SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wbf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_1
(ESTROGEN RECEPTOR)		 5wbf METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER (TLPC)
(Helicobacter
pylori) 		5 / 12 ALA A 117
LEU A 102
LEU A  94
LEU A  95
LEU A  70
 None
 1.02A 1errB-5wbfA:
undetectable		 1errB-5wbfA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXH_B_PACB1001_0
(PENICILLIN ACYLASE)		 5wbf METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER (TLPC)
(Helicobacter
pylori) 		4 / 7 MET A 135
SER A 104
ALA A 179
ILE A 106
 None
 1.05A 1fxhA-5wbfA:
undetectable
1fxhB-5wbfA:
undetectable		 1fxhA-5wbfA:
21.79
1fxhB-5wbfA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_A_EAAA224_1
(GLUTATHIONE
TRANSFERASE)		 5wbf METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER (TLPC)
(Helicobacter
pylori) 		5 / 12 TYR A 239
ARG A 209
GLY A 205
LEU A 211
PHE A 267
 None
 1.14A 1gseA-5wbfA:
undetectable		 1gseA-5wbfA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		 5wbf METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER (TLPC)
(Helicobacter
pylori) 		5 / 12 LEU A 180
LEU A 169
GLY A 178
MET A 135
ILE A 145
 None
 1.26A 1p93A-5wbfA:
undetectable		 1p93A-5wbfA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_1
(ESTROGEN RECEPTOR)		 5wbf METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER (TLPC)
(Helicobacter
pylori) 		5 / 12 ALA A 117
LEU A 102
LEU A  94
LEU A  95
LEU A  70
 None
 1.03A 2jfaA-5wbfA:
undetectable		 2jfaA-5wbfA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_1
(ESTROGEN RECEPTOR)		 5wbf METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER (TLPC)
(Helicobacter
pylori) 		6 / 12 ALA A 117
LEU A 102
LEU A  94
LEU A  95
GLY A  66
LEU A  70
 None
 1.09A 2jfaB-5wbfA:
undetectable		 2jfaB-5wbfA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_1
(ESTROGEN RECEPTOR)		 5wbf METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER (TLPC)
(Helicobacter
pylori) 		5 / 12 ALA A 117
LEU A 102
LEU A  94
LEU A  95
LEU A  70
 None
 0.96A 2qxsA-5wbfA:
undetectable		 2qxsA-5wbfA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_1
(ESTROGEN RECEPTOR)		 5wbf METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER (TLPC)
(Helicobacter
pylori) 		5 / 12 ALA A 117
LEU A 102
LEU A  94
LEU A  95
LEU A  70
 None
 1.03A 2qxsB-5wbfA:
undetectable		 2qxsB-5wbfA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5wbf METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER (TLPC)
(Helicobacter
pylori) 		4 / 5 LEU A 131
GLN A 138
THR A 136
THR A 116
 None
 1.23A 2zj0B-5wbfA:
undetectable		 2zj0B-5wbfA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI9_X_SAMX501_0
(UPF0217 PROTEIN
MJ1640)		 5wbf METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER (TLPC)
(Helicobacter
pylori) 		5 / 9 LEU A 142
ILE A 139
GLY A 178
GLU A  71
LEU A 167
 None
 1.12A 3ai9X-5wbfA:
undetectable		 3ai9X-5wbfA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_DIFB585_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5wbf METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER (TLPC)
(Helicobacter
pylori) 		5 / 12 VAL A 103
ILE A  63
GLY A  66
ALA A  67
LEU A  74
 None
 0.82A 3n8yB-5wbfA:
undetectable		 3n8yB-5wbfA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA214_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		 5wbf METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER (TLPC)
(Helicobacter
pylori) 		5 / 10 PHE A 268
PHE A 182
GLY A  66
PHE A  93
ASN A  97
 None
 0.91A 3r6wA-5wbfA:
undetectable
3r6wB-5wbfA:
undetectable		 3r6wA-5wbfA:
20.73
3r6wB-5wbfA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA602_1
(SERUM ALBUMIN)		 5wbf METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER (TLPC)
(Helicobacter
pylori) 		4 / 6 ARG A 113
ALA A 105
ASP A  83
LEU A 169
 None
 0.88A 4ot2A-5wbfA:
undetectable		 4ot2A-5wbfA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_1
(ESTROGEN RECEPTOR)		 5wbf METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER (TLPC)
(Helicobacter
pylori) 		6 / 12 ALA A 117
LEU A 102
LEU A  94
LEU A  95
GLY A  66
LEU A  70
 None
 1.11A 4xi3B-5wbfA:
undetectable		 4xi3B-5wbfA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_1
(ESTROGEN RECEPTOR)		 5wbf METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER (TLPC)
(Helicobacter
pylori) 		5 / 12 ALA A 117
LEU A 102
LEU A  94
GLY A  66
LEU A  70
 None
 1.05A 4xi3C-5wbfA:
undetectable		 4xi3C-5wbfA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_1
(ESTROGEN RECEPTOR)		 5wbf METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER (TLPC)
(Helicobacter
pylori) 		5 / 12 ALA A 117
LEU A 102
LEU A  94
LEU A  95
LEU A  70
 None
 0.99A 4xi3C-5wbfA:
undetectable		 4xi3C-5wbfA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_1
(ESTROGEN RECEPTOR)		 5wbf METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER (TLPC)
(Helicobacter
pylori) 		5 / 12 ALA A 117
LEU A 102
LEU A  94
LEU A  95
LEU A  70
 None
 0.96A 4xi3D-5wbfA:
undetectable		 4xi3D-5wbfA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 5wbf METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER (TLPC)
(Helicobacter
pylori) 		5 / 12 PHE A  93
LEU A 167
ALA A  67
ILE A  56
ILE A 165
 None
 1.20A 5hbsA-5wbfA:
undetectable		 5hbsA-5wbfA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LBT_A_6T0A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5wbf METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER (TLPC)
(Helicobacter
pylori) 		5 / 10 ILE A 186
PHE A 267
TRP A 278
GLY A 205
TYR A 239
 None
 1.39A 5lbtA-5wbfA:
undetectable
5lbtB-5wbfA:
undetectable		 5lbtA-5wbfA:
22.81
5lbtB-5wbfA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_B_OQRB302_0
(SULFOTRANSFERASE)		 5wbf METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER (TLPC)
(Helicobacter
pylori) 		5 / 10 MET A  60
ILE A  59
VAL A 100
LEU A 101
PHE A 189
 None
 1.11A 5tixB-5wbfA:
undetectable		 5tixB-5wbfA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DHB_A_BEZA202_0
(HEPATITIS A VIRUS
CELLULAR RECEPTOR 2)		 5wbf METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER (TLPC)
(Helicobacter
pylori) 		4 / 6 ARG A 113
ILE A  81
ASN A  82
ASP A  83
 None
 1.14A 6dhbA-5wbfA:
undetectable		 6dhbA-5wbfA:
16.92