SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5way'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5way TRANSCRIPTIONAL
ACTIVATOR
(Streptococcus
pneumoniae) 		4 / 8 SER A 244
GLY A 237
ALA A 242
ILE A 238
 None
 0.81A 1c9sI-5wayA:
undetectable
1c9sJ-5wayA:
undetectable		 1c9sI-5wayA:
9.85
1c9sJ-5wayA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5way TRANSCRIPTIONAL
ACTIVATOR
(Streptococcus
pneumoniae) 		4 / 8 GLY A 237
ALA A 242
ILE A 238
SER A 244
 None
 0.82A 1c9sU-5wayA:
undetectable
1c9sV-5wayA:
undetectable		 1c9sU-5wayA:
9.85
1c9sV-5wayA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4007_1
(SERUM ALBUMIN)		 5way TRANSCRIPTIONAL
ACTIVATOR
(Streptococcus
pneumoniae) 		4 / 8 LEU A 200
HIS A 197
LEU A 177
LEU A 181
 None
 0.90A 1e7cA-5wayA:
undetectable		 1e7cA-5wayA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5way TRANSCRIPTIONAL
ACTIVATOR
(Streptococcus
pneumoniae) 		4 / 7 GLY A 237
ALA A 242
ILE A 238
SER A 244
 None
 0.79A 1gtnA-5wayA:
undetectable
1gtnK-5wayA:
undetectable		 1gtnA-5wayA:
9.85
1gtnK-5wayA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5way TRANSCRIPTIONAL
ACTIVATOR
(Streptococcus
pneumoniae) 		4 / 8 SER A 244
GLY A 237
ALA A 242
ILE A 238
 None
 0.83A 1gtnE-5wayA:
undetectable
1gtnF-5wayA:
undetectable		 1gtnE-5wayA:
9.85
1gtnF-5wayA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_I_TRPI81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5way TRANSCRIPTIONAL
ACTIVATOR
(Streptococcus
pneumoniae) 		4 / 8 GLY A 237
ALA A 242
ILE A 238
SER A 244
 None
 0.82A 1utdI-5wayA:
undetectable
1utdJ-5wayA:
undetectable		 1utdI-5wayA:
9.85
1utdJ-5wayA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KUH_A_HLTA150_1
(CALMODULIN)		 5way TRANSCRIPTIONAL
ACTIVATOR
(Streptococcus
pneumoniae) 		4 / 6 LEU A 232
LEU A 253
MET A 233
GLU A 255
 None
 1.22A 2kuhA-5wayA:
2.4		 2kuhA-5wayA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 5way TRANSCRIPTIONAL
ACTIVATOR
(Streptococcus
pneumoniae) 		4 / 6 SER A 295
ASP A 299
LYS A 282
GLU A 288
 None
 1.28A 2vn1B-5wayA:
undetectable		 2vn1B-5wayA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_0
(PCZA361.24)		 5way TRANSCRIPTIONAL
ACTIVATOR
(Streptococcus
pneumoniae) 		5 / 12 GLU A 182
LEU A 181
LEU A 177
SER A 174
GLY A 240
 None
 0.98A 3g2oA-5wayA:
undetectable		 3g2oA-5wayA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_2
(NEURAMINIDASE)		 5way TRANSCRIPTIONAL
ACTIVATOR
(Streptococcus
pneumoniae) 		3 / 3 ARG A  66
TRP A  25
ILE A  68
 None
 1.03A 4mwxA-5wayA:
undetectable		 4mwxA-5wayA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_A_SAMA301_0
(PUTATIVE RNA
METHYLASE)		 5way TRANSCRIPTIONAL
ACTIVATOR
(Streptococcus
pneumoniae) 		5 / 12 THR A 322
HIS A 380
ASN A 321
LEU A 294
THR A 384
 None
 1.34A 4pooA-5wayA:
undetectable		 4pooA-5wayA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_A_MMSA511_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 5way TRANSCRIPTIONAL
ACTIVATOR
(Streptococcus
pneumoniae) 		4 / 7 HIS A 320
ASN A 321
HIS A 324
LEU A 325
 None
 0.80A 5m8rA-5wayA:
undetectable		 5m8rA-5wayA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_B_MMSB514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 5way TRANSCRIPTIONAL
ACTIVATOR
(Streptococcus
pneumoniae) 		4 / 8 HIS A 320
ASN A 321
HIS A 324
LEU A 325
 None
 0.80A 5m8rB-5wayA:
undetectable		 5m8rB-5wayA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_D_MMSD509_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 5way TRANSCRIPTIONAL
ACTIVATOR
(Streptococcus
pneumoniae) 		4 / 8 HIS A 320
ASN A 321
HIS A 324
LEU A 325
 None
 0.80A 5m8rD-5wayA:
undetectable		 5m8rD-5wayA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_0
(CYTOCHROME P450 1A1)		 5way TRANSCRIPTIONAL
ACTIVATOR
(Streptococcus
pneumoniae) 		5 / 12 ILE A 143
SER A 137
PHE A 213
GLY A 100
ILE A 121
 None
 1.03A 6dwnC-5wayA:
2.0		 6dwnC-5wayA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_D_AQ4D602_0
(CYTOCHROME P450 1A1)		 5way TRANSCRIPTIONAL
ACTIVATOR
(Streptococcus
pneumoniae) 		5 / 12 ILE A 143
SER A 137
PHE A 213
GLY A 100
ILE A 121
 None
 1.05A 6dwnD-5wayA:
undetectable		 6dwnD-5wayA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_1
(TUBULIN BETA CHAIN)		 5way TRANSCRIPTIONAL
ACTIVATOR
(Streptococcus
pneumoniae) 		5 / 12 HIS A  48
ALA A  52
PHE A  53
LEU A  16
ARG A  11
 None
 1.12A 6ew0G-5wayA:
undetectable		 6ew0G-5wayA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_1
(TUBULIN BETA CHAIN)		 5way TRANSCRIPTIONAL
ACTIVATOR
(Streptococcus
pneumoniae) 		5 / 12 LEU A  15
ALA A  52
PHE A  53
LEU A  16
ARG A  11
 None
 1.09A 6ew0G-5wayA:
undetectable		 6ew0G-5wayA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_B_LLLB301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5way TRANSCRIPTIONAL
ACTIVATOR
(Streptococcus
pneumoniae) 		4 / 7 ASP A 149
TYR A 326
GLU A 333
GLU A 160
 None
 1.21A 6mn5B-5wayA:
undetectable		 6mn5B-5wayA:
9.21