SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wea'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_1
(ADENOSINE DEAMINASE)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		5 / 12 HIS A 764
PHE A 676
LEU A 768
GLU A 745
HIS A 742
 None
 1.44A 1a4lB-5weaA:
undetectable		 1a4lB-5weaA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		6 / 12 PHE A 666
ILE A 687
LEU A 642
MET A 645
GLU A 648
CYH A 626
 None
 1.14A 1lxfC-5weaA:
undetectable		 1lxfC-5weaA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_B_AG2B7001_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		4 / 6 ILE A 664
GLU A 683
LEU A 642
LEU A 649
 None
 1.00A 1mt1B-5weaA:
undetectable
1mt1C-5weaA:
undetectable		 1mt1B-5weaA:
26.17
1mt1C-5weaA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_A_AICA5001_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		4 / 8 GLN A 757
HIS A 753
SER A 798
TYR A 804
 A  B   6 ( 3.7A)
A  B   5 ( 4.1A)
A  B   5 ( 4.5A)
A  B   4 ( 4.8A)
 0.97A 1nx9A-5weaA:
4.2		 1nx9A-5weaA:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_C_AICC5003_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		4 / 8 GLN A 757
HIS A 753
SER A 798
TYR A 804
 A  B   6 ( 3.7A)
A  B   5 ( 4.1A)
A  B   5 ( 4.5A)
A  B   4 ( 4.8A)
 0.97A 1nx9C-5weaA:
undetectable		 1nx9C-5weaA:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD507_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		4 / 7 PHE A 442
ALA A 481
ILE A 567
ILE A 485
 None
 0.93A 1oniD-5weaA:
1.5
1oniF-5weaA:
undetectable		 1oniD-5weaA:
10.48
1oniF-5weaA:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		4 / 7 LYS A  51
LEU A 140
GLN A 141
LEU A 162
 None
 1.06A 2einC-5weaA:
undetectable
2einJ-5weaA:
undetectable		 2einC-5weaA:
13.97
2einJ-5weaA:
7.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_F_RBFF204_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		4 / 8 TYR A 279
TYR A 311
ARG A 315
VAL A 308
 None
U  B   8 ( 4.1A)
U  B   8 ( 4.4A)
None
 0.99A 2fl5E-5weaA:
undetectable
2fl5F-5weaA:
undetectable		 2fl5E-5weaA:
16.91
2fl5F-5weaA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OBV_A_SAMA501_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-1)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		4 / 8 HIS A 807
SER A 798
SER A 763
ASP A 597
 None
A  B   5 ( 4.5A)
None
None
 1.03A 2obvA-5weaA:
undetectable		 2obvA-5weaA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P02_A_SAMA2_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		4 / 8 HIS A 807
SER A 798
SER A 763
ASP A 597
 None
A  B   5 ( 4.5A)
None
None
 1.12A 2p02A-5weaA:
undetectable		 2p02A-5weaA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA803_0
(FERROCHELATASE)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		4 / 5 LEU A 325
PRO A 326
LEU A 341
ILE A 231
 None
 0.80A 2qd4A-5weaA:
5.1		 2qd4A-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		3 / 3 ASN A 216
ARG A 207
ASP A 747
 None
 0.89A 2qe6A-5weaA:
undetectable		 2qe6A-5weaA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		3 / 3 ASN A 216
ARG A 207
ASP A 747
 None
 0.87A 2qe6B-5weaA:
undetectable		 2qe6B-5weaA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA509_0
(CHORISMATE SYNTHASE)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		3 / 3 ARG A 460
GLN A 496
PRO A 458
 None
 0.95A 2qhfA-5weaA:
undetectable		 2qhfA-5weaA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		4 / 7 LEU A 642
LEU A 649
ILE A 664
GLU A 683
 None
 1.04A 2qqdA-5weaA:
undetectable
2qqdE-5weaA:
0.8		 2qqdA-5weaA:
19.48
2qqdE-5weaA:
26.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_L_TRPL1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		5 / 9 GLN A 640
HIS A 682
ILE A 687
VAL A 646
VAL A 614
 None
 1.44A 3fi0L-5weaA:
undetectable		 3fi0L-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		3 / 3 ASN A  99
MET A 172
PHE A  94
 None
 0.99A 3g4lD-5weaA:
undetectable		 3g4lD-5weaA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGX_A_SALA102_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		4 / 7 VAL A 671
ILE A 639
ILE A 638
GLN A 675
 None
 1.00A 3hgxA-5weaA:
undetectable		 3hgxA-5weaA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		4 / 6 TYR A 279
VAL A 234
ILE A 346
ARG A 255
 None
 1.00A 3pyyA-5weaA:
undetectable		 3pyyA-5weaA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		5 / 12 VAL A 574
LEU A 565
ALA A 801
ILE A 418
VAL A 797
 None
None
None
None
A  B   5 ( 3.8A)
 1.03A 3w67C-5weaA:
undetectable		 3w67C-5weaA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF512_1
(HEMOLYTIC LECTIN
CEL-III)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		4 / 6 THR A 599
GLY A 670
ASP A 669
ILE A 799
 None
 0.74A 3w9tF-5weaA:
undetectable		 3w9tF-5weaA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_ACTB1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		4 / 7 PRO A 731
ILE A 730
GLY A 410
VAL A 736
 None
 0.96A 4a3uB-5weaA:
2.3		 4a3uB-5weaA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		5 / 12 LEU A 779
LEU A 782
LEU A 786
CYH A 787
ILE A 665
 None
 0.73A 4a7aB-5weaA:
undetectable		 4a7aB-5weaA:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		4 / 4 PHE A 587
VAL A 591
ALA A 620
PHE A 653
 None
 0.32A 4f3tA-5weaA:
59.2		 4f3tA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		6 / 6 LEU A 650
TYR A 654
LYS A 660
LEU A 694
GLU A 695
TYR A 698
 IPH  A 901 (-4.7A)
None
None
IPH  A 901 (-3.9A)
IPH  A 901 (-3.6A)
IPH  A 901 ( 4.9A)
 0.83A 4f3tA-5weaA:
59.2		 4f3tA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		4 / 4 LEU A 325
PRO A 326
LEU A 341
ILE A 231
 None
 0.73A 4f4dB-5weaA:
4.5		 4f4dB-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		4 / 5 LEU A 325
PRO A 326
LEU A 341
ILE A 231
 None
 0.66A 4klrA-5weaA:
4.5		 4klrA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		4 / 8 HIS A 807
SER A 798
SER A 763
ASP A 597
 None
A  B   5 ( 4.5A)
None
None
 1.03A 4kttA-5weaA:
undetectable		 4kttA-5weaA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		4 / 8 HIS A 807
SER A 798
SER A 763
ASP A 597
 None
A  B   5 ( 4.5A)
None
None
 1.08A 4kttC-5weaA:
undetectable		 4kttC-5weaA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		4 / 8 HIS A 807
SER A 798
SER A 763
ASP A 597
 None
A  B   5 ( 4.5A)
None
None
 1.13A 4ndnA-5weaA:
undetectable		 4ndnA-5weaA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		4 / 7 HIS A 711
PRO A 762
SER A 209
PHE A  44
 None
 1.33A 4ndnC-5weaA:
undetectable		 4ndnC-5weaA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		4 / 5 LYS A 660
LEU A 694
GLU A 695
TYR A 698
 None
IPH  A 901 (-3.9A)
IPH  A 901 (-3.6A)
IPH  A 901 ( 4.9A)
 1.06A 4olaA-5weaA:
61.6		 4olaA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		4 / 5 TYR A 654
LEU A 694
GLU A 695
TYR A 698
 None
IPH  A 901 (-3.9A)
IPH  A 901 (-3.6A)
IPH  A 901 ( 4.9A)
 0.46A 4olaA-5weaA:
61.6		 4olaA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA902_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		5 / 5 TYR A 654
LYS A 660
LEU A 694
GLU A 695
TYR A 698
 None
None
IPH  A 901 (-3.9A)
IPH  A 901 (-3.6A)
IPH  A 901 ( 4.9A)
 0.93A 4olbA-5weaA:
59.0		 4olbA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		5 / 6 LEU A 650
ILE A 651
LEU A 694
GLU A 695
TYR A 698
 IPH  A 901 (-4.7A)
IPH  A 901 ( 4.7A)
IPH  A 901 (-3.9A)
IPH  A 901 (-3.6A)
IPH  A 901 ( 4.9A)
 0.67A 4w5nA-5weaA:
60.4		 4w5nA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		5 / 6 LEU A 650
LYS A 660
LEU A 694
GLU A 695
TYR A 698
 IPH  A 901 (-4.7A)
None
IPH  A 901 (-3.9A)
IPH  A 901 (-3.6A)
IPH  A 901 ( 4.9A)
 0.76A 4w5nA-5weaA:
60.4		 4w5nA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		4 / 4 TYR A 174
THR A 183
GLY A 201
LEU A 382
 None
 0.47A 4w5nA-5weaA:
60.4		 4w5nA-5weaA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4W5O_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		7 / 7 ARG A 688
CYH A 691
ILE A 692
GLN A 699
PRO A 700
ILE A 702
ASP A 771
 None
 0.66A 4w5oA-5weaA:
58.7		 4w5oA-5weaA:
99.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		4 / 4 TYR A 654
LYS A 660
GLU A 695
TYR A 698
 None
None
IPH  A 901 (-3.6A)
IPH  A 901 ( 4.9A)
 0.92A 4w5oA-5weaA:
58.7		 4w5oA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		5 / 5 PHE A 587
PRO A 590
VAL A 591
ALA A 620
PHE A 653
 None
 0.31A 4w5oA-5weaA:
58.7		 4w5oA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA907_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		4 / 5 ALA A 543
LYS A 570
THR A 852
TYR A 857
 None
A  B   1 ( 4.0A)
None
None
 0.55A 4w5oA-5weaA:
58.7		 4w5oA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		6 / 6 ARG A 688
CYH A 691
ILE A 692
GLN A 699
ILE A 702
ASP A 771
 None
 0.63A 4w5qA-5weaA:
53.2		 4w5qA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		5 / 5 TYR A 654
LYS A 660
PRO A 661
LEU A 694
TYR A 698
 None
None
None
IPH  A 901 (-3.9A)
IPH  A 901 ( 4.9A)
 0.71A 4w5qA-5weaA:
53.2		 4w5qA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		4 / 4 PHE A 587
VAL A 591
ALA A 620
PHE A 653
 None
 0.25A 4w5qA-5weaA:
53.2		 4w5qA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		4 / 6 ALA A 543
LYS A 570
THR A 852
TYR A 857
 None
A  B   1 ( 4.0A)
None
None
 1.41A 4w5qA-5weaA:
53.2		 4w5qA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		5 / 6 ASP A 537
ALA A 543
LYS A 570
THR A 852
TYR A 857
 None
None
A  B   1 ( 4.0A)
None
None
 0.67A 4w5qA-5weaA:
53.2		 4w5qA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		4 / 6 ASP A 537
ALA A 543
LYS A 570
THR A 855
 None
None
A  B   1 ( 4.0A)
None
 1.22A 4w5qA-5weaA:
53.2		 4w5qA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5R_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		4 / 4 TYR A 654
LYS A 660
GLU A 695
TYR A 698
 None
None
IPH  A 901 (-3.6A)
IPH  A 901 ( 4.9A)
 0.85A 4w5rA-5weaA:
58.0		 4w5rA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5R_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		4 / 4 PHE A 587
VAL A 591
ALA A 620
PHE A 653
 None
 0.28A 4w5rA-5weaA:
58.0		 4w5rA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5R_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		5 / 6 ASP A 537
ALA A 543
LYS A 570
THR A 852
TYR A 857
 None
None
A  B   1 ( 4.0A)
None
None
 0.60A 4w5rA-5weaA:
58.0		 4w5rA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		6 / 6 ARG A 688
CYH A 691
ILE A 692
GLN A 699
ILE A 702
ASP A 771
 None
 0.71A 4w5tA-5weaA:
48.7		 4w5tA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		5 / 5 TYR A 654
LYS A 660
PRO A 661
GLU A 695
TYR A 698
 None
None
None
IPH  A 901 (-3.6A)
IPH  A 901 ( 4.9A)
 0.76A 4w5tA-5weaA:
48.7		 4w5tA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		4 / 4 PHE A 587
VAL A 591
ALA A 620
PHE A 653
 None
 0.31A 4w5tA-5weaA:
48.7		 4w5tA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		5 / 6 ASP A 537
ALA A 543
LYS A 570
THR A 852
TYR A 857
 None
None
A  B   1 ( 4.0A)
None
None
 0.66A 4w5tA-5weaA:
48.7		 4w5tA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		4 / 6 ASP A 537
ALA A 543
LYS A 570
THR A 855
 None
None
A  B   1 ( 4.0A)
None
 1.19A 4w5tA-5weaA:
48.7		 4w5tA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		6 / 6 ARG A 688
CYH A 691
ILE A 692
GLN A 699
ILE A 702
ASP A 771
 None
 0.74A 4z4cA-5weaA:
58.5		 4z4cA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		5 / 6 LYS A 660
PRO A 661
LEU A 694
GLU A 695
TYR A 698
 None
None
IPH  A 901 (-3.9A)
IPH  A 901 (-3.6A)
IPH  A 901 ( 4.9A)
 0.80A 4z4cA-5weaA:
58.5		 4z4cA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		5 / 6 TYR A 654
PRO A 661
LEU A 694
GLU A 695
TYR A 698
 None
None
IPH  A 901 (-3.9A)
IPH  A 901 (-3.6A)
IPH  A 901 ( 4.9A)
 0.50A 4z4cA-5weaA:
58.5		 4z4cA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		5 / 5 PHE A 587
PRO A 590
VAL A 591
ALA A 620
PHE A 653
 None
 0.36A 4z4cA-5weaA:
58.5		 4z4cA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		5 / 6 ASP A 537
ALA A 543
LYS A 570
THR A 852
TYR A 857
 None
None
A  B   1 ( 4.0A)
None
None
 0.67A 4z4cA-5weaA:
58.5		 4z4cA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		4 / 6 ASP A 537
ALA A 543
LYS A 570
THR A 855
 None
None
A  B   1 ( 4.0A)
None
 1.22A 4z4cA-5weaA:
58.5		 4z4cA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		6 / 6 ARG A 688
CYH A 691
ILE A 692
GLN A 699
ILE A 702
ASP A 771
 None
 0.68A 4z4dA-5weaA:
58.8		 4z4dA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		4 / 5 LYS A 660
LEU A 694
GLU A 695
TYR A 698
 None
IPH  A 901 (-3.9A)
IPH  A 901 (-3.6A)
IPH  A 901 ( 4.9A)
 1.01A 4z4dA-5weaA:
58.8		 4z4dA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		4 / 5 TYR A 654
LEU A 694
GLU A 695
TYR A 698
 None
IPH  A 901 (-3.9A)
IPH  A 901 (-3.6A)
IPH  A 901 ( 4.9A)
 0.58A 4z4dA-5weaA:
58.8		 4z4dA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		5 / 5 PHE A 587
PRO A 590
VAL A 591
ALA A 620
PHE A 653
 None
 0.34A 4z4dA-5weaA:
58.8		 4z4dA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		4 / 5 ALA A 543
LYS A 570
THR A 852
TYR A 857
 None
A  B   1 ( 4.0A)
None
None
 0.51A 4z4dA-5weaA:
58.8		 4z4dA-5weaA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Z4E_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		7 / 7 ARG A 688
CYH A 691
ILE A 692
GLN A 699
PRO A 700
ILE A 702
ASP A 771
 None
 0.65A 4z4eA-5weaA:
58.8		 4z4eA-5weaA:
99.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Z4E_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		5 / 7 CYH A 691
ILE A 692
GLN A 699
PRO A 700
ILE A 664
 None
 1.42A 4z4eA-5weaA:
58.8		 4z4eA-5weaA:
99.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		4 / 4 TYR A 654
LYS A 660
GLU A 695
TYR A 698
 None
None
IPH  A 901 (-3.6A)
IPH  A 901 ( 4.9A)
 0.95A 4z4eA-5weaA:
58.8		 4z4eA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		5 / 5 PHE A 587
PRO A 590
VAL A 591
ALA A 620
PHE A 653
 None
 0.34A 4z4eA-5weaA:
58.8		 4z4eA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA907_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		4 / 5 ALA A 543
LYS A 570
THR A 852
TYR A 857
 None
A  B   1 ( 4.0A)
None
None
 0.53A 4z4eA-5weaA:
58.8		 4z4eA-5weaA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Z4F_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		6 / 7 LEU A 650
LYS A 660
PRO A 661
LEU A 694
GLU A 695
TYR A 698
 IPH  A 901 (-4.7A)
None
None
IPH  A 901 (-3.9A)
IPH  A 901 (-3.6A)
IPH  A 901 ( 4.9A)
 0.91A 4z4fA-5weaA:
57.4		 4z4fA-5weaA:
99.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Z4F_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		6 / 7 LEU A 650
TYR A 654
PRO A 661
LEU A 694
GLU A 695
TYR A 698
 IPH  A 901 (-4.7A)
None
None
IPH  A 901 (-3.9A)
IPH  A 901 (-3.6A)
IPH  A 901 ( 4.9A)
 0.65A 4z4fA-5weaA:
57.4		 4z4fA-5weaA:
99.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		4 / 4 VAL A 591
ALA A 620
PHE A 653
THR A 657
 None
 0.29A 4z4fA-5weaA:
57.4		 4z4fA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		5 / 6 ASP A 537
ALA A 543
LYS A 570
THR A 852
TYR A 857
 None
None
A  B   1 ( 4.0A)
None
None
 0.68A 4z4fA-5weaA:
57.4		 4z4fA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		4 / 6 ASP A 537
ALA A 543
LYS A 570
THR A 855
 None
None
A  B   1 ( 4.0A)
None
 1.16A 4z4fA-5weaA:
57.4		 4z4fA-5weaA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Z4G_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		7 / 7 ARG A 688
CYH A 691
ILE A 692
GLN A 699
PRO A 700
ILE A 702
ASP A 771
 None
 0.64A 4z4gA-5weaA:
58.7		 4z4gA-5weaA:
99.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Z4G_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		5 / 7 CYH A 691
ILE A 692
GLN A 699
PRO A 700
ILE A 664
 None
 1.46A 4z4gA-5weaA:
58.7		 4z4gA-5weaA:
99.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		5 / 6 LEU A 650
LYS A 660
PRO A 661
GLU A 695
TYR A 698
 IPH  A 901 (-4.7A)
None
None
IPH  A 901 (-3.6A)
IPH  A 901 ( 4.9A)
 0.92A 4z4gA-5weaA:
58.7		 4z4gA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		5 / 6 LEU A 650
TYR A 654
PRO A 661
GLU A 695
TYR A 698
 IPH  A 901 (-4.7A)
None
None
IPH  A 901 (-3.6A)
IPH  A 901 ( 4.9A)
 0.56A 4z4gA-5weaA:
58.7		 4z4gA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		4 / 4 PHE A 587
VAL A 591
ALA A 620
PHE A 653
 None
 0.24A 4z4gA-5weaA:
58.7		 4z4gA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		4 / 5 ASP A 537
ALA A 543
THR A 852
TYR A 857
 None
 0.68A 4z4gA-5weaA:
58.7		 4z4gA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		4 / 5 LYS A 660
LEU A 694
GLU A 695
TYR A 698
 None
IPH  A 901 (-3.9A)
IPH  A 901 (-3.6A)
IPH  A 901 ( 4.9A)
 0.91A 4z4hA-5weaA:
59.1		 4z4hA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		4 / 5 TYR A 654
LEU A 694
GLU A 695
TYR A 698
 None
IPH  A 901 (-3.9A)
IPH  A 901 (-3.6A)
IPH  A 901 ( 4.9A)
 0.55A 4z4hA-5weaA:
59.1		 4z4hA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		4 / 4 VAL A 591
ALA A 620
PHE A 653
THR A 657
 None
 0.25A 4z4hA-5weaA:
59.1		 4z4hA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		5 / 5 ARG A 688
GLN A 699
PRO A 700
ILE A 702
ASP A 771
 None
 0.66A 4z4hA-5weaA:
59.1		 4z4hA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		4 / 5 ASP A 537
ALA A 543
LYS A 570
THR A 855
 None
None
A  B   1 ( 4.0A)
None
 1.20A 4z4hA-5weaA:
59.1		 4z4hA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		4 / 5 ASP A 537
ALA A 543
LYS A 570
TYR A 857
 None
None
A  B   1 ( 4.0A)
None
 0.68A 4z4hA-5weaA:
59.1		 4z4hA-5weaA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Z4I_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		3 / 3 VAL A 591
ALA A 620
PHE A 653
 None
 0.29A 4z4iA-5weaA:
54.5		 4z4iA-5weaA:
99.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		5 / 6 ASP A 537
ALA A 543
LYS A 570
THR A 852
TYR A 857
 None
None
A  B   1 ( 4.0A)
None
None
 0.71A 4z4iA-5weaA:
54.5		 4z4iA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		4 / 6 ASP A 537
ALA A 543
LYS A 570
THR A 855
 None
None
A  B   1 ( 4.0A)
None
 1.17A 4z4iA-5weaA:
54.5		 4z4iA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_ADNA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		4 / 8 HIS A 807
SER A 798
SER A 763
ASP A 597
 None
A  B   5 ( 4.5A)
None
None
 1.07A 5a1iA-5weaA:
undetectable		 5a1iA-5weaA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_E_FK5E201_1
(FK506-BINDING
PROTEIN 1)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		5 / 11 VAL A 113
ILE A 132
ILE A  61
ILE A  74
PHE A  87
 None
 0.95A 5hw8E-5weaA:
undetectable		 5hw8E-5weaA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_F_FK5F201_1
(FK506-BINDING
PROTEIN 1)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		5 / 12 VAL A 113
ILE A 132
ILE A  61
ILE A  74
PHE A  87
 None
 0.85A 5hw8B-5weaA:
undetectable
5hw8F-5weaA:
undetectable
5hw8G-5weaA:
undetectable		 5hw8B-5weaA:
21.14
5hw8F-5weaA:
21.14
5hw8G-5weaA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		4 / 5 LYS A 660
LEU A 694
GLU A 695
TYR A 698
 None
IPH  A 901 (-3.9A)
IPH  A 901 (-3.6A)
IPH  A 901 ( 4.9A)
 0.71A 5js1A-5weaA:
59.0		 5js1A-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		4 / 5 TYR A 654
LEU A 694
GLU A 695
TYR A 698
 None
IPH  A 901 (-3.9A)
IPH  A 901 (-3.6A)
IPH  A 901 ( 4.9A)
 0.27A 5js1A-5weaA:
59.0		 5js1A-5weaA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JS1_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		3 / 3 VAL A 591
ALA A 620
PHE A 653
 None
 0.27A 5js1A-5weaA:
59.0		 5js1A-5weaA:
99.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		5 / 5 LEU A 650
TYR A 654
LYS A 660
LEU A 694
TYR A 698
 IPH  A 901 (-4.7A)
None
None
IPH  A 901 (-3.9A)
IPH  A 901 ( 4.9A)
 0.88A 5ki6A-5weaA:
60.5		 5ki6A-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		4 / 4 PHE A 587
VAL A 591
ALA A 620
PHE A 653
 None
 0.26A 5ki6A-5weaA:
60.5		 5ki6A-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		5 / 5 ARG A 688
CYH A 691
GLN A 699
PRO A 700
ILE A 702
 None
 0.65A 5ki6A-5weaA:
60.5		 5ki6A-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		4 / 5 CYH A 691
GLN A 699
PRO A 700
ILE A 664
 None
 1.39A 5ki6A-5weaA:
60.5		 5ki6A-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M24_A_9CRA501_1
(RETINOIC ACID
RECEPTOR GAMMA)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		5 / 12 ALA A 690
LEU A 650
ILE A 651
GLY A 616
ILE A 687
 None
IPH  A 901 (-4.7A)
IPH  A 901 ( 4.7A)
None
None
 1.10A 5m24A-5weaA:
undetectable		 5m24A-5weaA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		5 / 12 THR A 783
GLN A 780
ARG A  36
GLY A  35
LEU A 413
 None
 1.44A 5m50B-5weaA:
undetectable		 5m50B-5weaA:
12.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5T7B_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		6 / 6 PHE A 587
PRO A 590
VAL A 591
ALA A 620
PHE A 653
THR A 657
 None
 0.39A 5t7bA-5weaA:
60.0		 5t7bA-5weaA:
98.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5T7B_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		6 / 7 LEU A 650
LYS A 660
PRO A 661
LEU A 694
GLU A 695
TYR A 698
 IPH  A 901 (-4.7A)
None
None
IPH  A 901 (-3.9A)
IPH  A 901 (-3.6A)
IPH  A 901 ( 4.9A)
 0.90A 5t7bA-5weaA:
undetectable		 5t7bA-5weaA:
98.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5T7B_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		6 / 7 LEU A 650
TYR A 654
PRO A 661
LEU A 694
GLU A 695
TYR A 698
 IPH  A 901 (-4.7A)
None
None
IPH  A 901 (-3.9A)
IPH  A 901 (-3.6A)
IPH  A 901 ( 4.9A)
 0.65A 5t7bA-5weaA:
undetectable		 5t7bA-5weaA:
98.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		5 / 5 LEU A 650
TYR A 654
LYS A 660
LEU A 694
GLU A 695
 IPH  A 901 (-4.7A)
None
None
IPH  A 901 (-3.9A)
IPH  A 901 (-3.6A)
 0.00A 5weaA-5weaA:
68.4		 5weaA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		3 / 3 TYR A 857
ARG A 812
THR A 538
 None
A  B   1 ( 3.5A)
None
 0.90A 5z84J-5weaA:
undetectable		 5z84J-5weaA:
7.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_B_P2EB1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		4 / 5 PRO A 326
VAL A 284
GLY A 195
VAL A 230
 None
 1.08A 6ak3B-5weaA:
undetectable		 6ak3B-5weaA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		5 / 5 TYR A 654
LYS A 660
LEU A 694
GLU A 695
TYR A 698
 None
None
IPH  A 901 (-3.9A)
IPH  A 901 (-3.6A)
IPH  A 901 ( 4.9A)
 0.89A 6cbdA-5weaA:
57.8		 6cbdA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA902_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		4 / 4 VAL A 591
ALA A 620
PHE A 653
PHE A 659
 None
 0.27A 6cbdA-5weaA:
57.8		 6cbdA-5weaA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CBD_A_TRPA903_0
(PROTEIN ARGONAUTE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		6 / 6 ARG A 688
CYH A 691
ILE A 692
GLN A 699
ILE A 702
ASP A 771
 None
 0.61A 6cbdA-5weaA:
57.8		 6cbdA-5weaA:
99.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		4 / 8 HIS A 807
SER A 798
SER A 763
ASP A 597
 None
A  B   5 ( 4.5A)
None
None
 1.06A 6fbnB-5weaA:
undetectable		 6fbnB-5weaA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBO_A_ADNA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		4 / 8 HIS A 807
SER A 798
SER A 763
ASP A 597
 None
A  B   5 ( 4.5A)
None
None
 1.05A 6fboA-5weaA:
undetectable		 6fboA-5weaA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCB_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		4 / 8 HIS A 807
SER A 798
SER A 763
ASP A 597
 None
A  B   5 ( 4.5A)
None
None
 1.09A 6fcbA-5weaA:
undetectable		 6fcbA-5weaA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCD_A_ADNA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5wea PROTEIN ARGONAUTE-2
(Homo
sapiens) 		4 / 8 HIS A 807
SER A 798
SER A 763
ASP A 597
 None
A  B   5 ( 4.5A)
None
None
 1.07A 6fcdA-5weaA:
undetectable		 6fcdA-5weaA:
22.22