SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wdh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_2
(VITAMIN D NUCLEAR
RECEPTOR)		 5wdh KINESIN-LIKE PROTEIN
KIFC1
(Homo
sapiens) 		4 / 6 LEU A 628
ILE A 464
TYR A 622
VAL A 564
 None
 1.14A 1db1A-5wdhA:
undetectable		 1db1A-5wdhA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA732_1
(ALPHA AMYLASE)		 5wdh KINESIN-LIKE PROTEIN
KIFC1
(Homo
sapiens) 		5 / 9 PRO A 435
GLU A 431
GLY A 432
GLY A 425
GLY A 426
 None
None
None
UNX  A 804 ( 3.2A)
UNX  A 804 ( 4.2A)
 1.19A 1mxdA-5wdhA:
undetectable		 1mxdA-5wdhA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1121_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 5wdh KINESIN-LIKE PROTEIN
KIFC1
(Homo
sapiens) 		4 / 5 VAL A 462
SER A 562
VAL A 564
SER A 460
 None
 1.35A 2j9cA-5wdhA:
undetectable
2j9cB-5wdhA:
undetectable
2j9cC-5wdhA:
undetectable		 2j9cA-5wdhA:
14.64
2j9cB-5wdhA:
14.64
2j9cC-5wdhA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_A_FUAA2002_1
(SERUM ALBUMIN)		 5wdh KINESIN-LIKE PROTEIN
KIFC1
(Homo
sapiens) 		4 / 9 ILE A 603
PHE A 656
ALA A 657
VAL A 660
 None
 0.87A 2vufA-5wdhA:
undetectable		 2vufA-5wdhA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FBX_A_ACTA608_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2)		 5wdh KINESIN-LIKE PROTEIN
KIFC1
(Homo
sapiens) 		3 / 3 GLU A 512
VAL A 507
CYH A 509
 None
 1.01A 3fbxA-5wdhA:
undetectable		 3fbxA-5wdhA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5wdh KINESIN-LIKE PROTEIN
KIFC1
(Homo
sapiens) 		4 / 7 GLU A 386
ARG A 316
GLY A 432
ARG A 436
 None
ADP  A 801 (-3.6A)
None
UNX  A 805 ( 2.9A)
 0.92A 4fgzA-5wdhA:
undetectable		 4fgzA-5wdhA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 5wdh KINESIN-LIKE PROTEIN
KIFC1
(Homo
sapiens) 		5 / 9 SER A 414
ALA A 408
LEU A 566
GLY A 568
ALA A 605
 ADP  A 801 (-3.5A)
None
None
None
None
 1.23A 4l6va-5wdhA:
undetectable
4l6vf-5wdhA:
undetectable		 4l6va-5wdhA:
19.31
4l6vf-5wdhA:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_F_EZLF302_1
(ALPHA-CARBONIC
ANHYDRASE)		 5wdh KINESIN-LIKE PROTEIN
KIFC1
(Homo
sapiens) 		4 / 8 HIS A 539
VAL A 541
VAL A 564
LEU A 624
 None
 0.84A 5tt3F-5wdhA:
undetectable		 5tt3F-5wdhA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 5wdh KINESIN-LIKE PROTEIN
KIFC1
(Homo
sapiens) 		3 / 3 TYR A 402
LEU A 394
ASP A 375
 None
 0.82A 5zv2B-5wdhA:
undetectable		 5zv2B-5wdhA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		 5wdh KINESIN-LIKE PROTEIN
KIFC1
(Homo
sapiens) 		5 / 12 VAL A 660
GLU A 570
VAL A 541
PHE A 656
ILE A 464
 None
 1.35A 6becA-5wdhA:
undetectable
6becB-5wdhA:
undetectable
6becC-5wdhA:
undetectable		 6becA-5wdhA:
21.19
6becB-5wdhA:
21.19
6becC-5wdhA:
21.19