SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wdr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)		 5wdr RAS PROTEIN
(Choanoflagellida) 		3 / 3 PHE A  28
LEU A  19
SER A 146
 GNP  A 203 (-4.3A)
None
GNP  A 203 (-3.5A)
 0.74A 1e7aA-5wdrA:
undetectable		 1e7aA-5wdrA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H1D_A_SAMA301_1
(CATECHOL-O-METHYLTRA
NSFERASE)		 5wdr RAS PROTEIN
(Choanoflagellida) 		4 / 4 SER A  89
GLU A 144
SER A 146
ASP A  85
 None
None
GNP  A 203 (-3.5A)
None
 1.38A 1h1dA-5wdrA:
2.8		 1h1dA-5wdrA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VID_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 5wdr RAS PROTEIN
(Choanoflagellida) 		4 / 5 SER A  89
GLU A 144
SER A 146
ASP A  85
 None
None
GNP  A 203 (-3.5A)
None
 1.36A 1vidA-5wdrA:
3.0		 1vidA-5wdrA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 5wdr RAS PROTEIN
(Choanoflagellida) 		5 / 12 THR A  35
GLY A  15
GLY A  13
GLY A  60
ASP A 119
 MG  A 201 ( 3.1A)
GNP  A 203 (-2.9A)
GNP  A 203 (-3.0A)
GNP  A 203 (-3.2A)
GNP  A 203 (-2.0A)
 0.94A 2b25A-5wdrA:
undetectable		 2b25A-5wdrA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CL5_B_SAMB1217_1
(CATECHOL
O-METHYLTRANSFERASE)		 5wdr RAS PROTEIN
(Choanoflagellida) 		4 / 6 SER A  89
GLU A 144
SER A 146
ASP A  85
 None
None
GNP  A 203 (-3.5A)
None
 1.37A 2cl5B-5wdrA:
undetectable		 2cl5B-5wdrA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZB7_A_NCAA901_0
(PROSTAGLANDIN
REDUCTASE 2)		 5wdr RAS PROTEIN
(Choanoflagellida) 		4 / 5 TYR A 158
ILE A  46
LEU A   6
LEU A  53
 None
 1.15A 2zb7A-5wdrA:
2.5		 2zb7A-5wdrA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVJ_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 5wdr RAS PROTEIN
(Choanoflagellida) 		4 / 6 SER A  89
GLU A 144
SER A 146
ASP A  85
 None
None
GNP  A 203 (-3.5A)
None
 1.39A 2zvjA-5wdrA:
undetectable		 2zvjA-5wdrA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_A_EAAA214_1
(GLUTATHIONE
S-TRANSFERASE P)		 5wdr RAS PROTEIN
(Choanoflagellida) 		5 / 9 VAL A  81
GLY A 115
GLN A  61
ASN A 116
GLY A  15
 None
None
GNP  A 203 ( 4.5A)
GNP  A 203 (-3.2A)
GNP  A 203 (-2.9A)
 1.41A 3kmoA-5wdrA:
undetectable		 3kmoA-5wdrA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_C_ADNC301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 5wdr RAS PROTEIN
(Choanoflagellida) 		5 / 9 ALA A 130
LEU A 113
LEU A  90
ASP A  91
ILE A  93
 None
 1.15A 3wdmC-5wdrA:
undetectable		 3wdmC-5wdrA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUC_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 5wdr RAS PROTEIN
(Choanoflagellida) 		4 / 4 SER A  89
GLU A 144
SER A 146
ASP A  85
 None
None
GNP  A 203 (-3.5A)
None
 1.36A 4xucA-5wdrA:
3.0		 4xucA-5wdrA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 5wdr RAS PROTEIN
(Choanoflagellida) 		4 / 5 SER A  89
GLU A 144
SER A 146
ASP A  85
 None
None
GNP  A 203 (-3.5A)
None
 1.37A 5fhrA-5wdrA:
undetectable		 5fhrA-5wdrA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_B_SAMB303_1
(CATECHOL
O-METHYLTRANSFERASE)		 5wdr RAS PROTEIN
(Choanoflagellida) 		4 / 5 SER A  89
GLU A 144
SER A 146
ASP A  85
 None
None
GNP  A 203 (-3.5A)
None
 1.37A 5fhrB-5wdrA:
undetectable		 5fhrB-5wdrA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		 5wdr RAS PROTEIN
(Choanoflagellida) 		3 / 3 TYR A  32
TYR A  64
GLN A  61
 GNP  A 203 (-3.2A)
None
GNP  A 203 ( 4.5A)
 1.17A 5jsdA-5wdrA:
undetectable
5jsdB-5wdrA:
undetectable		 5jsdA-5wdrA:
13.22
5jsdB-5wdrA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		 5wdr RAS PROTEIN
(Choanoflagellida) 		3 / 3 TYR A  32
TYR A  64
GLN A  61
 GNP  A 203 (-3.2A)
None
GNP  A 203 ( 4.5A)
 1.17A 5jsdB-5wdrA:
undetectable
5jsdC-5wdrA:
undetectable		 5jsdB-5wdrA:
13.22
5jsdC-5wdrA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_1
(REGULATORY PROTEIN
TETR)		 5wdr RAS PROTEIN
(Choanoflagellida) 		4 / 7 GLY A 115
GLN A  88
ASP A  85
ASP A 119
 None
None
None
GNP  A 203 (-2.0A)
 1.12A 5vlmE-5wdrA:
undetectable		 5vlmE-5wdrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA901_0
(MRNA CAPPING ENZYME
P5)		 5wdr RAS PROTEIN
(Choanoflagellida) 		5 / 11 VAL A 114
GLY A 115
SER A 146
ALA A 156
LEU A  79
 None
None
GNP  A 203 (-3.5A)
None
None
 1.23A 5x6yA-5wdrA:
2.0		 5x6yA-5wdrA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC901_0
(MRNA CAPPING ENZYME
P5)		 5wdr RAS PROTEIN
(Choanoflagellida) 		5 / 11 VAL A 114
GLY A 115
SER A 146
ALA A 156
LEU A  79
 None
None
GNP  A 203 (-3.5A)
None
None
 1.24A 5x6yC-5wdrA:
undetectable		 5x6yC-5wdrA:
12.69