A  18
 None
PO4  A 403 (-3.7A)
None
PO4  A 403 ( 4.4A)
None
 1.15A 3d91B-5watA:
undetectable		 3d91B-5watA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_A_SAMA300_0
(PUTATIVE RRNA
METHYLASE)		 5wat HOMOSERINE KINASE
(Corynebacterium
glutamicum) 		5 / 12 THR A  28
GLY A  30
ASN A 140
ILE A 217
LEU A  22
 None
None
PO4  A 402 (-3.7A)
None
None
 1.11A 3eeyA-5watA:
undetectable		 3eeyA-5watA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_B_SAMB300_0
(PUTATIVE RRNA
METHYLASE)		 5wat HOMOSERINE KINASE
(Corynebacterium
glutamicum) 		5 / 12 THR A  28
GLY A  30
ASN A 140
ILE A 217
LEU A  22
 None
None
PO4  A 402 (-3.7A)
None
None
 1.10A 3eeyB-5watA:
undetectable		 3eeyB-5watA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_F_SAMF300_0
(PUTATIVE RRNA
METHYLASE)		 5wat HOMOSERINE KINASE
(Corynebacterium
glutamicum) 		5 / 12 THR A  28
GLY A  30
ASN A 140
ILE A 217
LEU A  22
 None
None
PO4  A 402 (-3.7A)
None
None
 1.14A 3eeyF-5watA:
undetectable		 3eeyF-5watA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 5wat HOMOSERINE KINASE
(Corynebacterium
glutamicum) 		4 / 4 LEU A 263
GLY A 265
GLY A 267
THR A 269
 None
PO4  A 402 ( 3.3A)
PO4  A 402 (-4.7A)
None
 0.95A 3si7A-5watA:
undetectable		 3si7A-5watA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FXS_A_MOAA702_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5wat HOMOSERINE KINASE
(Corynebacterium
glutamicum) 		5 / 9 ASP A 139
SER A  19
ASN A  21
GLY A 267
THR A 269
 None
None
PO4  A 403 (-3.2A)
PO4  A 402 (-4.7A)
None
 1.31A 4fxsA-5watA:
undetectable		 4fxsA-5watA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		 5wat HOMOSERINE KINASE
(Corynebacterium
glutamicum) 		5 / 11 THR A 247
LEU A 254
VAL A 293
ILE A 291
SER A 289
 None
 1.27A 4lhmA-5watA:
undetectable		 4lhmA-5watA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN)		 5wat HOMOSERINE KINASE
(Corynebacterium
glutamicum) 		5 / 12 ALA A  20
SER A  19
GLY A  99
ALA A 107
GLY A 136
 PO4  A 403 ( 4.4A)
None
PO4  A 402 (-3.4A)
None
MG  A 407 (-4.9A)
 1.29A 4r29A-5watA:
undetectable		 4r29A-5watA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		 5wat HOMOSERINE KINASE
(Corynebacterium
glutamicum) 		4 / 8 SER A  18
GLY A 101
ALA A 133
GLY A 136
 None
PO4  A 401 (-3.9A)
None
MG  A 407 (-4.9A)
 0.72A 5albL-5watA:
undetectable		 5albL-5watA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 5wat HOMOSERINE KINASE
(Corynebacterium
glutamicum) 		5 / 9 LEU A 283
ALA A 181
VAL A 183
ARG A 287
ALA A 286
 None
 1.49A 5g44A-5watA:
undetectable		 5g44A-5watA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_0
(METHYLTRANSFERASE)		 5wat HOMOSERINE KINASE
(Corynebacterium
glutamicum) 		5 / 12 ALA A 107
VAL A 108
GLY A  75
ALA A  81
ALA A 114
 None
 1.08A 5n5dA-5watA:
undetectable		 5n5dA-5watA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_E_CHDE401_0
(BILE SALT HYDROLASE)		 5wat HOMOSERINE KINASE
(Corynebacterium
glutamicum) 		4 / 8 ASN A 140
LEU A 171
LEU A 146
ALA A 143
 PO4  A 402 (-3.7A)
None
None
None
 0.78A 5y7pE-5watA:
undetectable		 5y7pE-5watA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 5wat HOMOSERINE KINASE
(Corynebacterium
glutamicum) 		5 / 10 LEU A  22
VAL A 298
VAL A 150
GLY A 148
LEU A 273
 None
 1.49A 6bsiA-5watA:
undetectable		 6bsiA-5watA:
25.56