SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5weg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1321_0
(CHLOROPEROXIDASE)		 5weg UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Saccharum
hybrid
cultivar) 		4 / 5 LEU A 304
PHE A 350
VAL A 202
ALA A 343
 None
None
None
SO4  A 506 (-4.0A)
 1.14A 2cizA-5wegA:
undetectable		 2cizA-5wegA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F80_B_017B301_1
(POL POLYPROTEIN)		 5weg UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Saccharum
hybrid
cultivar) 		5 / 12 GLY A 200
ALA A 343
ASN A 302
VAL A 223
ILE A 225
 SO4  A 506 ( 4.9A)
SO4  A 506 (-4.0A)
SO4  A 506 ( 4.4A)
None
None
 0.89A 2f80A-5wegA:
undetectable		 2f80A-5wegA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_1
(ESTROGEN RECEPTOR)		 5weg UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Saccharum
hybrid
cultivar) 		5 / 12 MET A 322
THR A 341
LEU A 304
ILE A 311
PRO A 196
 None
 1.12A 2qxsB-5wegA:
undetectable		 2qxsB-5wegA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1357_1
(PROSTAGLANDIN
REDUCTASE 2)		 5weg UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Saccharum
hybrid
cultivar) 		4 / 6 TYR A 157
LEU A 140
ASN A  93
ASP A 229
 None
 1.36A 2w98A-5wegA:
undetectable
2w98B-5wegA:
1.9		 2w98A-5wegA:
13.21
2w98B-5wegA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_D_TOPD200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5weg UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Saccharum
hybrid
cultivar) 		5 / 9 LEU A 476
VAL A 431
ILE A 441
LEU A 443
PHE A 437
 None
 1.37A 3fl9D-5wegA:
undetectable		 3fl9D-5wegA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5weg UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Saccharum
hybrid
cultivar) 		4 / 4 LEU A 364
PRO A 365
LEU A 231
ARG A 112
 None
None
None
SO4  A 505 (-4.1A)
 1.48A 3hcoA-5wegA:
undetectable		 3hcoA-5wegA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 5weg UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Saccharum
hybrid
cultivar) 		5 / 12 ALA A 463
LEU A 443
SER A 419
ILE A 420
LEU A 373
 None
 1.16A 3k2hB-5wegA:
undetectable		 3k2hB-5wegA:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5weg UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Saccharum
hybrid
cultivar) 		4 / 6 GLU A 323
PHE A 349
ALA A 345
ALA A 346
 None
 1.13A 3ns1C-5wegA:
undetectable		 3ns1C-5wegA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_1
(HIV-1 PROTEASE)		 5weg UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Saccharum
hybrid
cultivar) 		5 / 10 LEU A  90
GLY A 200
ALA A 343
ILE A 347
VAL A 223
 None
SO4  A 506 ( 4.9A)
SO4  A 506 (-4.0A)
None
None
 0.94A 3oxwC-5wegA:
undetectable		 3oxwC-5wegA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_1
(HIV-1 PROTEASE)		 5weg UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Saccharum
hybrid
cultivar) 		5 / 10 LEU A  90
GLY A 200
ALA A 343
VAL A 315
VAL A 223
 None
SO4  A 506 ( 4.9A)
SO4  A 506 (-4.0A)
None
None
 0.99A 3oxwC-5wegA:
undetectable		 3oxwC-5wegA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U88_A_CHDA611_0
(MENIN)		 5weg UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Saccharum
hybrid
cultivar) 		3 / 3 SER A 292
PHE A 296
LYS A 297
 None
 0.74A 3u88A-5wegA:
undetectable		 3u88A-5wegA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD4_C_AOQC4003_1
(CYTOCHROME B)		 5weg UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Saccharum
hybrid
cultivar) 		5 / 12 GLY A 355
VAL A  65
ILE A 356
LEU A 243
ILE A 237
 None
 1.08A 4pd4C-5wegA:
undetectable		 4pd4C-5wegA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_ADNA2414_1
(RNA-DIRECTED RNA
POLYMERASE L)		 5weg UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Saccharum
hybrid
cultivar) 		4 / 6 GLU A 249
PHE A 350
ARG A 273
PHE A 349
 None
 1.43A 4uciA-5wegA:
undetectable		 4uciA-5wegA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_ADNB2415_1
(RNA-DIRECTED RNA
POLYMERASE L)		 5weg UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Saccharum
hybrid
cultivar) 		4 / 7 GLU A 249
PHE A 350
ARG A 273
PHE A 349
 None
 1.44A 4uciB-5wegA:
undetectable		 4uciB-5wegA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5weg UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Saccharum
hybrid
cultivar) 		4 / 8 GLY A  94
THR A 150
HIS A 147
THR A 146
 None
 0.92A 5eevL-5wegA:
undetectable
5eevV-5wegA:
undetectable		 5eevL-5wegA:
undetectable
5eevV-5wegA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5weg UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Saccharum
hybrid
cultivar) 		4 / 8 GLY A  94
THR A 150
HIS A 147
THR A 146
 None
 0.92A 5eewL-5wegA:
undetectable
5eewV-5wegA:
undetectable		 5eewL-5wegA:
undetectable
5eewV-5wegA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5weg UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Saccharum
hybrid
cultivar) 		4 / 8 GLY A  94
THR A 150
HIS A 147
THR A 146
 None
 0.92A 5ef3L-5wegA:
undetectable
5ef3V-5wegA:
undetectable		 5ef3L-5wegA:
undetectable
5ef3V-5wegA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_A_1FLA1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 5weg UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Saccharum
hybrid
cultivar) 		4 / 8 THR A 369
LEU A 373
ILE A 401
LEU A 374
 None
 0.90A 5g48A-5wegA:
undetectable		 5g48A-5wegA:
13.38