SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wc1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD507_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5wc1 MEIOTIC SPINDLE
FORMATION PROTEIN
MEI-1
(Caenorhabditis
elegans) 		4 / 7 PHE A 290
ALA A 338
ILE A 242
ILE A 357
 None
 0.73A 1oniD-5wc1A:
undetectable
1oniF-5wc1A:
undetectable		 1oniD-5wc1A:
15.60
1oniF-5wc1A:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_B_PODB700_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 5wc1 MEIOTIC SPINDLE
FORMATION PROTEIN
MEI-1
(Caenorhabditis
elegans) 		5 / 12 LEU A 318
LEU A 349
ALA A 337
VAL A 335
ALA A 228
 None
 1.02A 1sa1A-5wc1A:
undetectable
1sa1B-5wc1A:
undetectable		 1sa1A-5wc1A:
21.51
1sa1B-5wc1A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_D_TC9D1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5wc1 MEIOTIC SPINDLE
FORMATION PROTEIN
MEI-1
(Caenorhabditis
elegans) 		4 / 8 TYR A 386
ARG A 367
ILE A 371
ASP A 387
 None
 1.07A 2xytE-5wc1A:
undetectable		 2xytE-5wc1A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_G_TC9G1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5wc1 MEIOTIC SPINDLE
FORMATION PROTEIN
MEI-1
(Caenorhabditis
elegans) 		4 / 8 TYR A 386
ARG A 367
ILE A 371
ASP A 387
 None
 1.05A 2xytH-5wc1A:
undetectable		 2xytH-5wc1A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_2
(TUBULIN BETA CHAIN)		 5wc1 MEIOTIC SPINDLE
FORMATION PROTEIN
MEI-1
(Caenorhabditis
elegans) 		6 / 12 LEU A 318
THR A 339
ALA A 337
VAL A 335
ALA A 228
ILE A 291
 None
 1.14A 4x1kD-5wc1A:
undetectable		 4x1kD-5wc1A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_D_LOCD502_2
(TUBULIN BETA CHAIN)		 5wc1 MEIOTIC SPINDLE
FORMATION PROTEIN
MEI-1
(Caenorhabditis
elegans) 		5 / 12 LEU A 318
LEU A 349
THR A 339
VAL A 335
ALA A 228
 None
 0.96A 4x1yD-5wc1A:
undetectable		 4x1yD-5wc1A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_D_LOCD502_2
(TUBULIN BETA CHAIN)		 5wc1 MEIOTIC SPINDLE
FORMATION PROTEIN
MEI-1
(Caenorhabditis
elegans) 		6 / 12 LEU A 318
THR A 339
ALA A 337
VAL A 335
ALA A 228
ILE A 291
 None
 1.17A 4x1yD-5wc1A:
undetectable		 4x1yD-5wc1A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PHH_A_LDPA414_1
(LYSINE-SPECIFIC
DEMETHYLASE 4D)		 5wc1 MEIOTIC SPINDLE
FORMATION PROTEIN
MEI-1
(Caenorhabditis
elegans) 		4 / 6 GLU A 436
ALA A 435
LEU A 433
TYR A 416
 None
 0.92A 5phhA-5wc1A:
undetectable		 5phhA-5wc1A:
20.95