SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wgg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_0
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 5wgg RADICAL SAM DOMAIN
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 12 PHE A 183
LEU A  98
TYR A 169
GLY A 130
ILE A 134
 None
 1.12A 1kglA-5wggA:
undetectable		 1kglA-5wggA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_A_SAMA1501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 5wgg RADICAL SAM DOMAIN
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 7 TYR A 110
GLU A 155
THR A 186
SER A 210
 SAM  A 504 (-4.8A)
SAM  A 504 (-3.7A)
SAM  A 504 (-4.2A)
SAM  A 504 (-2.5A)
 0.40A 1tv8A-5wggA:
17.6		 1tv8A-5wggA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_A_URFA999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 5wgg RADICAL SAM DOMAIN
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 5 ALA A  61
TYR A  53
ILE A  33
ASP A  28
 None
None
None
CA  A 505 (-2.3A)
 1.22A 1upfA-5wggA:
undetectable		 1upfA-5wggA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_D_IMND476_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 5wgg CTEA
RADICAL SAM DOMAIN
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 12 CYH A 441
ILE A  14
VAL A  23
ILE A 329
LEU B   7
 None
 1.09A 1z9hD-5wggA:
undetectable		 1z9hD-5wggA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_0
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 5wgg RADICAL SAM DOMAIN
PROTEIN
CTEA
(Ruminiclostridiu
m
thermocellum;
Ruminiclostridiu
m
thermocellum) 		5 / 12 ALA A 447
ILE A 445
ASN B   8
ILE B   6
ALA A  22
 None
 1.21A 2ejtA-5wggA:
undetectable		 2ejtA-5wggA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_A_SAMA501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 5wgg RADICAL SAM DOMAIN
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 8 TYR A 110
CYH A 111
GLU A 155
THR A 186
SER A 210
 SAM  A 504 (-4.8A)
SF4  A 502 ( 2.4A)
SAM  A 504 (-3.7A)
SAM  A 504 (-4.2A)
SAM  A 504 (-2.5A)
 0.44A 2fb2A-5wggA:
17.8		 2fb2A-5wggA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_A_SAMA501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 5wgg RADICAL SAM DOMAIN
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 8 TYR A 110
CYH A 111
THR A 186
GLU A 155
 SAM  A 504 (-4.8A)
SF4  A 502 ( 2.4A)
SAM  A 504 (-4.2A)
SAM  A 504 (-3.7A)
 1.05A 2fb2A-5wggA:
17.8		 2fb2A-5wggA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_B_SAMB501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 5wgg RADICAL SAM DOMAIN
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 7 TYR A 110
GLU A 155
THR A 186
SER A 210
 SAM  A 504 (-4.8A)
SAM  A 504 (-3.7A)
SAM  A 504 (-4.2A)
SAM  A 504 (-2.5A)
 0.39A 2fb2B-5wggA:
17.7		 2fb2B-5wggA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA801_1
(PROSTAGLANDIN
REDUCTASE 1)		 5wgg RADICAL SAM DOMAIN
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 8 VAL A 252
TYR A 250
TYR A 312
VAL A 267
 None
 1.02A 2y05A-5wggA:
undetectable
2y05B-5wggA:
undetectable		 2y05A-5wggA:
21.82
2y05B-5wggA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1002_1
(HEMOLYTIC LECTIN
CEL-III)		 5wgg RADICAL SAM DOMAIN
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		3 / 3 ASP A  17
GLU A  69
GLY A  72
 None
 0.67A 3w9tA-5wggA:
undetectable		 3w9tA-5wggA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K36_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 5wgg RADICAL SAM DOMAIN
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 12 TYR A 110
GLU A 155
ASN A 188
SER A 210
ARG A 222
 SAM  A 504 (-4.8A)
SAM  A 504 (-3.7A)
SF4  A 502 ( 4.3A)
SAM  A 504 (-2.5A)
SF4  A 502 ( 3.6A)
 0.18A 4k36A-5wggA:
31.0		 4k36A-5wggA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K36_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 5wgg RADICAL SAM DOMAIN
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 12 TYR A 110
CYH A 111
GLU A 155
ASN A 188
ARG A 222
 SAM  A 504 (-4.8A)
SF4  A 502 ( 2.4A)
SAM  A 504 (-3.7A)
SF4  A 502 ( 4.3A)
SF4  A 502 ( 3.6A)
 0.18A 4k36B-5wggA:
30.9		 4k36B-5wggA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K37_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 5wgg RADICAL SAM DOMAIN
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 11 TYR A 110
CYH A 111
GLU A 155
SER A 210
ARG A 222
 SAM  A 504 (-4.8A)
SF4  A 502 ( 2.4A)
SAM  A 504 (-3.7A)
SAM  A 504 (-2.5A)
SF4  A 502 ( 3.6A)
 0.19A 4k37A-5wggA:
31.1		 4k37A-5wggA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K37_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 5wgg RADICAL SAM DOMAIN
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 11 TYR A 110
GLU A 155
ASN A 188
SER A 210
ARG A 222
 SAM  A 504 (-4.8A)
SAM  A 504 (-3.7A)
SF4  A 502 ( 4.3A)
SAM  A 504 (-2.5A)
SF4  A 502 ( 3.6A)
 0.19A 4k37B-5wggA:
30.9		 4k37B-5wggA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K39_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 5wgg RADICAL SAM DOMAIN
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 12 TYR A 110
GLU A 155
ASN A 188
SER A 210
ARG A 222
 SAM  A 504 (-4.8A)
SAM  A 504 (-3.7A)
SF4  A 502 ( 4.3A)
SAM  A 504 (-2.5A)
SF4  A 502 ( 3.6A)
 0.21A 4k39A-5wggA:
31.1		 4k39A-5wggA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKN_B_KANB403_1
(L-LACTATE
DEHYDROGENASE A
CHAIN)		 5wgg RADICAL SAM DOMAIN
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 9 ASP A  27
VAL A  26
ALA A  61
ILE A  65
ILE A  33
 None
 0.96A 4oknB-5wggA:
3.1		 4oknB-5wggA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_E_ASCE1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 5wgg RADICAL SAM DOMAIN
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 7 HIS A  24
HIS A   5
ILE A   4
VAL A  18
 None
 0.93A 5kkzC-5wggA:
undetectable
5kkzE-5wggA:
undetectable		 5kkzC-5wggA:
19.65
5kkzE-5wggA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_K_ASCK1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 5wgg RADICAL SAM DOMAIN
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 7 HIS A   5
ILE A   4
VAL A  18
HIS A  24
 None
 0.93A 5kkzK-5wggA:
undetectable
5kkzQ-5wggA:
undetectable		 5kkzK-5wggA:
20.04
5kkzQ-5wggA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_A_BEZA507_0
(BETA-LACTAMASE VIM-2)		 5wgg RADICAL SAM DOMAIN
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		3 / 3 THR A 354
HIS A 102
ASN A 123
 None
 0.74A 5n4tA-5wggA:
undetectable		 5n4tA-5wggA:
18.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WGG_A_SAMA504_0
(RADICAL SAM DOMAIN
PROTEIN)		 5wgg RADICAL SAM DOMAIN
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		12 / 12 TYR A 110
CYH A 111
PHE A 152
PRO A 156
THR A 186
ASN A 188
ARG A 222
ARG A 253
THR A 255
VAL A 283
VAL A 284
GLN A 364
 SAM  A 504 (-4.8A)
SF4  A 502 ( 2.4A)
SAM  A 504 (-4.1A)
None
SAM  A 504 (-4.2A)
SF4  A 502 ( 4.3A)
SF4  A 502 ( 3.6A)
SAM  A 504 (-3.2A)
SAM  A 504 (-3.4A)
SAM  A 504 (-4.0A)
SAM  A 504 (-3.6A)
SAM  A 504 ( 4.1A)
 0.00A 5wggA-5wggA:
63.7		 5wggA-5wggA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WHY_A_SAMA504_0
(RADICAL SAM DOMAIN
PROTEIN)		 5wgg RADICAL SAM DOMAIN
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		11 / 11 TYR A 110
CYH A 111
PHE A 152
GLU A 155
THR A 186
SER A 210
ARG A 222
ARG A 253
THR A 255
VAL A 283
VAL A 284
 SAM  A 504 (-4.8A)
SF4  A 502 ( 2.4A)
SAM  A 504 (-4.1A)
SAM  A 504 (-3.7A)
SAM  A 504 (-4.2A)
SAM  A 504 (-2.5A)
SF4  A 502 ( 3.6A)
SAM  A 504 (-3.2A)
SAM  A 504 (-3.4A)
SAM  A 504 (-4.0A)
SAM  A 504 (-3.6A)
 0.55A 5whyA-5wggA:
54.8		 5whyA-5wggA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WHY_B_SAMB504_0
(RADICAL SAM DOMAIN
PROTEIN)		 5wgg RADICAL SAM DOMAIN
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		10 / 10 TYR A 110
PHE A 152
GLU A 155
THR A 186
SER A 210
ARG A 222
ARG A 253
THR A 255
VAL A 283
VAL A 284
 SAM  A 504 (-4.8A)
SAM  A 504 (-4.1A)
SAM  A 504 (-3.7A)
SAM  A 504 (-4.2A)
SAM  A 504 (-2.5A)
SF4  A 502 ( 3.6A)
SAM  A 504 (-3.2A)
SAM  A 504 (-3.4A)
SAM  A 504 (-4.0A)
SAM  A 504 (-3.6A)
 0.42A 5whyB-5wggA:
54.9		 5whyB-5wggA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 5wgg RADICAL SAM DOMAIN
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 10 SER A 289
GLY A 290
ARG A 294
LEU A 293
PHE A 322
 None
 1.37A 5zjiA-5wggA:
undetectable
5zjiJ-5wggA:
undetectable		 5zjiA-5wggA:
10.16
5zjiJ-5wggA:
7.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_A_SAMA505_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 5wgg RADICAL SAM DOMAIN
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		3 / 3 ILE A 337
ASN A 393
CYH A 400
 None
None
SF4  A 503 (-2.3A)
 0.73A 6bp4A-5wggA:
undetectable		 6bp4A-5wggA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		 5wgg RADICAL SAM DOMAIN
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 6 GLN A 386
ASN A 387
LEU A 381
PHE A 136
 None
 1.24A 6ekuA-5wggA:
undetectable		 6ekuA-5wggA:
19.64