SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wb1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_A_FUAA702_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5wb1 ENVELOPE PROTEIN
US28, NANOBODY 7
FUSION PROTEIN
(Human
betaherpesvirus
5;
Lama
glama) 		5 / 12 PHE A 197
PHE A 116
LEU A 119
PHE A 237
ALA A 280
 None
 1.16A 1q23A-5wb1A:
undetectable
1q23B-5wb1A:
undetectable		 1q23A-5wb1A:
17.59
1q23B-5wb1A:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_D_FUAD705_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5wb1 ENVELOPE PROTEIN
US28, NANOBODY 7
FUSION PROTEIN
(Human
betaherpesvirus
5;
Lama
glama) 		5 / 12 PHE A 197
PHE A 116
LEU A 119
PHE A 237
ALA A 280
 None
 1.22A 1q23D-5wb1A:
undetectable
1q23E-5wb1A:
undetectable		 1q23D-5wb1A:
17.59
1q23E-5wb1A:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_H_FUAH709_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5wb1 ENVELOPE PROTEIN
US28, NANOBODY 7
FUSION PROTEIN
(Human
betaherpesvirus
5;
Lama
glama) 		5 / 12 PHE A 197
PHE A 116
LEU A 119
PHE A 237
ALA A 280
 None
 1.18A 1q23H-5wb1A:
undetectable
1q23I-5wb1A:
undetectable		 1q23H-5wb1A:
17.59
1q23I-5wb1A:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB8_0
(GRAMICIDIN A)		 5wb1 ENVELOPE PROTEIN
US28, NANOBODY 7
FUSION PROTEIN
(Lama
glama;
Human
betaherpesvirus
5) 		4 / 5 VAL A  42
GLY A  41
VAL A  43
TRP A  89
 None
 1.10A 1tkqB-5wb1A:
undetectable		 1tkqB-5wb1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KQE_A_ADNA1002_1
(APRATAXIN AND
PNK-LIKE FACTOR)		 5wb1 ENVELOPE PROTEIN
US28, NANOBODY 7
FUSION PROTEIN
(Human
betaherpesvirus
5;
Lama
glama) 		4 / 5 TYR A 206
SER A 205
TYR A 209
ARG A 210
 None
 0.90A 2kqeA-5wb1A:
undetectable		 2kqeA-5wb1A:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5wb1 ENVELOPE PROTEIN
US28, NANOBODY 7
FUSION PROTEIN
(Human
betaherpesvirus
5;
Lama
glama) 		4 / 7 ILE A 187
MET A 193
LEU A 248
LEU A 255
 None
 1.04A 2qqcB-5wb1A:
undetectable
2qqcC-5wb1A:
undetectable		 2qqcB-5wb1A:
14.29
2qqcC-5wb1A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		 5wb1 ENVELOPE PROTEIN
US28, NANOBODY 7
FUSION PROTEIN
(Human
betaherpesvirus
5;
Lama
glama) 		4 / 8 TYR A 131
SER A  67
VAL A 203
CYH A 207
 None
 1.07A 3b9lA-5wb1A:
1.3		 3b9lA-5wb1A:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_C_LEIC16_0
(COIL SER L16D-PEN)		 5wb1 ENVELOPE PROTEIN
US28, NANOBODY 7
FUSION PROTEIN
(Lama
glama;
Human
betaherpesvirus
5) 		4 / 6 LEU A 305
GLN A 300
LEU A 302
GLU A 301
 None
 1.09A 3h5gB-5wb1A:
undetectable
3h5gC-5wb1A:
undetectable		 3h5gB-5wb1A:
undetectable
3h5gC-5wb1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		 5wb1 ENVELOPE PROTEIN
US28, NANOBODY 7
FUSION PROTEIN
(Human
betaherpesvirus
5;
Lama
glama) 		5 / 12 THR A 252
LEU A 273
LEU A 269
LEU A 248
MET A 193
 None
 1.15A 3hm1A-5wb1A:
undetectable		 3hm1A-5wb1A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5wb1 ENVELOPE PROTEIN
US28, NANOBODY 7
FUSION PROTEIN
(Lama
glama;
Human
betaherpesvirus
5) 		3 / 3 TYR A 138
ASP A 128
ASP A  69
 None
 0.81A 3ou7B-5wb1A:
undetectable		 3ou7B-5wb1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXT_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 5wb1 ENVELOPE PROTEIN
US28, NANOBODY 7
FUSION PROTEIN
(Human
betaherpesvirus
5;
Lama
glama) 		5 / 12 VAL A1002
ALA A1024
MET A1034
VAL A1078
ALA A1097
 None
 0.96A 3qxtA-5wb1A:
18.3		 3qxtA-5wb1A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXT_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 5wb1 ENVELOPE PROTEIN
US28, NANOBODY 7
FUSION PROTEIN
(Human
betaherpesvirus
5;
Lama
glama) 		7 / 12 VAL A1002
LEU A1004
ALA A1024
MET A1034
VAL A1078
ALA A1097
TYR A1107
 None
 0.94A 3qxtB-5wb1A:
18.4		 3qxtB-5wb1A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5wb1 ENVELOPE PROTEIN
US28, NANOBODY 7
FUSION PROTEIN
(Human
betaherpesvirus
5;
Lama
glama) 		7 / 12 VAL A1002
ALA A1024
MET A1034
ASN A1073
VAL A1078
ALA A1097
TYR A1107
 None
 0.97A 3qxvA-5wb1A:
18.0		 3qxvA-5wb1A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5wb1 ENVELOPE PROTEIN
US28, NANOBODY 7
FUSION PROTEIN
(Human
betaherpesvirus
5;
Lama
glama) 		6 / 12 VAL A1002
ALA A1024
MET A1034
VAL A1078
ALA A1097
TYR A1107
 None
 1.00A 3qxvB-5wb1A:
17.9		 3qxvB-5wb1A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_C_MTXC2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5wb1 ENVELOPE PROTEIN
US28, NANOBODY 7
FUSION PROTEIN
(Human
betaherpesvirus
5;
Lama
glama) 		6 / 11 VAL A1002
ALA A1024
MET A1034
ASN A1073
VAL A1078
ALA A1097
 None
 0.94A 3qxvC-5wb1A:
18.3		 3qxvC-5wb1A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_D_MTXD2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5wb1 ENVELOPE PROTEIN
US28, NANOBODY 7
FUSION PROTEIN
(Human
betaherpesvirus
5;
Lama
glama) 		6 / 12 VAL A1002
ALA A1024
MET A1034
VAL A1078
ALA A1097
TYR A1107
 None
 0.93A 3qxvD-5wb1A:
18.1		 3qxvD-5wb1A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_E_MTXE2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5wb1 ENVELOPE PROTEIN
US28, NANOBODY 7
FUSION PROTEIN
(Human
betaherpesvirus
5;
Lama
glama) 		5 / 12 ALA A1024
MET A1034
VAL A1078
ALA A1097
TYR A1107
 None
 0.97A 3qxvE-5wb1A:
15.0		 3qxvE-5wb1A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_A_ADNA401_1
(APH(2'')-ID)		 5wb1 ENVELOPE PROTEIN
US28, NANOBODY 7
FUSION PROTEIN
(Human
betaherpesvirus
5;
Lama
glama) 		5 / 10 ALA A 132
ILE A 133
ILE A 226
LEU A 230
ILE A1101
 None
 1.31A 4dtaA-5wb1A:
undetectable		 4dtaA-5wb1A:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7G_B_ACTB902_0
(3-HYDROXYPROLINE
DEHYDRATSE)		 5wb1 ENVELOPE PROTEIN
US28, NANOBODY 7
FUSION PROTEIN
(Lama
glama;
Human
betaherpesvirus
5) 		4 / 7 ASP A1106
PRO A 997
SER A 220
HIS A 222
 None
 1.22A 4k7gB-5wb1A:
undetectable		 4k7gB-5wb1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_B_MRVB1101_1
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 5wb1 ENVELOPE PROTEIN
US28, NANOBODY 7
FUSION PROTEIN
(Human
betaherpesvirus
5;
Lama
glama) 		5 / 12 TYR A  40
TRP A  89
TYR A 244
THR A 252
GLU A 277
 None
 1.03A 4mbsB-5wb1A:
28.7		 4mbsB-5wb1A:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5wb1 ENVELOPE PROTEIN
US28, NANOBODY 7
FUSION PROTEIN
(Human
betaherpesvirus
5;
Lama
glama) 		4 / 5 ILE A 204
VAL A 203
CYH A 120
HIS A 283
 None
 1.33A 4rzvA-5wb1A:
0.7		 4rzvA-5wb1A:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5wb1 ENVELOPE PROTEIN
US28, NANOBODY 7
FUSION PROTEIN
(Lama
glama;
Human
betaherpesvirus
5) 		4 / 7 ARG A 129
PHE A 237
TYR A 208
TYR A 291
 None
 1.23A 5a06C-5wb1A:
undetectable		 5a06C-5wb1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5wb1 ENVELOPE PROTEIN
US28, NANOBODY 7
FUSION PROTEIN
(Lama
glama;
Human
betaherpesvirus
5) 		4 / 7 ARG A 129
PHE A 237
TYR A 208
TYR A 291
 None
 1.20A 5a06F-5wb1A:
undetectable		 5a06F-5wb1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5wb1 ENVELOPE PROTEIN
US28, NANOBODY 7
FUSION PROTEIN
(Lama
glama;
Human
betaherpesvirus
5) 		5 / 12 CYH A 120
SER A 118
ILE A 158
LEU A  75
TYR A 291
 None
 1.35A 5ycpA-5wb1A:
undetectable		 5ycpA-5wb1A:
18.89