SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wc8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXF_C_MTXC3278_1
(PTERIDINE REDUCTASE
2)		 5wc8 SIAD
(Mannheimia
haemolytica) 		5 / 11 SER M 356
TYR M 358
TYR M 383
LEU M 366
TYR M 371
 None
 1.48A 1mxfC-5wc8M:
5.2		 1mxfC-5wc8M:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_A_DESA129_1
(TRANSTHYRETIN)		 5wc8 SIAD
(Mannheimia
haemolytica) 		4 / 4 LYS M 114
LEU M 110
LEU M 136
SER M 135
 BR  M 501 (-3.6A)
None
None
None
 1.13A 1tt6A-5wc8M:
undetectable		 1tt6A-5wc8M:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_B_DESB128_1
(TRANSTHYRETIN)		 5wc8 SIAD
(Mannheimia
haemolytica) 		4 / 5 LYS M 114
LEU M 110
LEU M 136
SER M 135
 BR  M 501 (-3.6A)
None
None
None
 1.09A 1tt6B-5wc8M:
undetectable		 1tt6B-5wc8M:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)		 5wc8 SIAD
(Mannheimia
haemolytica) 		3 / 3 PHE M 255
TYR M 267
TYR M 260
 None
 0.83A 1x70B-5wc8M:
undetectable		 1x70B-5wc8M:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 5wc8 SIAD
(Mannheimia
haemolytica) 		4 / 5 ILE M 288
ILE M 379
ILE M 268
LEU M 342
 None
 0.90A 1zgyA-5wc8M:
undetectable		 1zgyA-5wc8M:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOX_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 5wc8 SIAD
(Mannheimia
haemolytica) 		4 / 8 PHE M 255
GLN M 258
TYR M 260
TYR M 267
 None
 1.45A 2aoxA-5wc8M:
undetectable		 2aoxA-5wc8M:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5wc8 SIAD
(Mannheimia
haemolytica) 		5 / 9 LEU M  36
LEU M 125
ILE M 127
LEU M  65
ILE M  63
 None
 1.13A 2f7aB-5wc8M:
undetectable		 2f7aB-5wc8M:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q8H_A_TF4A438_1
([PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1)		 5wc8 SIAD
(Mannheimia
haemolytica) 		4 / 6 LEU M 335
ILE M 401
ARG M 332
ILE M 253
 None
None
BR  M 509 (-3.3A)
None
 0.85A 2q8hA-5wc8M:
undetectable		 2q8hA-5wc8M:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		 5wc8 SIAD
(Mannheimia
haemolytica) 		4 / 7 ILE M 369
PHE M 376
ILE M 379
PHE M 361
 None
 1.10A 2qb4A-5wc8M:
undetectable		 2qb4A-5wc8M:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_ACTA1181_0
(WNT INHIBITORY
FACTOR 1)		 5wc8 SIAD
(Mannheimia
haemolytica) 		3 / 3 TYR M 158
VAL M 209
THR M 155
 None
 0.89A 2ygnA-5wc8M:
undetectable		 2ygnA-5wc8M:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_B_DSFB319_1
(GLR4197 PROTEIN)		 5wc8 SIAD
(Mannheimia
haemolytica) 		5 / 9 ILE M 254
VAL M 334
THR M 345
ILE M 348
ILE M 352
 None
 1.17A 3p4wB-5wc8M:
undetectable		 3p4wB-5wc8M:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_D_DSFD319_1
(GLR4197 PROTEIN)		 5wc8 SIAD
(Mannheimia
haemolytica) 		5 / 10 ILE M 254
VAL M 334
THR M 345
ILE M 348
ILE M 352
 None
 1.16A 3p4wD-5wc8M:
undetectable		 3p4wD-5wc8M:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5wc8 SIAD
(Mannheimia
haemolytica) 		4 / 6 GLU M 380
TYR M 371
LEU M 366
PHE M 376
 None
 1.30A 4twdF-5wc8M:
undetectable
4twdG-5wc8M:
undetectable		 4twdF-5wc8M:
21.90
4twdG-5wc8M:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1R_A_STRA600_1
(CYTOCHROME P450 3A4)		 5wc8 SIAD
(Mannheimia
haemolytica) 		4 / 5 ASP M 202
PHE M 204
PHE M 201
VAL M 148
 None
 1.17A 5a1rA-5wc8M:
undetectable		 5a1rA-5wc8M:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_A_ILEA601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5wc8 SIAD
(Mannheimia
haemolytica) 		4 / 6 THR M 340
VAL M 343
TYR M 344
HIS M 382
 None
 0.96A 5eckA-5wc8M:
undetectable		 5eckA-5wc8M:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_D_ILED601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5wc8 SIAD
(Mannheimia
haemolytica) 		4 / 6 THR M 340
VAL M 343
TYR M 344
HIS M 382
 None
 0.95A 5eckD-5wc8M:
2.2		 5eckD-5wc8M:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_A_ILEA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5wc8 SIAD
(Mannheimia
haemolytica) 		4 / 6 THR M 340
VAL M 343
TYR M 344
HIS M 382
 None
 0.98A 5eclA-5wc8M:
undetectable		 5eclA-5wc8M:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5wc8 SIAD
(Mannheimia
haemolytica) 		4 / 6 THR M 340
VAL M 343
TYR M 344
HIS M 382
 None
 0.83A 5ecoA-5wc8M:
1.6		 5ecoA-5wc8M:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 5wc8 SIAD
(Mannheimia
haemolytica) 		4 / 7 TYR M 278
ILE M 253
LEU M 312
GLY M 311
 None
 0.80A 5nooA-5wc8M:
undetectable		 5nooA-5wc8M:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 5wc8 SIAD
(Mannheimia
haemolytica) 		4 / 7 TYR M 278
ILE M 253
LEU M 312
GLY M 311
 None
 0.87A 5nooB-5wc8M:
undetectable		 5nooB-5wc8M:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 5wc8 SIAD
(Mannheimia
haemolytica) 		4 / 7 GLU M 124
TYR M 126
ALA M 141
GLY M 145
 None
 1.06A 5uxdA-5wc8M:
undetectable		 5uxdA-5wc8M:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5wc8 SIAD
(Mannheimia
haemolytica) 		4 / 9 TYR M 176
ILE M 103
ILE M 107
LEU M 110
 None
 0.78A 5vkqB-5wc8M:
undetectable
5vkqC-5wc8M:
undetectable		 5vkqB-5wc8M:
12.13
5vkqC-5wc8M:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEO_A_DHIA4_0
((DPR)PY(DHI)PKDL(DGN
))		 5wc8 SIAD
(Mannheimia
haemolytica) 		3 / 3 TYR M 106
PRO M  98
LEU M  94
 None
BR  M 503 ( 4.0A)
None
 0.76A 6beoA-5wc8M:
undetectable		 6beoA-5wc8M:
3.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA414_0
(AROMATIC
PEROXYGENASE)		 5wc8 SIAD
(Mannheimia
haemolytica) 		4 / 5 PHE M 361
VAL M 301
PRO M 263
VAL M 365
 None
 1.18A 6ekzA-5wc8M:
undetectable		 6ekzA-5wc8M:
10.11