SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wdx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHO_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		5 / 9 THR A 305
GLY A 304
GLY A 271
PHE A 273
LEU A 274
 None
 1.32A 1jhoA-5wdxA:
undetectable		 1jhoA-5wdxA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NCW_H_BEZH601_0
(IMMUNOGLOBULIN IGG2A)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		5 / 9 ALA A 297
TRP A 501
LEU A 301
GLY A 302
GLY A 271
 None
 1.29A 1ncwH-5wdxA:
undetectable
1ncwL-5wdxA:
undetectable		 1ncwH-5wdxA:
17.60
1ncwL-5wdxA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_A_SAMA501_0
(BIOTIN SYNTHASE)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		5 / 12 THR A  46
GLY A  45
ILE A 167
LEU A 126
LEU A 144
 None
 1.17A 1r30A-5wdxA:
undetectable		 1r30A-5wdxA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_B_SAMB501_0
(BIOTIN SYNTHASE)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		5 / 12 THR A  46
GLY A  45
ILE A 167
LEU A 126
LEU A 144
 None
 1.17A 1r30B-5wdxA:
undetectable		 1r30B-5wdxA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_B_PODB700_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		5 / 12 CYH A 622
ALA A 625
LEU A 627
VAL A 535
ALA A 534
 None
 1.17A 1sa1A-5wdxA:
undetectable
1sa1B-5wdxA:
undetectable		 1sa1A-5wdxA:
21.00
1sa1B-5wdxA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_D_PODD701_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		5 / 12 CYH A 622
ALA A 625
LEU A 627
VAL A 535
ALA A 534
 None
 1.13A 1sa1C-5wdxA:
undetectable
1sa1D-5wdxA:
undetectable		 1sa1C-5wdxA:
21.00
1sa1D-5wdxA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		10 / 12 HIS A  57
ARG A 123
ILE A 132
LEU A 135
GLY A 137
PHE A 154
ARG A 155
ALA A 156
ALA A 157
VAL A 158
 None
 0.60A 2oc8A-5wdxA:
25.5		 2oc8A-5wdxA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		8 / 12 HIS A  57
ARG A 123
LEU A 135
GLY A 137
SER A 139
PHE A 154
ARG A 155
ALA A 156
 None
 0.73A 2oc8A-5wdxA:
25.5		 2oc8A-5wdxA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_C_CSCC1383_1
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		5 / 12 LEU A 522
THR A 519
TYR A 201
GLN A 198
HIS A 203
 None
 1.43A 2vavC-5wdxA:
undetectable		 2vavC-5wdxA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_D_CSCD1383_1
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		5 / 12 LEU A 522
THR A 519
TYR A 201
GLN A 198
HIS A 203
 None
 1.42A 2vavD-5wdxA:
undetectable		 2vavD-5wdxA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAX_D_CSCD1383_1
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		5 / 12 LEU A 522
THR A 519
TYR A 201
GLN A 198
HIS A 203
 None
 1.46A 2vaxD-5wdxA:
undetectable		 2vaxD-5wdxA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAX_J_CSCJ1385_1
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		5 / 12 LEU A 522
THR A 519
TYR A 201
GLN A 198
HIS A 203
 None
 1.48A 2vaxJ-5wdxA:
undetectable		 2vaxJ-5wdxA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAX_K_CSCK1385_1
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		5 / 12 LEU A 522
THR A 519
TYR A 201
GLN A 198
HIS A 203
 None
 1.50A 2vaxK-5wdxA:
undetectable		 2vaxK-5wdxA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VJ1_A_BEZA1303_0
(SARS CORONAVIRUS
MAIN PROTEINASE)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		3 / 3 HIS A  57
MET A 485
MET A 630
 None
 1.15A 2vj1A-5wdxA:
6.7		 2vj1A-5wdxA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1200_1
(SERUM ALBUMIN)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		4 / 5 ILE A 336
HIS A 333
ARG A 467
GLY A 468
 None
 1.26A 3b9mA-5wdxA:
undetectable		 3b9mA-5wdxA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		5 / 10 CYH A 289
ILE A 288
GLY A 302
VAL A 315
LEU A 320
 None
 1.16A 3em0A-5wdxA:
undetectable		 3em0A-5wdxA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_A_30BA500_1
(GENOME POLYPROTEIN)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		10 / 12 HIS A  57
GLY A  58
ASP A  81
GLY A 137
SER A 139
PHE A 154
ALA A 156
ALA A 157
CYH A 159
ASP A 168
 None
 0.50A 3keeA-5wdxA:
25.2		 3keeA-5wdxA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		7 / 12 GLN A  41
HIS A  57
GLY A 137
SER A 139
PHE A 154
ALA A 156
ALA A 157
 None
 0.66A 3keeB-5wdxA:
25.3		 3keeB-5wdxA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		8 / 12 HIS A  57
GLY A  58
ASP A  81
GLY A 137
SER A 139
PHE A 154
ALA A 156
ALA A 157
 None
 0.33A 3keeB-5wdxA:
25.3		 3keeB-5wdxA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		3 / 3 PHE A  43
TYR A  56
LEU A 135
 None
 0.28A 3keeB-5wdxA:
25.3		 3keeB-5wdxA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_C_30BC500_1
(GENOME POLYPROTEIN)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		9 / 12 HIS A  57
GLY A  58
ASP A  81
GLY A 137
SER A 139
PHE A 154
ALA A 156
ALA A 157
ASP A 168
 None
 0.31A 3keeC-5wdxA:
25.4		 3keeC-5wdxA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_1
(GENOME POLYPROTEIN)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		8 / 12 GLN A  41
HIS A  57
GLY A 137
SER A 139
PHE A 154
ALA A 156
ALA A 157
ASP A 168
 None
 0.66A 3keeD-5wdxA:
25.3		 3keeD-5wdxA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_1
(GENOME POLYPROTEIN)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		9 / 12 HIS A  57
GLY A  58
ASP A  81
GLY A 137
SER A 139
PHE A 154
ALA A 156
ALA A 157
ASP A 168
 None
 0.34A 3keeD-5wdxA:
25.3		 3keeD-5wdxA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_1
(GENOME POLYPROTEIN)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		6 / 12 LYS A 136
GLY A 137
PHE A 154
ALA A 156
ALA A 157
ASP A 168
 None
 0.95A 3keeD-5wdxA:
25.3		 3keeD-5wdxA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_0
(16S RRNA METHYLASE)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		5 / 12 GLY A 141
ALA A 111
ALA A   7
LEU A  36
PHE A  43
 None
 1.07A 3p2kC-5wdxA:
undetectable		 3p2kC-5wdxA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_A_NCAA302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		4 / 8 TYR A 218
LEU A 202
ALA A 204
SER A 208
 None
 1.04A 3rodA-5wdxA:
undetectable		 3rodA-5wdxA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		6 / 12 GLN A  41
ARG A 123
GLY A 137
PHE A 154
ALA A 156
ALA A 157
 None
 0.58A 3sudA-5wdxA:
27.2		 3sudA-5wdxA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		8 / 12 HIS A  57
GLY A  58
ASP A  81
ARG A 123
GLY A 137
PHE A 154
ALA A 156
ALA A 157
 None
 0.44A 3sudA-5wdxA:
27.2		 3sudA-5wdxA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		4 / 4 PHE A  43
TYR A  56
ILE A 132
LEU A 135
 None
 0.60A 3sudA-5wdxA:
27.2		 3sudA-5wdxA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		8 / 12 GLN A  41
PHE A  43
TYR A  56
HIS A  57
ILE A 132
GLY A 137
PHE A 154
ALA A 156
 None
 0.72A 3sudB-5wdxA:
27.5		 3sudB-5wdxA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		9 / 12 PHE A  43
TYR A  56
HIS A  57
GLY A  58
ASP A  81
ILE A 132
GLY A 137
PHE A 154
ALA A 156
 None
 0.50A 3sudB-5wdxA:
27.5		 3sudB-5wdxA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		7 / 12 GLN A  41
GLY A  58
ARG A 123
PHE A 154
ARG A 155
ALA A 156
ALA A 157
 None
 1.02A 3sudC-5wdxA:
26.7		 3sudC-5wdxA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		9 / 12 GLN A  41
HIS A  57
GLY A  58
ARG A 123
ILE A 132
GLY A 137
PHE A 154
ALA A 156
ALA A 157
 None
 0.70A 3sudC-5wdxA:
26.7		 3sudC-5wdxA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		7 / 12 GLY A  58
ASP A  81
ARG A 123
PHE A 154
ARG A 155
ALA A 156
ALA A 157
 None
 0.96A 3sudC-5wdxA:
26.7		 3sudC-5wdxA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		9 / 12 HIS A  57
GLY A  58
ASP A  81
ARG A 123
ILE A 132
GLY A 137
PHE A 154
ALA A 156
ALA A 157
 None
 0.58A 3sudC-5wdxA:
26.7		 3sudC-5wdxA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		8 / 12 GLN A  41
HIS A  57
GLY A  58
GLY A 137
PHE A 154
ALA A 156
ALA A 157
ASP A 168
 None
 0.55A 3sudD-5wdxA:
27.6		 3sudD-5wdxA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		8 / 12 HIS A  57
GLY A  58
ASP A  81
GLY A 137
PHE A 154
ALA A 156
ALA A 157
ASP A 168
 None
 0.32A 3sudD-5wdxA:
27.6		 3sudD-5wdxA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		9 / 12 GLN A  41
HIS A  57
GLY A  58
ILE A 132
GLY A 137
SER A 139
PHE A 154
ALA A 156
ALA A 157
 None
 0.66A 3sueA-5wdxA:
27.6		 3sueA-5wdxA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		9 / 12 HIS A  57
GLY A  58
ASP A  81
ILE A 132
GLY A 137
SER A 139
PHE A 154
ALA A 156
ALA A 157
 None
 0.47A 3sueA-5wdxA:
27.6		 3sueA-5wdxA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		4 / 4 PHE A  43
TYR A  56
ARG A 123
LEU A 135
 None
 0.42A 3sueA-5wdxA:
27.6		 3sueA-5wdxA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		7 / 12 GLN A  41
ARG A 123
GLY A 137
SER A 139
PHE A 154
ALA A 156
ALA A 157
 None
 0.65A 3sueB-5wdxA:
27.4		 3sueB-5wdxA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		9 / 12 HIS A  57
GLY A  58
ASP A  81
ARG A 123
GLY A 137
SER A 139
PHE A 154
ALA A 156
ALA A 157
 None
 0.52A 3sueB-5wdxA:
27.4		 3sueB-5wdxA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		7 / 12 GLN A  41
GLY A  58
GLY A 137
SER A 139
PHE A 154
ALA A 156
ALA A 157
 None
 0.67A 3sueC-5wdxA:
27.0		 3sueC-5wdxA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		9 / 12 HIS A  57
GLY A  58
ASP A  81
GLY A 137
SER A 139
PHE A 154
ALA A 156
ALA A 157
ASP A 168
 None
 0.69A 3sueC-5wdxA:
27.0		 3sueC-5wdxA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		4 / 5 PHE A  43
TYR A  56
ILE A 132
LEU A 135
 None
 0.64A 3sueC-5wdxA:
27.0		 3sueC-5wdxA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		8 / 12 GLN A  41
PHE A  43
HIS A  57
ARG A 123
GLY A 137
SER A 139
PHE A 154
ALA A 156
 None
 0.64A 3sueD-5wdxA:
27.3		 3sueD-5wdxA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		9 / 12 PHE A  43
HIS A  57
GLY A  58
ASP A  81
ARG A 123
GLY A 137
SER A 139
PHE A 154
ALA A 156
 None
 0.46A 3sueD-5wdxA:
27.3		 3sueD-5wdxA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		6 / 12 ARG A 123
LEU A 135
LYS A 136
GLY A 137
PHE A 154
ALA A 157
 None
 1.29A 3sufA-5wdxA:
27.1		 3sufA-5wdxA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		8 / 12 GLN A  41
HIS A  57
LEU A 135
GLY A 137
SER A 139
PHE A 154
ALA A 156
ALA A 157
 None
 0.75A 3sufA-5wdxA:
27.1		 3sufA-5wdxA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		10 / 12 HIS A  57
GLY A  58
ASP A  81
ARG A 123
LEU A 135
GLY A 137
SER A 139
PHE A 154
ALA A 156
ALA A 157
 None
 0.56A 3sufA-5wdxA:
27.1		 3sufA-5wdxA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		8 / 12 GLN A  41
PHE A  43
GLY A  58
ILE A 132
GLY A 137
SER A 139
PHE A 154
ALA A 156
 None
 0.76A 3sufB-5wdxA:
27.5		 3sufB-5wdxA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		11 / 12 PHE A  43
VAL A  55
HIS A  57
GLY A  58
ASP A  81
ILE A 132
GLY A 137
SER A 139
PHE A 154
ALA A 156
ALA A 157
 None
 0.49A 3sufB-5wdxA:
27.5		 3sufB-5wdxA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		10 / 11 GLN A  41
PHE A  43
TYR A  56
HIS A  57
GLY A  58
GLY A 137
SER A 139
PHE A 154
ALA A 156
ALA A 157
 None
 0.60A 3sufC-5wdxA:
26.8		 3sufC-5wdxA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		10 / 11 PHE A  43
TYR A  56
HIS A  57
GLY A  58
ASP A  81
GLY A 137
SER A 139
PHE A 154
ALA A 156
ALA A 157
 None
 0.37A 3sufC-5wdxA:
26.8		 3sufC-5wdxA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUG_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		6 / 12 ARG A 123
GLY A 137
PHE A 154
ARG A 155
ALA A 157
ASP A 168
 None
 1.01A 3sugA-5wdxA:
27.1		 3sugA-5wdxA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUG_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		7 / 12 HIS A  57
GLY A  58
ARG A 123
GLY A 137
PHE A 154
ALA A 157
ASP A 168
 None
 0.76A 3sugA-5wdxA:
27.1		 3sugA-5wdxA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUG_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		7 / 12 HIS A  57
GLY A  58
ASP A  81
ARG A 123
GLY A 137
PHE A 154
ALA A 157
 None
 0.52A 3sugA-5wdxA:
27.1		 3sugA-5wdxA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_B_ADNB301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		5 / 10 ARG A 512
GLY A 304
LEU A 228
LEU A 307
ILE A 287
 None
 1.09A 3wdmB-5wdxA:
undetectable		 3wdmB-5wdxA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_1
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		5 / 11 SER A 424
VAL A 408
LEU A 365
ALA A 410
VAL A 389
 None
 1.13A 4e0fA-5wdxA:
undetectable		 4e0fA-5wdxA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		4 / 7 GLU A 338
GLU A 337
GLY A 463
ARG A 462
 None
 0.83A 4fgzA-5wdxA:
undetectable		 4fgzA-5wdxA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_2
(TUBULIN BETA CHAIN)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		5 / 12 CYH A 622
ALA A 625
LEU A 627
VAL A 535
ALA A 534
 None
 1.15A 4x1iB-5wdxA:
undetectable		 4x1iB-5wdxA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		4 / 8 ARG A 469
ASP A 423
PHE A 422
ASP A 421
 None
 1.17A 4xqgB-5wdxA:
2.2		 4xqgB-5wdxA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_A_ACTA1923_0
(BETA-XYLOSIDASE)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		3 / 3 ASP A 285
ARG A 316
TYR A 223
 None
 1.00A 5a7mA-5wdxA:
undetectable		 5a7mA-5wdxA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_B_ACTB1924_0
(BETA-XYLOSIDASE)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		3 / 3 ASP A 285
ARG A 316
TYR A 223
 None
 0.99A 5a7mB-5wdxA:
2.5		 5a7mB-5wdxA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		4 / 6 SER A  77
GLU A  79
GLY A  45
GLY A 140
 None
 0.92A 5cdnC-5wdxA:
undetectable
5cdnD-5wdxA:
undetectable		 5cdnC-5wdxA:
22.31
5cdnD-5wdxA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		4 / 6 SER A  77
GLU A  79
GLY A  45
GLY A 140
 None
 0.94A 5cdnT-5wdxA:
undetectable
5cdnU-5wdxA:
undetectable		 5cdnT-5wdxA:
22.31
5cdnU-5wdxA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_D_6ZPD902_1
(GLUTAMATE RECEPTOR 2)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		5 / 10 SER A 439
PHE A 444
ASP A 441
PRO A 442
LEU A 598
 None
 1.47A 5l1fD-5wdxA:
3.9		 5l1fD-5wdxA:
21.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6C2M_A_SUEA1202_0
(NS3 PROTEASE)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		9 / 12 GLN A  41
PHE A  43
ARG A 123
ILE A 132
LEU A 135
GLY A 137
SER A 139
PHE A 154
ALA A 156
 None
 0.69A 6c2mA-5wdxA:
27.2		 6c2mA-5wdxA:
37.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6C2M_A_SUEA1202_0
(NS3 PROTEASE)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		10 / 12 PHE A  43
HIS A  57
GLY A  58
ARG A 123
ILE A 132
LEU A 135
GLY A 137
SER A 139
PHE A 154
ALA A 156
 None
 0.47A 6c2mA-5wdxA:
27.2		 6c2mA-5wdxA:
37.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6C2M_A_SUEA1202_1
(NS3 PROTEASE)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		5 / 9 VAL A  55
ASP A  81
ALA A 157
VAL A 158
ASP A 168
 None
 0.42A 6c2mA-5wdxA:
27.2		 6c2mA-5wdxA:
37.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6C2M_B_SUEB1202_0
(NS3 PROTEASE)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		8 / 12 GLN A  41
HIS A  57
ARG A 123
ILE A 132
GLY A 137
SER A 139
PHE A 154
ALA A 156
 None
 0.76A 6c2mB-5wdxA:
27.5		 6c2mB-5wdxA:
37.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6C2M_B_SUEB1202_0
(NS3 PROTEASE)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		9 / 12 PHE A  43
HIS A  57
GLY A  58
ARG A 123
ILE A 132
GLY A 137
SER A 139
PHE A 154
ALA A 156
 None
 0.56A 6c2mB-5wdxA:
27.5		 6c2mB-5wdxA:
37.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6C2M_B_SUEB1202_1
(NS3 PROTEASE)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		6 / 9 VAL A  55
ASP A  81
LEU A 135
ALA A 157
VAL A 158
ASP A 168
 None
 0.41A 6c2mB-5wdxA:
27.5		 6c2mB-5wdxA:
37.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6C2M_C_SUEC1203_0
(NS3 PROTEASE)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		9 / 12 GLN A  41
HIS A  57
ARG A 123
GLY A 137
SER A 139
PHE A 154
ALA A 156
ALA A 157
VAL A 158
 None
 0.65A 6c2mC-5wdxA:
27.4		 6c2mC-5wdxA:
37.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6C2M_C_SUEC1203_0
(NS3 PROTEASE)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		9 / 12 HIS A  57
ASP A  81
ARG A 123
GLY A 137
SER A 139
PHE A 154
ALA A 156
ALA A 157
VAL A 158
 None
 0.40A 6c2mC-5wdxA:
27.4		 6c2mC-5wdxA:
37.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6C2M_C_SUEC1203_1
(NS3 PROTEASE)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		6 / 9 PHE A  43
VAL A  55
GLY A  58
ILE A 132
LEU A 135
ASP A 168
 None
 0.49A 6c2mC-5wdxA:
27.4		 6c2mC-5wdxA:
37.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6C2M_C_SUEC1203_1
(NS3 PROTEASE)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		5 / 9 PHE A  43
VAL A  55
LEU A 135
ARG A 155
ASP A 168
 None
 1.42A 6c2mC-5wdxA:
27.4		 6c2mC-5wdxA:
37.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6C2M_D_SUED1202_0
(NS3 PROTEASE)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		7 / 12 GLN A  41
HIS A  57
GLY A  58
GLY A 137
PHE A 154
ALA A 156
ALA A 157
 None
 0.62A 6c2mD-5wdxA:
27.2		 6c2mD-5wdxA:
37.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6C2M_D_SUED1202_0
(NS3 PROTEASE)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		8 / 12 HIS A  57
GLY A  58
ARG A 123
ILE A 132
GLY A 137
PHE A 154
ALA A 156
ALA A 157
 None
 0.53A 6c2mD-5wdxA:
27.2		 6c2mD-5wdxA:
37.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_1
(-)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		5 / 12 VAL A 476
ASN A 429
GLU A 480
PRO A 452
GLY A 479
 None
 1.33A 6gnfA-5wdxA:
undetectable		 6gnfA-5wdxA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		5 / 12 VAL A 476
ASN A 429
GLU A 480
PRO A 452
GLY A 479
 None
 1.34A 6gnfC-5wdxA:
undetectable		 6gnfC-5wdxA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_N_PCFN606_0
(CYTOCHROME B)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		5 / 12 ALA A 116
THR A 134
PHE A 154
VAL A 143
VAL A 151
 None
 1.50A 6hu9N-5wdxA:
undetectable		 6hu9N-5wdxA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NCS_A_ACTA303_0
(N-ACETYLNEURAMINIC
ACID (SIALIC ACID)
SYNTHETASE)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		3 / 3 ILE A 265
THR A 266
PRO A 215
 None
 0.44A 6ncsA-5wdxA:
undetectable		 6ncsA-5wdxA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5wdx JFH-1 NS3
(Hepacivirus
C) 		3 / 3 ARG A 514
PHE A 531
PHE A 517
 None
 0.98A 6nknC-5wdxA:
undetectable
6nknJ-5wdxA:
undetectable		 6nknC-5wdxA:
17.82
6nknJ-5wdxA:
9.95