SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wfb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_B_VIBB501_1
(THIAMIN
PYROPHOSPHOKINASE)		 5wfb AP-4 COMPLEX
ACCESSORY SUBUNIT
TEPSIN
(Homo
sapiens) 		4 / 7 GLN A  51
LEU A  79
SER A  43
SER A  46
 None
 1.11A 1ig3A-5wfbA:
undetectable
1ig3B-5wfbA:
undetectable		 1ig3A-5wfbA:
19.92
1ig3B-5wfbA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5wfb AP-4 COMPLEX
ACCESSORY SUBUNIT
TEPSIN
(Homo
sapiens) 		4 / 8 SER A  12
ARG A  16
PHE A  13
ASP A   9
 None
 1.33A 1p6kB-5wfbA:
undetectable		 1p6kB-5wfbA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_F_TFPF211_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5wfb AP-4 COMPLEX
ACCESSORY SUBUNIT
TEPSIN
(Homo
sapiens) 		4 / 7 LEU A  20
PHE A  13
LEU A  57
SER A  84
 None
 1.06A 1wrlE-5wfbA:
undetectable
1wrlF-5wfbA:
undetectable		 1wrlE-5wfbA:
17.56
1wrlF-5wfbA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5wfb AP-4 COMPLEX
ACCESSORY SUBUNIT
TEPSIN
(Homo
sapiens) 		4 / 8 SER A  12
ARG A  16
PHE A  13
ASP A   9
 None
 1.32A 1zzuB-5wfbA:
undetectable		 1zzuB-5wfbA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5wfb AP-4 COMPLEX
ACCESSORY SUBUNIT
TEPSIN
(Homo
sapiens) 		4 / 8 GLN A  51
ASP A   9
SER A  12
SER A  46
 None
 1.26A 2xz5C-5wfbA:
undetectable
2xz5D-5wfbA:
undetectable		 2xz5C-5wfbA:
21.08
2xz5D-5wfbA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_J_CHDJ103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5wfb AP-4 COMPLEX
ACCESSORY SUBUNIT
TEPSIN
(Homo
sapiens) 		5 / 11 LEU A  76
LEU A  79
LEU A  57
GLU A  55
LEU A  53
 None
 0.94A 4wg0J-5wfbA:
undetectable
4wg0K-5wfbA:
undetectable
4wg0L-5wfbA:
undetectable		 4wg0J-5wfbA:
7.14
4wg0K-5wfbA:
7.14
4wg0L-5wfbA:
7.14