SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wc2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_1
(HEMK PROTEIN)		 5wc2 PACHYTENE CHECKPOINT
PROTEIN 2 HOMOLOG
(Homo
sapiens) 		3 / 3 ASP A 285
PHE A 233
ASN A 278
 None
 0.81A 1sg9B-5wc2A:
undetectable		 1sg9B-5wc2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_2
(POL PROTEIN)		 5wc2 PACHYTENE CHECKPOINT
PROTEIN 2 HOMOLOG
(Homo
sapiens) 		4 / 7 ASP A 252
ALA A 253
GLY A 179
ILE A 319
 ADP  A 501 ( 4.7A)
None
None
None
 0.89A 2fxdB-5wc2A:
undetectable		 2fxdB-5wc2A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_1
(ANDROGEN RECEPTOR)		 5wc2 PACHYTENE CHECKPOINT
PROTEIN 2 HOMOLOG
(Homo
sapiens) 		5 / 12 LEU A 373
ASN A 374
LEU A 372
VAL A 418
ALA A 324
 None
 1.15A 2oz7A-5wc2A:
undetectable		 2oz7A-5wc2A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5wc2 PACHYTENE CHECKPOINT
PROTEIN 2 HOMOLOG
(Homo
sapiens) 		5 / 12 ILE A 284
ALA A 122
VAL A 249
ILE A 240
PHE A 233
 None
 1.09A 3b2rA-5wc2A:
undetectable		 3b2rA-5wc2A:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5wc2 PACHYTENE CHECKPOINT
PROTEIN 2 HOMOLOG
(Homo
sapiens) 		5 / 11 ILE A 284
ALA A 122
VAL A 249
ILE A 240
PHE A 233
 None
 1.08A 3b2rB-5wc2A:
undetectable		 3b2rB-5wc2A:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 5wc2 PACHYTENE CHECKPOINT
PROTEIN 2 HOMOLOG
(Homo
sapiens) 		5 / 12 ASP A 285
LEU A 281
THR A 297
ILE A 251
LEU A 257
 None
 1.12A 3k2hA-5wc2A:
undetectable		 3k2hA-5wc2A:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 5wc2 PACHYTENE CHECKPOINT
PROTEIN 2 HOMOLOG
(Homo
sapiens) 		5 / 12 VAL A 307
ILE A 284
VAL A 249
ILE A 210
LEU A 257
 None
 1.28A 4a84A-5wc2A:
undetectable		 4a84A-5wc2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EVR_A_BEZA401_0
(PUTATIVE ABC
TRANSPORTER SUBUNIT,
SUBSTRATE-BINDING
COMPONENT)		 5wc2 PACHYTENE CHECKPOINT
PROTEIN 2 HOMOLOG
(Homo
sapiens) 		5 / 11 LEU A  66
VAL A  70
SER A  31
ALA A  33
SER A  41
 None
 1.39A 4evrA-5wc2A:
undetectable		 4evrA-5wc2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB201_0
(HYDROXYNITRILE LYASE)		 5wc2 PACHYTENE CHECKPOINT
PROTEIN 2 HOMOLOG
(Homo
sapiens) 		5 / 11 VAL A  23
VAL A  95
VAL A  21
ILE A  51
TRP A  58
 None
 1.07A 5e4dB-5wc2A:
undetectable		 5e4dB-5wc2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB201_0
(HYDROXYNITRILE LYASE)		 5wc2 PACHYTENE CHECKPOINT
PROTEIN 2 HOMOLOG
(Homo
sapiens) 		5 / 11 VAL A  23
VAL A  95
VAL A  21
TRP A  58
LEU A  46
 None
 1.00A 5e4dB-5wc2A:
undetectable		 5e4dB-5wc2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 5wc2 PACHYTENE CHECKPOINT
PROTEIN 2 HOMOLOG
(Homo
sapiens) 		4 / 7 LEU A 296
VAL A 174
ILE A 240
LYS A 288
 None
 1.09A 5jh7C-5wc2A:
undetectable		 5jh7C-5wc2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA608_0
(ACETYLCHOLINESTERASE)		 5wc2 PACHYTENE CHECKPOINT
PROTEIN 2 HOMOLOG
(Homo
sapiens) 		4 / 7 ASP A 285
THR A 282
LEU A 281
VAL A 310
 None
 1.12A 5ov9A-5wc2A:
undetectable		 5ov9A-5wc2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5wc2 PACHYTENE CHECKPOINT
PROTEIN 2 HOMOLOG
(Homo
sapiens) 		4 / 5 LYS A 190
ALA A 193
LEU A 196
LEU A 209
 None
 0.84A 5vkqA-5wc2A:
undetectable
5vkqD-5wc2A:
undetectable		 5vkqA-5wc2A:
undetectable
5vkqD-5wc2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5wc2 PACHYTENE CHECKPOINT
PROTEIN 2 HOMOLOG
(Homo
sapiens) 		4 / 5 LEU A 209
LYS A 190
ALA A 193
LEU A 196
 None
 0.82A 5vkqA-5wc2A:
undetectable
5vkqB-5wc2A:
undetectable		 5vkqA-5wc2A:
undetectable
5vkqB-5wc2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5wc2 PACHYTENE CHECKPOINT
PROTEIN 2 HOMOLOG
(Homo
sapiens) 		4 / 5 LEU A 209
LYS A 190
ALA A 193
LEU A 196
 None
 0.80A 5vkqB-5wc2A:
undetectable
5vkqC-5wc2A:
undetectable		 5vkqB-5wc2A:
undetectable
5vkqC-5wc2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5wc2 PACHYTENE CHECKPOINT
PROTEIN 2 HOMOLOG
(Homo
sapiens) 		4 / 5 LEU A 209
LYS A 190
ALA A 193
LEU A 196
 None
 0.85A 5vkqC-5wc2A:
undetectable
5vkqD-5wc2A:
undetectable		 5vkqC-5wc2A:
undetectable
5vkqD-5wc2A:
undetectable