SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wch'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_B_FOLB187_0
(DIHYDROFOLATE
REDUCTASE)
5wch PROBABLE UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE FAF-X

(Homo
sapiens)
5 / 12 ILE A1744
ALA A1948
PHE A1921
PHE A1816
GLN A1748
None
1.14A 1dhfB-5wchA:
undetectable
1dhfB-5wchA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHS_A_CLMA999_0
(PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE))
5wch PROBABLE UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE FAF-X

(Homo
sapiens)
6 / 12 SER A1692
ILE A1572
ILE A1585
PHE A1651
VAL A1694
LEU A1697
None
1.43A 1qhsA-5wchA:
undetectable
1qhsA-5wchA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA6_A_SCKA902_1
(ACETYLCHOLINESTERASE)
5wch PROBABLE UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE FAF-X

(Homo
sapiens)
5 / 10 GLU A1915
MET A1916
ASN A1918
LEU A1951
TYR A1953
None
1.39A 2ha6A-5wchA:
undetectable
2ha6A-5wchA:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA6_B_SCKB952_1
(ACETYLCHOLINESTERASE)
5wch PROBABLE UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE FAF-X

(Homo
sapiens)
5 / 10 GLU A1915
MET A1916
ASN A1918
LEU A1951
TYR A1953
None
1.41A 2ha6B-5wchA:
undetectable
2ha6B-5wchA:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_A_FOLA1188_0
(DIHYDROFOLATE
REDUCTASE)
5wch PROBABLE UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE FAF-X

(Homo
sapiens)
5 / 12 ILE A1744
ALA A1948
PHE A1921
PHE A1816
GLN A1748
None
1.10A 2w3mA-5wchA:
undetectable
2w3mA-5wchA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_B_FOLB1188_0
(DIHYDROFOLATE
REDUCTASE)
5wch PROBABLE UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE FAF-X

(Homo
sapiens)
5 / 12 ILE A1744
ALA A1948
PHE A1921
PHE A1816
GLN A1748
None
1.05A 2w3mB-5wchA:
undetectable
2w3mB-5wchA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)
5wch PROBABLE UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE FAF-X

(Homo
sapiens)
5 / 12 GLY A1867
VAL A1866
LEU A1822
MET A1824
ILE A1578
None
1.04A 3h52B-5wchA:
undetectable
3h52B-5wchA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_A_PFLA319_1
(GLR4197 PROTEIN)
5wch PROBABLE UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE FAF-X

(Homo
sapiens)
4 / 7 PRO A1826
LEU A1793
THR A1828
ILE A1786
None
0.99A 3p50A-5wchA:
undetectable
3p50A-5wchA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_B_PFLB319_1
(GLR4197 PROTEIN)
5wch PROBABLE UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE FAF-X

(Homo
sapiens)
4 / 7 PRO A1826
LEU A1793
THR A1828
ILE A1786
None
0.99A 3p50B-5wchA:
undetectable
3p50B-5wchA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)
5wch PROBABLE UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE FAF-X

(Homo
sapiens)
5 / 11 LEU A1647
PHE A1651
SER A1570
PHE A1952
VAL A1792
None
1.06A 4claA-5wchA:
undetectable
4claA-5wchA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
5wch PROBABLE UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE FAF-X

(Homo
sapiens)
4 / 8 GLY A1558
VAL A1557
GLN A1573
ILE A1572
None
0.87A 4fglD-5wchA:
undetectable
4fglD-5wchA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KEB_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)
5wch PROBABLE UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE FAF-X

(Homo
sapiens)
5 / 12 ILE A1744
ALA A1948
PHE A1921
PHE A1816
GLN A1748
None
1.11A 4kebB-5wchA:
undetectable
4kebB-5wchA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_A_FOLA301_1
(FOLATE RECEPTOR
ALPHA)
5wch PROBABLE UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE FAF-X

(Homo
sapiens)
3 / 3 ASP A1902
TRP A1945
SER A1570
None
1.04A 4lrhA-5wchA:
undetectable
4lrhA-5wchA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_F_MZMF302_1
(ALPHA-CARBONIC
ANHYDRASE)
5wch PROBABLE UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE FAF-X

(Homo
sapiens)
5 / 10 ASP A1695
ASN A1691
VAL A1694
LEU A1714
ALA A1794
None
1.43A 4yhaF-5wchA:
undetectable
4yhaF-5wchA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)
5wch PROBABLE UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE FAF-X

(Homo
sapiens)
4 / 7 ALA A1564
THR A1565
TYR A1567
VAL A1678
None
1.11A 5ecnA-5wchA:
undetectable
5ecnA-5wchA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_A_SALA301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)
5wch PROBABLE UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE FAF-X

(Homo
sapiens)
4 / 5 ALA A1794
VAL A1792
PHE A1690
ILE A1578
None
0.91A 5of1A-5wchA:
undetectable
5of1A-5wchA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_B_SALB301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)
5wch PROBABLE UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE FAF-X

(Homo
sapiens)
4 / 5 ALA A1794
VAL A1792
PHE A1690
ILE A1578
None
0.89A 5of1B-5wchA:
undetectable
5of1B-5wchA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XU8_A_DX4A701_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2)
5wch PROBABLE UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE FAF-X

(Homo
sapiens)
6 / 8 GLY A1558
LEU A1559
ASN A1569
SER A1570
GLN A1573
PHE A1900
None
0.72A 5xu8A-5wchA:
31.0
5xu8A-5wchA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GH9_A_MIXA1003_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)
5wch PROBABLE UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE FAF-X

(Homo
sapiens)
4 / 5 ASN A1561
GLY A1873
HIS A1879
ASP A1901
None
0.35A 6gh9A-5wchA:
27.5
6gh9A-5wchA:
32.10