SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wcj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		 5wcj METHYLTRANSFERASE-LI
KE PROTEIN 13
(Homo
sapiens) 		5 / 12 ALA A 479
PHE A 651
LEU A 507
LEU A 676
PHE A 515
 None
 1.11A 1dtlA-5wcjA:
undetectable		 1dtlA-5wcjA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 5wcj METHYLTRANSFERASE-LI
KE PROTEIN 13
(Homo
sapiens) 		5 / 12 MET A 573
VAL A 571
LEU A 497
ALA A 479
ILE A 478
 None
 1.02A 1epbA-5wcjA:
undetectable		 1epbA-5wcjA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 5wcj METHYLTRANSFERASE-LI
KE PROTEIN 13
(Homo
sapiens) 		5 / 11 GLY A 501
GLY A 503
GLU A 524
ASP A 551
GLY A 552
 SAH  A 705 (-3.5A)
SAH  A 705 (-3.6A)
SAH  A 705 (-2.7A)
SAH  A 705 (-3.4A)
SAH  A 705 (-3.8A)
 0.74A 1jg3A-5wcjA:
8.6		 1jg3A-5wcjA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_B_ADNB550_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 5wcj METHYLTRANSFERASE-LI
KE PROTEIN 13
(Homo
sapiens) 		5 / 11 GLY A 501
GLY A 503
GLU A 524
ASP A 551
GLY A 552
 SAH  A 705 (-3.5A)
SAH  A 705 (-3.6A)
SAH  A 705 (-2.7A)
SAH  A 705 (-3.4A)
SAH  A 705 (-3.8A)
 0.74A 1jg3B-5wcjA:
8.8		 1jg3B-5wcjA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAO_A_SAMA245_0
(ERMC'
METHYLTRANSFERASE)		 5wcj METHYLTRANSFERASE-LI
KE PROTEIN 13
(Homo
sapiens) 		5 / 12 GLY A 501
GLY A 503
ILE A 525
ASP A 526
ASP A 551
 SAH  A 705 (-3.5A)
SAH  A 705 (-3.6A)
SAH  A 705 (-3.6A)
None
SAH  A 705 (-3.4A)
 0.59A 1qaoA-5wcjA:
10.0		 1qaoA-5wcjA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_SAMA635_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 5wcj METHYLTRANSFERASE-LI
KE PROTEIN 13
(Homo
sapiens) 		5 / 12 GLY A 505
GLY A 504
GLY A 503
LEU A 530
PHE A 539
 None
None
SAH  A 705 (-3.6A)
None
None
 1.04A 1qzzA-5wcjA:
12.8		 1qzzA-5wcjA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_0
(SUN PROTEIN)		 5wcj METHYLTRANSFERASE-LI
KE PROTEIN 13
(Homo
sapiens) 		5 / 12 GLY A 504
ILE A 525
ASP A 526
ASP A 551
GLY A 552
 None
SAH  A 705 (-3.6A)
None
SAH  A 705 (-3.4A)
SAH  A 705 (-3.8A)
 0.95A 1sqfA-5wcjA:
11.4		 1sqfA-5wcjA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_0
(SUN PROTEIN)		 5wcj METHYLTRANSFERASE-LI
KE PROTEIN 13
(Homo
sapiens) 		5 / 12 GLY A 505
ILE A 525
ASP A 526
ASP A 551
GLY A 552
 None
SAH  A 705 (-3.6A)
None
SAH  A 705 (-3.4A)
SAH  A 705 (-3.8A)
 0.43A 1sqfA-5wcjA:
11.4		 1sqfA-5wcjA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_A_SAMA5635_0
(PROTEIN RDMB)		 5wcj METHYLTRANSFERASE-LI
KE PROTEIN 13
(Homo
sapiens) 		5 / 12 GLY A 505
GLY A 504
GLY A 503
LEU A 530
PHE A 539
 None
None
SAH  A 705 (-3.6A)
None
None
 1.10A 1xdsA-5wcjA:
11.7		 1xdsA-5wcjA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_B_SAMB9635_0
(PROTEIN RDMB)		 5wcj METHYLTRANSFERASE-LI
KE PROTEIN 13
(Homo
sapiens) 		5 / 12 GLY A 505
GLY A 504
GLY A 503
LEU A 530
PHE A 539
 None
None
SAH  A 705 (-3.6A)
None
None
 1.08A 1xdsB-5wcjA:
12.2		 1xdsB-5wcjA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_A_SAMA500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 5wcj METHYLTRANSFERASE-LI
KE PROTEIN 13
(Homo
sapiens) 		6 / 11 PRO A 508
GLU A 524
ILE A 525
ASP A 526
ASP A 551
PHE A 592
 None
SAH  A 705 (-2.7A)
SAH  A 705 (-3.6A)
None
SAH  A 705 (-3.4A)
SAH  A 705 (-4.6A)
 1.19A 2admA-5wcjA:
12.1		 2admA-5wcjA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_B_SAMB500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 5wcj METHYLTRANSFERASE-LI
KE PROTEIN 13
(Homo
sapiens) 		5 / 11 PRO A 508
GLU A 524
ILE A 525
ASP A 551
PHE A 592
 None
SAH  A 705 (-2.7A)
SAH  A 705 (-3.6A)
SAH  A 705 (-3.4A)
SAH  A 705 (-4.6A)
 1.23A 2admB-5wcjA:
12.1		 2admB-5wcjA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A7E_A_SAMA216_1
(CATECHOL
O-METHYLTRANSFERASE)		 5wcj METHYLTRANSFERASE-LI
KE PROTEIN 13
(Homo
sapiens) 		4 / 6 GLY A 501
GLU A 524
ILE A 525
ASP A 575
 SAH  A 705 (-3.5A)
SAH  A 705 (-2.7A)
SAH  A 705 (-3.6A)
SAH  A 705 (-3.6A)
 0.44A 3a7eA-5wcjA:
13.7		 3a7eA-5wcjA:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_3
(PHOSPHOLIPASE A2)		 5wcj METHYLTRANSFERASE-LI
KE PROTEIN 13
(Homo
sapiens) 		4 / 7 VAL A 500
ILE A 612
GLY A 480
LEU A 672
 None
 0.89A 3bjwH-5wcjA:
undetectable		 3bjwH-5wcjA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_A_SAMA501_0
(SPERMIDINE SYNTHASE)		 5wcj METHYLTRANSFERASE-LI
KE PROTEIN 13
(Homo
sapiens) 		6 / 12 HIS A 473
GLY A 501
ILE A 525
ASP A 526
ASP A 551
GLY A 552
 None
SAH  A 705 (-3.5A)
SAH  A 705 (-3.6A)
None
SAH  A 705 (-3.4A)
SAH  A 705 (-3.8A)
 1.36A 3bwcA-5wcjA:
17.0		 3bwcA-5wcjA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_A_SAMA501_0
(SPERMIDINE SYNTHASE)		 5wcj METHYLTRANSFERASE-LI
KE PROTEIN 13
(Homo
sapiens) 		6 / 12 HIS A 474
GLY A 501
ILE A 525
ASP A 526
ASP A 551
GLY A 552
 None
SAH  A 705 (-3.5A)
SAH  A 705 (-3.6A)
None
SAH  A 705 (-3.4A)
SAH  A 705 (-3.8A)
 0.78A 3bwcA-5wcjA:
17.0		 3bwcA-5wcjA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 5wcj METHYLTRANSFERASE-LI
KE PROTEIN 13
(Homo
sapiens) 		6 / 12 HIS A 473
GLY A 501
ILE A 525
ASP A 526
GLY A 552
ASP A 575
 None
SAH  A 705 (-3.5A)
SAH  A 705 (-3.6A)
None
SAH  A 705 (-3.8A)
SAH  A 705 (-3.6A)
 1.49A 3bwcB-5wcjA:
16.7		 3bwcB-5wcjA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 5wcj METHYLTRANSFERASE-LI
KE PROTEIN 13
(Homo
sapiens) 		6 / 12 HIS A 474
GLY A 501
ILE A 525
ASP A 526
GLY A 552
ASP A 575
 None
SAH  A 705 (-3.5A)
SAH  A 705 (-3.6A)
None
SAH  A 705 (-3.8A)
SAH  A 705 (-3.6A)
 0.75A 3bwcB-5wcjA:
16.7		 3bwcB-5wcjA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_G_SAMG302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 5wcj METHYLTRANSFERASE-LI
KE PROTEIN 13
(Homo
sapiens) 		5 / 12 GLY A 501
GLY A 503
LEU A 507
ILE A 525
ASP A 526
 SAH  A 705 (-3.5A)
SAH  A 705 (-3.6A)
None
SAH  A 705 (-3.6A)
None
 0.90A 3cjtG-5wcjA:
13.8		 3cjtG-5wcjA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUU_A_ADNA0_1
(DIMETHYLADENOSINE
TRANSFERASE)		 5wcj METHYLTRANSFERASE-LI
KE PROTEIN 13
(Homo
sapiens) 		6 / 12 VAL A 500
GLY A 501
GLY A 503
GLU A 524
ASP A 526
ASP A 551
 None
SAH  A 705 (-3.5A)
SAH  A 705 (-3.6A)
SAH  A 705 (-2.7A)
None
SAH  A 705 (-3.4A)
 0.59A 3fuuA-5wcjA:
11.5		 3fuuA-5wcjA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRV_A_ADNA300_1
(DIMETHYLADENOSINE
TRANSFERASE)		 5wcj METHYLTRANSFERASE-LI
KE PROTEIN 13
(Homo
sapiens) 		6 / 11 GLY A 501
GLY A 503
GLU A 524
ILE A 525
ASP A 526
ASP A 551
 SAH  A 705 (-3.5A)
SAH  A 705 (-3.6A)
SAH  A 705 (-2.7A)
SAH  A 705 (-3.6A)
None
SAH  A 705 (-3.4A)
 0.25A 3grvA-5wcjA:
13.0		 3grvA-5wcjA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRY_A_SAMA300_0
(DIMETHYLADENOSINE
TRANSFERASE)		 5wcj METHYLTRANSFERASE-LI
KE PROTEIN 13
(Homo
sapiens) 		6 / 12 GLY A 501
GLY A 503
GLU A 524
ILE A 525
ASP A 526
ASP A 551
 SAH  A 705 (-3.5A)
SAH  A 705 (-3.6A)
SAH  A 705 (-2.7A)
SAH  A 705 (-3.6A)
None
SAH  A 705 (-3.4A)
 0.28A 3gryA-5wcjA:
12.3		 3gryA-5wcjA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		 5wcj METHYLTRANSFERASE-LI
KE PROTEIN 13
(Homo
sapiens) 		5 / 11 LEU A 613
LEU A 615
GLU A 648
LEU A 637
GLY A 480
 None
 1.30A 3hm1B-5wcjA:
undetectable		 3hm1B-5wcjA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHT_A_SAMA200_0
(S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE)		 5wcj METHYLTRANSFERASE-LI
KE PROTEIN 13
(Homo
sapiens) 		5 / 12 GLY A 501
GLY A 503
GLY A 505
ASP A 551
PHE A 592
 SAH  A 705 (-3.5A)
SAH  A 705 (-3.6A)
None
SAH  A 705 (-3.4A)
SAH  A 705 (-4.6A)
 0.92A 3ihtA-5wcjA:
13.4		 3ihtA-5wcjA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5wcj METHYLTRANSFERASE-LI
KE PROTEIN 13
(Homo
sapiens) 		4 / 4 GLY A 501
GLU A 524
ASP A 551
ASP A 575
 SAH  A 705 (-3.5A)
SAH  A 705 (-2.7A)
SAH  A 705 (-3.4A)
SAH  A 705 (-3.6A)
 0.47A 3mb5A-5wcjA:
15.4		 3mb5A-5wcjA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 5wcj METHYLTRANSFERASE-LI
KE PROTEIN 13
(Homo
sapiens) 		5 / 12 GLY A 501
GLU A 524
ASP A 551
ASP A 575
VAL A 576
 SAH  A 705 (-3.5A)
SAH  A 705 (-2.7A)
SAH  A 705 (-3.4A)
SAH  A 705 (-3.6A)
SAH  A 705 (-4.1A)
 0.70A 3nvkF-5wcjA:
undetectable
3nvkJ-5wcjA:
14.8		 3nvkF-5wcjA:
23.82
3nvkJ-5wcjA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_1
(MNMC2)		 5wcj METHYLTRANSFERASE-LI
KE PROTEIN 13
(Homo
sapiens) 		4 / 6 HIS A 474
GLU A 524
ASP A 551
ASP A 575
 None
SAH  A 705 (-2.7A)
SAH  A 705 (-3.4A)
SAH  A 705 (-3.6A)
 1.24A 3vywA-5wcjA:
5.5		 3vywA-5wcjA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)		 5wcj METHYLTRANSFERASE-LI
KE PROTEIN 13
(Homo
sapiens) 		4 / 6 GLY A 503
GLU A 524
ASP A 551
ASP A 575
 SAH  A 705 (-3.6A)
SAH  A 705 (-2.7A)
SAH  A 705 (-3.4A)
SAH  A 705 (-3.6A)
 0.69A 3vywC-5wcjA:
12.9		 3vywC-5wcjA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_1
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 5wcj METHYLTRANSFERASE-LI
KE PROTEIN 13
(Homo
sapiens) 		3 / 3 GLU A 524
ASP A 526
ASP A 551
 SAH  A 705 (-2.7A)
None
SAH  A 705 (-3.4A)
 0.27A 4gc9A-5wcjA:
10.0		 4gc9A-5wcjA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5wcj METHYLTRANSFERASE-LI
KE PROTEIN 13
(Homo
sapiens) 		5 / 12 GLY A 501
GLY A 503
ILE A 525
MET A 529
ASP A 551
 SAH  A 705 (-3.5A)
SAH  A 705 (-3.6A)
SAH  A 705 (-3.6A)
SAH  A 705 (-4.4A)
SAH  A 705 (-3.4A)
 0.89A 4iv0B-5wcjA:
12.6		 4iv0B-5wcjA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_B_SAMB601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 5wcj METHYLTRANSFERASE-LI
KE PROTEIN 13
(Homo
sapiens) 		5 / 12 ASP A 554
LEU A 553
ILE A 556
VAL A 523
VAL A 500
 None
 1.16A 5dpdB-5wcjA:
13.5		 5dpdB-5wcjA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 5wcj METHYLTRANSFERASE-LI
KE PROTEIN 13
(Homo
sapiens) 		5 / 7 GLY A 501
GLY A 503
GLU A 524
ASP A 551
ASP A 575
 SAH  A 705 (-3.5A)
SAH  A 705 (-3.6A)
SAH  A 705 (-2.7A)
SAH  A 705 (-3.4A)
SAH  A 705 (-3.6A)
 0.68A 5ergB-5wcjA:
12.4		 5ergB-5wcjA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HJI_A_ADNA401_1
(TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A)		 5wcj METHYLTRANSFERASE-LI
KE PROTEIN 13
(Homo
sapiens) 		5 / 11 LEU A 498
TYR A 569
PHE A 611
GLY A 609
ILE A 604
 None
UNX  A 701 ( 4.4A)
None
None
None
 1.30A 5hjiA-5wcjA:
12.2		 5hjiA-5wcjA:
24.93