SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wez'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5wez TIR CHAPERONE
(Escherichia
coli) 		5 / 12 LEU A  84
TYR A  83
ALA A  77
GLY A  80
LEU A  74
 None
 1.26A 3ou7A-5wezA:
undetectable		 3ou7A-5wezA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P68_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 5wez TIR CHAPERONE
TRANSLOCATED INTIMIN
RECEPTOR TIR
(Escherichia
coli) 		5 / 11 ILE A  39
PHE A  31
SER B  40
ILE A  16
ILE A 113
 None
 1.33A 4p68A-5wezA:
undetectable		 4p68A-5wezA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_2
(GLUCOCORTICOID
RECEPTOR)		 5wez TIR CHAPERONE
(Escherichia
coli) 		3 / 3 MET A  50
MET A 120
TYR A  83
 None
 1.10A 4p6xI-5wezA:
undetectable		 4p6xI-5wezA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKL_B_SAMB8009_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN,HISTONE H3.1
PEPTIDE,ZINC FINGER
DOMAIN-CONTAINING
PROTEIN)		 5wez TIR CHAPERONE
(Escherichia
coli) 		5 / 12 LEU A  97
GLY A  53
TYR A  37
PHE A  12
LEU A 109
 None
 1.35A 5kklB-5wezA:
undetectable		 5kklB-5wezA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUN_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 5wez TIR CHAPERONE
(Escherichia
coli) 		5 / 9 ILE A  51
LEU A  41
ILE A 113
ASN A 111
ALA A 104
 None
 0.89A 5nunA-5wezA:
undetectable		 5nunA-5wezA:
30.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_1
(CYTOCHROME P450 3A4)		 5wez TIR CHAPERONE
TRANSLOCATED INTIMIN
RECEPTOR TIR
(Escherichia
coli) 		5 / 12 LEU A 109
ILE A  21
PHE A  12
ALA A  13
ILE B  38
 None
 1.16A 5vc0A-5wezA:
undetectable		 5vc0A-5wezA:
9.28