SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wb0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5wb0 FUSION GLYCOPROTEIN
F0
(Human
metapneumovirus) 		4 / 5 GLY F 393
ILE F 399
VAL F 424
SER F 391
 None
 1.20A 1rs7A-5wb0F:
undetectable		 1rs7A-5wb0F:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_1
(ANDROGEN RECEPTOR)		 5wb0 FUSION GLYCOPROTEIN
F0
(Human
metapneumovirus) 		5 / 12 LEU F 221
GLY F 257
VAL F 251
THR F  45
ILE F 124
 None
 1.40A 1z95A-5wb0F:
undetectable		 1z95A-5wb0F:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		 5wb0 FUSION GLYCOPROTEIN
F0
(Human
metapneumovirus) 		4 / 7 ILE F 217
TYR F 269
PHE F  48
GLU F 226
 None
 1.10A 2qebA-5wb0F:
undetectable		 2qebA-5wb0F:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_NCAA493_0
(CHORISMATE SYNTHASE)		 5wb0 FUSION GLYCOPROTEIN
F0
(Human
metapneumovirus) 		5 / 11 ALA F  86
MET F 270
ARG F 129
ALA F 125
VAL F 118
 None
 1.16A 2qhfA-5wb0F:
undetectable		 2qhfA-5wb0F:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDY_A_RBFA187_1
(LUMAZINE PROTEIN)		 5wb0 FUSION GLYCOPROTEIN
F0
(Human
metapneumovirus) 		5 / 12 VAL F 424
THR F 419
ILE F 410
ALA F 415
ASN F 395
 None
 1.22A 3ddyA-5wb0F:
undetectable		 3ddyA-5wb0F:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_A_VORA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 5wb0 FUSION GLYCOPROTEIN
F0
(Human
metapneumovirus) 		5 / 9 LEU F 375
SER F 428
ILE F 410
ALA F 415
THR F 419
 None
 1.08A 3mdtA-5wb0F:
undetectable		 3mdtA-5wb0F:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5wb0 FUSION GLYCOPROTEIN
F0
(Human
metapneumovirus) 		4 / 5 GLY F 393
ILE F 399
VAL F 424
SER F 391
 None
 1.26A 4d33B-5wb0F:
undetectable		 4d33B-5wb0F:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA208_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 5wb0 FUSION GLYCOPROTEIN
F0
(Human
metapneumovirus) 		4 / 4 ALA F 113
ALA F 116
ALA F 117
ALA F 120
 None
 0.13A 4oaeA-5wb0F:
0.6		 4oaeA-5wb0F:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 5wb0 FUSION GLYCOPROTEIN
F0
(Human
metapneumovirus) 		4 / 7 ALA F 161
THR F 160
ALA F 159
THR F 144
 None
 1.04A 4qw0K-5wb0F:
undetectable		 4qw0K-5wb0F:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 5wb0 FUSION GLYCOPROTEIN
F0
(Human
metapneumovirus) 		4 / 7 ALA F 161
THR F 160
ALA F 159
THR F 144
 None
 1.03A 4qw0Y-5wb0F:
undetectable		 4qw0Y-5wb0F:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X61_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 5wb0 FUSION GLYCOPROTEIN
F0
(Human
metapneumovirus) 		5 / 12 GLY F 257
GLY F 255
PRO F 274
LEU F 273
LEU F 221
 None
 1.29A 4x61A-5wb0F:
undetectable		 4x61A-5wb0F:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 5wb0 FUSION GLYCOPROTEIN
F0
(Human
metapneumovirus) 		4 / 7 ALA F 338
GLY F 121
THR F 127
ARG F  40
 None
 1.02A 5bs8A-5wb0F:
undetectable
5bs8B-5wb0F:
undetectable
5bs8C-5wb0F:
undetectable		 5bs8A-5wb0F:
12.13
5bs8B-5wb0F:
15.69
5bs8C-5wb0F:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0I_B_ACTB303_0
(SWI5-DEPENDENT HO
EXPRESSION PROTEIN 2)		 5wb0 FUSION GLYCOPROTEIN
F0
(Human
metapneumovirus) 		4 / 5 VAL F  55
THR F  74
ASP F  72
LEU F  71
 None
 1.29A 5m0iB-5wb0F:
2.2		 5m0iB-5wb0F:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPY_A_ACTA408_0
(THIOREDOXIN
REDUCTASE)		 5wb0 FUSION GLYCOPROTEIN
F0
(Human
metapneumovirus) 		3 / 3 PRO F 441
SER F 443
SER F 444
 None
 0.65A 6bpyA-5wb0F:
undetectable		 6bpyA-5wb0F:
undetectable