SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wfc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q13_A_TESA501_1
(PROSTAGLANDIN-E2
9-REDUCTASE)		 5wfc HISTONE-LYSINE-N-MET
HYLTRANSFERASE EZH2,
POLYCOMB PROTEIN
SUZ12 CHIMERA
(Chaetomium
thermophilum) 		4 / 6 TYR B 809
TYR B 878
HIS B 307
PRO B 299
 A97  B8009 (-4.7A)
A97  B8009 (-4.9A)
A97  B8009 (-4.4A)
None
 1.40A 1q13A-5wfcB:
undetectable		 1q13A-5wfcB:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_1
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 5wfc HISTONE-LYSINE-N-MET
HYLTRANSFERASE EZH2,
POLYCOMB PROTEIN
SUZ12 CHIMERA
(Chaetomium
thermophilum) 		3 / 3 ARG B2627
ARG B2631
ILE B2614
 None
 0.77A 1uobA-5wfcB:
undetectable		 1uobA-5wfcB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2888_0
(AMINOMETHYLTRANSFERA
SE)		 5wfc HISTONE-LYSINE-N-MET
HYLTRANSFERASE EZH2,
POLYCOMB PROTEIN
SUZ12 CHIMERA
(Chaetomium
thermophilum) 		5 / 10 LEU B 388
LEU B 385
ILE B 390
GLU B 407
LEU B 398
 None
 1.19A 1wopA-5wfcB:
undetectable		 1wopA-5wfcB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DM6_A_IMNA1401_1
(NADP-DEPENDENT
LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE)		 5wfc HISTONE-LYSINE-N-MET
HYLTRANSFERASE EZH2,
POLYCOMB PROTEIN
SUZ12 CHIMERA
(Chaetomium
thermophilum) 		5 / 10 ILE B 824
ALA B 794
ILE B 908
PRO B 889
ILE B 887
 None
 1.37A 2dm6A-5wfcB:
undetectable
2dm6B-5wfcB:
undetectable		 2dm6A-5wfcB:
17.58
2dm6B-5wfcB:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_C_ACTC1120_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 5wfc HISTONE-LYSINE-N-MET
HYLTRANSFERASE EZH2,
POLYCOMB PROTEIN
SUZ12 CHIMERA
(Chaetomium
thermophilum) 		3 / 3 LYS B2566
TYR B 878
PRO B2563
 None
A97  B8009 (-4.9A)
None
 1.37A 2j9cC-5wfcB:
undetectable		 2j9cC-5wfcB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OD9_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 5wfc HISTONE-LYSINE-N-MET
HYLTRANSFERASE EZH2,
POLYCOMB PROTEIN
SUZ12 CHIMERA
(Chaetomium
thermophilum) 		3 / 3 PHE B2606
PHE B2632
PHE B2629
 None
 0.85A 2od9A-5wfcB:
undetectable		 2od9A-5wfcB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQG_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 5wfc HISTONE-LYSINE-N-MET
HYLTRANSFERASE EZH2,
POLYCOMB PROTEIN
SUZ12 CHIMERA
(Chaetomium
thermophilum) 		3 / 3 PHE B2606
PHE B2632
PHE B2629
 None
 0.85A 2qqgA-5wfcB:
undetectable		 2qqgA-5wfcB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_1
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 5wfc HISTONE-LYSINE-N-MET
HYLTRANSFERASE EZH2,
POLYCOMB PROTEIN
SUZ12 CHIMERA
(Chaetomium
thermophilum) 		3 / 3 GLN B 750
THR B 673
TRP B 655
 None
 1.15A 2rctA-5wfcB:
undetectable		 2rctA-5wfcB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_H_CPFH1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 5wfc HISTONE-LYSINE-N-MET
HYLTRANSFERASE EZH2,
POLYCOMB PROTEIN
SUZ12 CHIMERA
(Chaetomium
thermophilum) 		3 / 3 ARG B2646
GLU B2605
SER B 591
 None
 0.66A 2xctD-5wfcB:
undetectable		 2xctD-5wfcB:
6.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5wfc HISTONE-LYSINE-N-MET
HYLTRANSFERASE EZH2,
POLYCOMB PROTEIN
SUZ12 CHIMERA
(Chaetomium
thermophilum) 		3 / 3 SER B2621
ASP B 756
ASP B 770
 None
 0.73A 3iv6C-5wfcB:
undetectable		 3iv6C-5wfcB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_A_ACTA207_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 5wfc HISTONE-LYSINE-N-MET
HYLTRANSFERASE EZH2,
POLYCOMB PROTEIN
SUZ12 CHIMERA
(Chaetomium
thermophilum) 		4 / 7 LEU B 454
LYS B 453
ARG B 455
ALA B 369
 None
 1.23A 3mbgA-5wfcB:
undetectable
3mbgB-5wfcB:
undetectable		 3mbgA-5wfcB:
undetectable
3mbgB-5wfcB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_1
(ENDOTHIAPEPSIN)		 5wfc HISTONE-LYSINE-N-MET
HYLTRANSFERASE EZH2,
POLYCOMB PROTEIN
SUZ12 CHIMERA
(Chaetomium
thermophilum) 		5 / 10 ILE B2580
ILE B 510
ILE B 865
THR B 827
ILE B 891
 None
 1.08A 3prsA-5wfcB:
undetectable		 3prsA-5wfcB:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_A_SAMA6734_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 5wfc HISTONE-LYSINE-N-MET
HYLTRANSFERASE EZH2,
POLYCOMB PROTEIN
SUZ12 CHIMERA
(Chaetomium
thermophilum) 		5 / 12 GLY B 808
TYR B 809
ASN B 880
HIS B 881
TYR B 918
 A97  B8009 (-3.4A)
A97  B8009 (-4.7A)
A97  B8009 (-3.9A)
None
None
 0.62A 3qxyA-5wfcB:
5.5		 3qxyA-5wfcB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_B_SAMB480_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 5wfc HISTONE-LYSINE-N-MET
HYLTRANSFERASE EZH2,
POLYCOMB PROTEIN
SUZ12 CHIMERA
(Chaetomium
thermophilum) 		5 / 12 GLY B 808
TYR B 809
ASN B 880
HIS B 881
TYR B 918
 A97  B8009 (-3.4A)
A97  B8009 (-4.7A)
A97  B8009 (-3.9A)
None
None
 0.62A 3rc0B-5wfcB:
5.3		 3rc0B-5wfcB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC2_1
(CYTOCHROME P450 2D6)		 5wfc HISTONE-LYSINE-N-MET
HYLTRANSFERASE EZH2,
POLYCOMB PROTEIN
SUZ12 CHIMERA
(Chaetomium
thermophilum) 		5 / 10 LEU B2625
VAL B2662
LEU B2653
PHE B2606
PHE B2650
 None
 1.43A 3tbgC-5wfcB:
undetectable		 3tbgC-5wfcB:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5wfc HISTONE-LYSINE-N-MET
HYLTRANSFERASE EZH2,
POLYCOMB PROTEIN
SUZ12 CHIMERA
(Chaetomium
thermophilum) 		4 / 5 ILE B2669
VAL B2668
CYH B 570
HIS B 567
 None
None
ZN  B8008 (-2.2A)
None
 1.37A 4rzvA-5wfcB:
undetectable		 4rzvA-5wfcB:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5wfc HISTONE-LYSINE-N-MET
HYLTRANSFERASE EZH2,
POLYCOMB PROTEIN
SUZ12 CHIMERA
(Chaetomium
thermophilum) 		4 / 8 THR B 504
LEU B 532
THR B 604
THR B2656
 None
 0.73A 4z90F-5wfcB:
undetectable
4z90G-5wfcB:
undetectable
4z90H-5wfcB:
undetectable
4z90I-5wfcB:
undetectable
4z90J-5wfcB:
undetectable		 4z90F-5wfcB:
12.70
4z90G-5wfcB:
12.70
4z90H-5wfcB:
12.70
4z90I-5wfcB:
12.70
4z90J-5wfcB:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5wfc HISTONE-LYSINE-N-MET
HYLTRANSFERASE EZH2,
POLYCOMB PROTEIN
SUZ12 CHIMERA
(Chaetomium
thermophilum) 		4 / 8 THR B 604
THR B2656
THR B 504
LEU B 532
 None
 0.78A 4z90F-5wfcB:
undetectable
4z90G-5wfcB:
undetectable
4z90H-5wfcB:
undetectable
4z90I-5wfcB:
undetectable
4z90J-5wfcB:
undetectable		 4z90F-5wfcB:
12.70
4z90G-5wfcB:
12.70
4z90H-5wfcB:
12.70
4z90I-5wfcB:
12.70
4z90J-5wfcB:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5wfc HISTONE-LYSINE-N-MET
HYLTRANSFERASE EZH2,
POLYCOMB PROTEIN
SUZ12 CHIMERA
(Chaetomium
thermophilum) 		5 / 7 THR B 504
LEU B 532
THR B 604
LEU B 542
THR B2656
 None
 1.21A 4z91F-5wfcB:
undetectable
4z91G-5wfcB:
undetectable
4z91H-5wfcB:
undetectable
4z91I-5wfcB:
undetectable
4z91J-5wfcB:
undetectable		 4z91F-5wfcB:
12.70
4z91G-5wfcB:
12.70
4z91H-5wfcB:
12.70
4z91I-5wfcB:
12.70
4z91J-5wfcB:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5wfc HISTONE-LYSINE-N-MET
HYLTRANSFERASE EZH2,
POLYCOMB PROTEIN
SUZ12 CHIMERA
(Chaetomium
thermophilum) 		4 / 7 THR B 604
THR B2656
THR B 504
LEU B 532
 None
 0.79A 4z91F-5wfcB:
undetectable
4z91G-5wfcB:
undetectable
4z91H-5wfcB:
undetectable
4z91I-5wfcB:
undetectable
4z91J-5wfcB:
undetectable		 4z91F-5wfcB:
12.70
4z91G-5wfcB:
12.70
4z91H-5wfcB:
12.70
4z91I-5wfcB:
12.70
4z91J-5wfcB:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_C_WJZC304_0
(BETA-LACTAMASE NDM-1)		 5wfc HISTONE-LYSINE-N-MET
HYLTRANSFERASE EZH2,
POLYCOMB PROTEIN
SUZ12 CHIMERA
(Chaetomium
thermophilum) 		4 / 7 HIS B 687
CYH B 685
GLY B 696
ASN B 695
 ZN  B8004 (-3.2A)
ZN  B8006 ( 2.3A)
None
None
 1.21A 5a5zC-5wfcB:
undetectable		 5a5zC-5wfcB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5wfc HISTONE-LYSINE-N-MET
HYLTRANSFERASE EZH2,
POLYCOMB PROTEIN
SUZ12 CHIMERA
(Chaetomium
thermophilum) 		3 / 3 VAL B 199
LEU B 463
MET B 402
 None
 0.80A 5ikrA-5wfcB:
undetectable		 5ikrA-5wfcB:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JJ0_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5wfc HISTONE-LYSINE-N-MET
HYLTRANSFERASE EZH2,
POLYCOMB PROTEIN
SUZ12 CHIMERA
(Chaetomium
thermophilum) 		5 / 12 GLY B 808
ASN B 880
HIS B 881
TYR B 918
PHE B 922
 A97  B8009 (-3.4A)
A97  B8009 (-3.9A)
None
None
None
 1.40A 5jj0B-5wfcB:
11.9		 5jj0B-5wfcB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKL_B_SAMB8009_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN,HISTONE H3.1
PEPTIDE,ZINC FINGER
DOMAIN-CONTAINING
PROTEIN)		 5wfc HISTONE-LYSINE-N-MET
HYLTRANSFERASE EZH2,
POLYCOMB PROTEIN
SUZ12 CHIMERA
(Chaetomium
thermophilum) 		7 / 12 GLY B 808
TYR B 809
TYR B 878
ASN B 880
HIS B 881
TYR B 918
PHE B 922
 A97  B8009 (-3.4A)
A97  B8009 (-4.7A)
A97  B8009 (-4.9A)
A97  B8009 (-3.9A)
None
None
None
 1.41A 5kklB-5wfcB:
47.2		 5kklB-5wfcB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKL_B_SAMB8009_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN,HISTONE H3.1
PEPTIDE,ZINC FINGER
DOMAIN-CONTAINING
PROTEIN)		 5wfc HISTONE-LYSINE-N-MET
HYLTRANSFERASE EZH2,
POLYCOMB PROTEIN
SUZ12 CHIMERA
(Chaetomium
thermophilum) 		8 / 12 LEU B 804
CYH B 807
GLY B 808
TYR B 809
TYR B 878
ASN B 880
HIS B 881
TYR B 918
 None
None
A97  B8009 (-3.4A)
A97  B8009 (-4.7A)
A97  B8009 (-4.9A)
A97  B8009 (-3.9A)
None
None
 0.36A 5kklB-5wfcB:
47.2		 5kklB-5wfcB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUJ_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 5wfc HISTONE-LYSINE-N-MET
HYLTRANSFERASE EZH2,
POLYCOMB PROTEIN
SUZ12 CHIMERA
(Chaetomium
thermophilum) 		4 / 8 ALA B 210
VAL B 213
ILE B 462
VAL B 457
 None
 0.72A 5nujA-5wfcB:
undetectable		 5nujA-5wfcB:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TQR_B_SAMB8009_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2, POLYCOMB
PROTEIN SUZ12)		 5wfc HISTONE-LYSINE-N-MET
HYLTRANSFERASE EZH2,
POLYCOMB PROTEIN
SUZ12 CHIMERA
(Chaetomium
thermophilum) 		8 / 10 LEU B 804
CYH B 807
GLY B 808
TYR B 809
TYR B 878
ASN B 880
HIS B 881
TYR B 918
 None
None
A97  B8009 (-3.4A)
A97  B8009 (-4.7A)
A97  B8009 (-4.9A)
A97  B8009 (-3.9A)
None
None
 0.26A 5tqrB-5wfcB:
52.9		 5tqrB-5wfcB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 5wfc HISTONE-LYSINE-N-MET
HYLTRANSFERASE EZH2,
POLYCOMB PROTEIN
SUZ12 CHIMERA
(Chaetomium
thermophilum) 		4 / 7 TYR B 918
PHE B 922
ALA B 869
GLY B 873
 None
 1.09A 5uxdA-5wfcB:
undetectable		 5uxdA-5wfcB:
14.95