SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wcd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 5wcd VRC315 04-1D02 FAB
HEAVY CHAIN
(Homo
sapiens) 		5 / 12 LEU H  78
ASP H  73
GLY H  30
ASP H  98
GLY H  99
 None
 1.14A 1zz1C-5wcdH:
undetectable		 1zz1C-5wcdH:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_A_5FWA601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5wcd VRC315 04-1D02 FAB
HEAVY CHAIN
(Homo
sapiens) 		5 / 12 VAL H 174
VAL H 193
SER H 191
ASN H 208
ASN H 166
 None
 1.43A 2y03A-5wcdH:
undetectable		 2y03A-5wcdH:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_B_5FWB601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5wcd VRC315 04-1D02 FAB
HEAVY CHAIN
(Homo
sapiens) 		5 / 12 VAL H 174
VAL H 193
SER H 191
ASN H 208
ASN H 166
 None
 1.47A 2y03B-5wcdH:
undetectable		 2y03B-5wcdH:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5wcd VRC315 04-1D02 FAB
HEAVY CHAIN
(Homo
sapiens) 		4 / 6 VAL H 122
ARG H  66
VAL H  18
PHE H  67
 None
 1.40A 3jx4A-5wcdH:
undetectable
3jx4B-5wcdH:
undetectable		 3jx4A-5wcdH:
21.43
3jx4B-5wcdH:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADD_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5wcd VRC315 04-1D02 FAB
HEAVY CHAIN
(Homo
sapiens) 		4 / 6 VAL H 122
ARG H  66
VAL H  18
PHE H  67
 None
 1.40A 5addA-5wcdH:
undetectable
5addB-5wcdH:
undetectable		 5addA-5wcdH:
21.43
5addB-5wcdH:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADE_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5wcd VRC315 04-1D02 FAB
HEAVY CHAIN
(Homo
sapiens) 		4 / 6 VAL H 122
ARG H  66
VAL H  18
PHE H  67
 None
 1.40A 5adeA-5wcdH:
undetectable
5adeB-5wcdH:
undetectable		 5adeA-5wcdH:
21.43
5adeB-5wcdH:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPY_A_ACTA408_0
(THIOREDOXIN
REDUCTASE)		 5wcd VRC315 04-1D02 FAB
HEAVY CHAIN
(Homo
sapiens) 		3 / 3 PRO H 196
SER H 198
SER H 199
 None
 0.48A 6bpyA-5wcdH:
undetectable		 6bpyA-5wcdH:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7M_B_68HB405_0
(BETA-1 ADRENERGIC
RECEPTOR)		 5wcd VRC315 04-1D02 FAB
HEAVY CHAIN
(Homo
sapiens) 		5 / 12 VAL H 174
VAL H 193
SER H 191
ASN H 208
ASN H 166
 None
 1.45A 6h7mB-5wcdH:
undetectable		 6h7mB-5wcdH:
17.82