SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wfi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_F_TFPF211_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5wfi -
(-) 		4 / 7 LEU A1730
PHE A1744
PHE A1732
LEU A1778
 None
 0.84A 1wrlE-5wfiA:
1.6
1wrlF-5wfiA:
undetectable		 1wrlE-5wfiA:
undetectable
1wrlF-5wfiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_2
(ADENOSINE KINASE)		 5wfi -
(-) 		4 / 4 ALA A1674
VAL A1620
PHE A1679
THR A1616
 None
 1.37A 2pkkA-5wfiA:
undetectable		 2pkkA-5wfiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		 5wfi -
(-) 		4 / 5 GLY A1644
ASP A1643
ARG A1751
GLN A1663
 GOL  A2001 (-3.5A)
None
GOL  A2001 ( 4.7A)
GOL  A2002 (-3.8A)
 1.47A 3qx3A-5wfiA:
undetectable		 3qx3A-5wfiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_D_EVPD1_1
(DNA TOPOISOMERASE
2-BETA)		 5wfi -
(-) 		4 / 5 GLY A1644
ASP A1643
ARG A1751
GLN A1663
 GOL  A2001 (-3.5A)
None
GOL  A2001 ( 4.7A)
GOL  A2002 (-3.8A)
 1.45A 3qx3B-5wfiA:
undetectable		 3qx3B-5wfiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_A_ECNA403_1
(FLAVOHEMOGLOBIN)		 5wfi -
(-) 		5 / 12 GLN A1726
LEU A1728
VAL A1777
LEU A1778
ILE A1771
 None
 1.09A 4g1bA-5wfiA:
undetectable		 4g1bA-5wfiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_A_ADNA501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 5wfi -
(-) 		3 / 3 PRO A1857
LEU A1856
HIS A1876
 None
 0.65A 4pevA-5wfiA:
undetectable		 4pevA-5wfiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_1
(ADENOSYLHOMOCYSTEINA
SE)		 5wfi -
(-) 		3 / 3 LEU A1637
GLN A1663
LYS A1610
 None
GOL  A2002 (-3.8A)
None
 0.95A 6exiB-5wfiA:
undetectable		 6exiB-5wfiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_0
(ADENOSYLHOMOCYSTEINA
SE)		 5wfi -
(-) 		3 / 3 LEU A1637
GLN A1663
LYS A1610
 None
GOL  A2002 (-3.8A)
None
 0.95A 6exiA-5wfiA:
undetectable		 6exiA-5wfiA:
undetectable