SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wb5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 5wb5 PUTATIVE EUKARYOTIC
TRANSLATION
INITIATION FACTOR
EIF-4E
UNCHARACTERIZED
PROTEIN
(Leishmania
major) 		5 / 12 LEU B  14
ALA B  17
ALA B  20
VAL A  50
ARG A  58
 None
 1.27A 1cbrA-5wb5B:
undetectable		 1cbrA-5wb5B:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_B_REAB200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 5wb5 PUTATIVE EUKARYOTIC
TRANSLATION
INITIATION FACTOR
EIF-4E
UNCHARACTERIZED
PROTEIN
(Leishmania
major) 		5 / 12 LEU B  14
ALA B  17
ALA B  20
VAL A  50
ARG A  58
 None
 1.27A 1cbrB-5wb5B:
undetectable		 1cbrB-5wb5B:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMI_A_BHSA1610_1
(NITRIC OXIDE
SYNTHASE)		 5wb5 PUTATIVE EUKARYOTIC
TRANSLATION
INITIATION FACTOR
EIF-4E
(Leishmania
major) 		4 / 8 SER A  49
VAL A  47
PHE A  54
GLU A  52
 None
 1.05A 1dmiA-5wb5A:
undetectable
1dmiB-5wb5A:
undetectable		 1dmiA-5wb5A:
11.76
1dmiB-5wb5A:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)		 5wb5 PUTATIVE EUKARYOTIC
TRANSLATION
INITIATION FACTOR
EIF-4E
(Leishmania
major) 		5 / 12 ALA A 192
VAL A  96
LEU A 173
ALA A 174
LEU A 145
 None
 1.19A 1jipA-5wb5A:
undetectable		 1jipA-5wb5A:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_B_017B203_1
(HIV-1 PROTEASE)		 5wb5 PUTATIVE EUKARYOTIC
TRANSLATION
INITIATION FACTOR
EIF-4E
(Leishmania
major) 		4 / 7 GLU A  77
PRO A  86
MET A  82
LYS A  80
 None
 1.23A 2hs1B-5wb5A:
undetectable		 2hs1B-5wb5A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5wb5 PUTATIVE EUKARYOTIC
TRANSLATION
INITIATION FACTOR
EIF-4E
(Leishmania
major) 		4 / 7 PHE A  54
GLU A  52
SER A  49
VAL A  47
 None
 1.01A 3dqtA-5wb5A:
undetectable
3dqtB-5wb5A:
undetectable		 3dqtA-5wb5A:
12.14
3dqtB-5wb5A:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5J_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5wb5 PUTATIVE EUKARYOTIC
TRANSLATION
INITIATION FACTOR
EIF-4E
(Leishmania
major) 		4 / 7 PHE A  54
GLU A  52
SER A  49
VAL A  47
 None
 0.95A 4k5jA-5wb5A:
undetectable
4k5jB-5wb5A:
undetectable		 4k5jA-5wb5A:
12.06
4k5jB-5wb5A:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5wb5 PUTATIVE EUKARYOTIC
TRANSLATION
INITIATION FACTOR
EIF-4E
(Leishmania
major) 		3 / 3 ASP A  27
LYS A 166
LEU A  63
 None
 1.02A 4ptjA-5wb5A:
undetectable		 4ptjA-5wb5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADL_B_H4BB600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 5wb5 PUTATIVE EUKARYOTIC
TRANSLATION
INITIATION FACTOR
EIF-4E
(Leishmania
major) 		4 / 7 PHE A  54
GLU A  52
SER A  49
VAL A  47
 None
 1.02A 5adlA-5wb5A:
undetectable
5adlB-5wb5A:
undetectable		 5adlA-5wb5A:
12.06
5adlB-5wb5A:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ3_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5wb5 PUTATIVE EUKARYOTIC
TRANSLATION
INITIATION FACTOR
EIF-4E
(Leishmania
major) 		4 / 7 PHE A  54
GLU A  52
SER A  49
VAL A  47
 None
 1.03A 5fj3A-5wb5A:
undetectable
5fj3B-5wb5A:
undetectable		 5fj3A-5wb5A:
12.06
5fj3B-5wb5A:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV7_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5wb5 PUTATIVE EUKARYOTIC
TRANSLATION
INITIATION FACTOR
EIF-4E
(Leishmania
major) 		4 / 7 PHE A  54
GLU A  52
SER A  49
VAL A  47
 None
 0.99A 5vv7A-5wb5A:
undetectable
5vv7B-5wb5A:
undetectable		 5vv7A-5wb5A:
12.06
5vv7B-5wb5A:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVN_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5wb5 PUTATIVE EUKARYOTIC
TRANSLATION
INITIATION FACTOR
EIF-4E
(Leishmania
major) 		4 / 7 PHE A  54
GLU A  52
SER A  49
VAL A  47
 None
 1.02A 5vvnA-5wb5A:
undetectable
5vvnB-5wb5A:
undetectable		 5vvnA-5wb5A:
12.06
5vvnB-5wb5A:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_B_H4BB501_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5wb5 PUTATIVE EUKARYOTIC
TRANSLATION
INITIATION FACTOR
EIF-4E
(Leishmania
major) 		4 / 7 SER A  49
VAL A  47
PHE A  54
GLU A  52
 None
 1.01A 6av6A-5wb5A:
undetectable
6av6B-5wb5A:
undetectable		 6av6A-5wb5A:
23.26
6av6B-5wb5A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5wb5 PUTATIVE EUKARYOTIC
TRANSLATION
INITIATION FACTOR
EIF-4E
(Leishmania
major) 		4 / 7 PHE A  54
GLU A  52
SER A  49
VAL A  47
 None
 0.98A 6av6C-5wb5A:
0.4
6av6D-5wb5A:
undetectable		 6av6C-5wb5A:
23.26
6av6D-5wb5A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5wb5 PUTATIVE EUKARYOTIC
TRANSLATION
INITIATION FACTOR
EIF-4E
(Leishmania
major) 		4 / 7 SER A  49
VAL A  47
PHE A  54
GLU A  52
 None
 0.99A 6av7A-5wb5A:
undetectable
6av7B-5wb5A:
undetectable		 6av7A-5wb5A:
23.26
6av7B-5wb5A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GB9_A_ACTA508_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 5wb5 PUTATIVE EUKARYOTIC
TRANSLATION
INITIATION FACTOR
EIF-4E
(Leishmania
major) 		3 / 3 VAL A  79
ALA A  87
GLN A  76
 None
 0.66A 6gb9A-5wb5A:
undetectable		 6gb9A-5wb5A:
undetectable