SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wh8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 GLY A 294
ALA A 328
THR A 287
THR A 288
SER A 346
 None
 1.47A 1c9sA-5wh8A:
undetectable
1c9sK-5wh8A:
undetectable		 1c9sA-5wh8A:
undetectable
1c9sK-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_B_TRPB81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 SER A 346
GLY A 294
ALA A 328
THR A 287
THR A 288
 None
 1.45A 1c9sA-5wh8A:
undetectable
1c9sB-5wh8A:
undetectable		 1c9sA-5wh8A:
undetectable
1c9sB-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 SER A 346
GLY A 294
ALA A 328
THR A 287
THR A 288
 None
 1.49A 1c9sC-5wh8A:
undetectable
1c9sD-5wh8A:
undetectable		 1c9sC-5wh8A:
undetectable
1c9sD-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 SER A 346
GLY A 294
ALA A 328
THR A 287
THR A 288
 None
 1.48A 1c9sD-5wh8A:
undetectable
1c9sE-5wh8A:
undetectable		 1c9sD-5wh8A:
undetectable
1c9sE-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 SER A 346
GLY A 294
ALA A 328
THR A 287
THR A 288
 None
 1.47A 1c9sE-5wh8A:
undetectable
1c9sF-5wh8A:
undetectable		 1c9sE-5wh8A:
undetectable
1c9sF-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 SER A 346
GLY A 294
ALA A 328
THR A 287
THR A 288
 None
 1.48A 1c9sF-5wh8A:
undetectable
1c9sG-5wh8A:
undetectable		 1c9sF-5wh8A:
undetectable
1c9sG-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_I_TRPI81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 SER A 346
GLY A 294
ALA A 328
THR A 287
THR A 288
 None
 1.46A 1c9sH-5wh8A:
undetectable
1c9sI-5wh8A:
undetectable		 1c9sH-5wh8A:
undetectable
1c9sI-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 SER A 346
GLY A 294
ALA A 328
THR A 287
THR A 288
 None
 1.47A 1c9sJ-5wh8A:
undetectable
1c9sK-5wh8A:
undetectable		 1c9sJ-5wh8A:
undetectable
1c9sK-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 GLY A 294
ALA A 328
THR A 287
THR A 288
SER A 346
 None
 1.46A 1c9sL-5wh8A:
undetectable
1c9sM-5wh8A:
undetectable		 1c9sL-5wh8A:
undetectable
1c9sM-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_M_TRPM81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 GLY A 294
ALA A 328
THR A 287
THR A 288
SER A 346
 None
 1.47A 1c9sM-5wh8A:
undetectable
1c9sN-5wh8A:
undetectable		 1c9sM-5wh8A:
undetectable
1c9sN-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_O_TRPO81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 GLY A 294
ALA A 328
THR A 287
THR A 288
SER A 346
 None
 1.45A 1c9sO-5wh8A:
undetectable
1c9sP-5wh8A:
undetectable		 1c9sO-5wh8A:
undetectable
1c9sP-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_R_TRPR81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 GLY A 294
ALA A 328
THR A 287
THR A 288
SER A 346
 None
 1.46A 1c9sR-5wh8A:
undetectable
1c9sS-5wh8A:
undetectable		 1c9sR-5wh8A:
undetectable
1c9sS-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_S_TRPS81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 GLY A 294
ALA A 328
THR A 287
THR A 288
SER A 346
 None
 1.47A 1c9sS-5wh8A:
undetectable
1c9sT-5wh8A:
undetectable		 1c9sS-5wh8A:
undetectable
1c9sT-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 7 GLY A 294
ALA A 328
THR A 287
THR A 288
SER A 346
 None
 1.46A 1c9sT-5wh8A:
undetectable
1c9sU-5wh8A:
undetectable		 1c9sT-5wh8A:
undetectable
1c9sU-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 GLY A 294
ALA A 328
THR A 287
THR A 288
SER A 346
 None
 1.46A 1gtfA-5wh8A:
undetectable
1gtfK-5wh8A:
undetectable		 1gtfA-5wh8A:
undetectable
1gtfK-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_B_TRPB81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 SER A 346
GLY A 294
ALA A 328
THR A 287
THR A 288
 None
 1.47A 1gtfA-5wh8A:
undetectable
1gtfB-5wh8A:
undetectable		 1gtfA-5wh8A:
undetectable
1gtfB-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 SER A 346
GLY A 294
ALA A 328
THR A 287
THR A 288
 None
 1.48A 1gtfB-5wh8A:
undetectable
1gtfC-5wh8A:
undetectable		 1gtfB-5wh8A:
undetectable
1gtfC-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 SER A 346
GLY A 294
ALA A 328
THR A 287
THR A 288
 None
 1.45A 1gtfE-5wh8A:
undetectable
1gtfF-5wh8A:
undetectable		 1gtfE-5wh8A:
undetectable
1gtfF-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 SER A 346
GLY A 294
ALA A 328
THR A 287
THR A 288
 None
 1.47A 1gtfF-5wh8A:
undetectable
1gtfG-5wh8A:
undetectable		 1gtfF-5wh8A:
undetectable
1gtfG-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 SER A 346
GLY A 294
ALA A 328
THR A 287
THR A 288
 None
 1.49A 1gtfI-5wh8A:
undetectable
1gtfJ-5wh8A:
undetectable		 1gtfI-5wh8A:
undetectable
1gtfJ-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 7 GLY A 294
ALA A 328
THR A 287
THR A 288
SER A 346
 None
 1.48A 1gtfL-5wh8A:
undetectable
1gtfM-5wh8A:
undetectable		 1gtfL-5wh8A:
undetectable
1gtfM-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_M_TRPM81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 GLY A 294
ALA A 328
THR A 287
THR A 288
SER A 346
 None
 1.49A 1gtfM-5wh8A:
undetectable
1gtfN-5wh8A:
undetectable		 1gtfM-5wh8A:
undetectable
1gtfN-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 8 GLY A 294
ALA A 328
THR A 287
THR A 288
SER A 346
 None
 1.46A 1gtfN-5wh8A:
undetectable
1gtfO-5wh8A:
undetectable		 1gtfN-5wh8A:
undetectable
1gtfO-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_O_TRPO81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 GLY A 294
ALA A 328
THR A 287
THR A 288
SER A 346
 None
 1.47A 1gtfO-5wh8A:
undetectable
1gtfP-5wh8A:
undetectable		 1gtfO-5wh8A:
undetectable
1gtfP-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_H_TRPH81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 SER A 346
GLY A 294
ALA A 328
THR A 287
THR A 288
 None
 1.49A 1gtnG-5wh8A:
undetectable
1gtnH-5wh8A:
undetectable		 1gtnG-5wh8A:
undetectable
1gtnH-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 GLY A 292
THR A 287
THR A 288
SER A 346
ALA A 329
 EDO  A 411 ( 3.9A)
None
None
None
None
 1.44A 1gtnQ-5wh8A:
undetectable
1gtnR-5wh8A:
undetectable		 1gtnQ-5wh8A:
undetectable
1gtnR-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 10 ILE A 114
PHE A 175
ILE A 218
ILE A 153
THR A 116
 None
 1.25A 1j3jA-5wh8A:
undetectable		 1j3jA-5wh8A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_A_TRPA81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 GLY A 294
ALA A 328
THR A 287
THR A 288
SER A 346
 None
 1.45A 1utdA-5wh8A:
undetectable
1utdB-5wh8A:
undetectable		 1utdA-5wh8A:
undetectable
1utdB-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_C_TRPC81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 GLY A 294
ALA A 328
THR A 287
THR A 288
SER A 346
 None
 1.49A 1utdC-5wh8A:
undetectable
1utdD-5wh8A:
undetectable		 1utdC-5wh8A:
undetectable
1utdD-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_D_TRPD81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 GLY A 294
ALA A 328
THR A 287
THR A 288
SER A 346
 None
 1.48A 1utdD-5wh8A:
undetectable
1utdE-5wh8A:
undetectable		 1utdD-5wh8A:
undetectable
1utdE-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_G_TRPG81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 GLY A 294
ALA A 328
THR A 287
THR A 288
SER A 346
 None
 1.46A 1utdG-5wh8A:
undetectable
1utdH-5wh8A:
undetectable		 1utdG-5wh8A:
undetectable
1utdH-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_K_TRPK81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 SER A 346
GLY A 294
ALA A 328
THR A 287
THR A 288
 None
 1.46A 1utdA-5wh8A:
undetectable
1utdK-5wh8A:
undetectable		 1utdA-5wh8A:
undetectable
1utdK-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_N_TRPN81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 10 GLY A 294
ALA A 328
THR A 287
THR A 288
SER A 346
 None
 1.48A 1utdN-5wh8A:
undetectable
1utdO-5wh8A:
undetectable		 1utdN-5wh8A:
undetectable
1utdO-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BL9_A_CP6A1240_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 12 ILE A 114
PHE A 175
ILE A 218
ILE A 153
THR A 116
 None
 1.15A 2bl9A-5wh8A:
undetectable		 2bl9A-5wh8A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HJH_A_NCAA900_0
(NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		4 / 5 ILE A 173
PRO A 174
PHE A 175
ILE A 218
 None
 1.07A 2hjhA-5wh8A:
undetectable		 2hjhA-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_A_NBVA1503_1
(GLUCOSYLCERAMIDASE)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 12 ASN A 195
GLU A 196
HIS A 256
GLU A 284
TRP A 318
 None
EDO  A 411 ( 4.1A)
None
EDO  A 411 (-3.3A)
EDO  A 411 (-2.7A)
 0.57A 2v3dA-5wh8A:
17.5		 2v3dA-5wh8A:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		3 / 3 TYR A 258
GLU A 196
ASN A 159
 EDO  A 411 (-4.0A)
EDO  A 411 ( 4.1A)
None
 1.01A 2y7hC-5wh8A:
undetectable		 2y7hC-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		3 / 3 HIS A 366
GLU A  51
HIS A 369
 None
 0.86A 3ba0A-5wh8A:
undetectable		 3ba0A-5wh8A:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 10 ILE A 114
PHE A 175
ILE A 218
ILE A 153
THR A 116
 None
 1.19A 3qgtA-5wh8A:
undetectable		 3qgtA-5wh8A:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 10 ILE A 114
PHE A 175
ILE A 218
ILE A 153
THR A 116
 None
 1.27A 3um5A-5wh8A:
undetectable		 3um5A-5wh8A:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 10 ILE A 114
PHE A 175
ILE A 218
ILE A 153
THR A 116
 None
 1.28A 3um5B-5wh8A:
undetectable		 3um5B-5wh8A:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W2T_B_LF7B801_1
(DIPEPTIDYL PEPTIDASE
4)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 12 ARG A 111
GLU A 192
TYR A 258
ASN A 195
HIS A 156
 None
None
EDO  A 411 (-4.0A)
None
None
 1.47A 3w2tB-5wh8A:
undetectable		 3w2tB-5wh8A:
7.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1002_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		3 / 3 ASN A 198
TRP A 234
ASP A 201
 None
 1.30A 4a7tA-5wh8A:
undetectable
4a7tF-5wh8A:
undetectable		 4a7tA-5wh8A:
19.87
4a7tF-5wh8A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4APJ_A_ACTA1635_0
(ANGIOTENSIN-CONVERTI
NG ENZYME
BRADYKININ-POTENTIAT
ING PEPTIDE B)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		4 / 6 HIS A 256
GLU A 284
ASP A 154
SER A  82
 None
EDO  A 411 (-3.3A)
None
None
 1.06A 4apjA-5wh8A:
undetectable
4apjP-5wh8A:
undetectable		 4apjA-5wh8A:
undetectable
4apjP-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_0
(METHYLTRANSFERASE
WBDD)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 12 GLY A  80
PHE A 110
ILE A 109
VAL A 316
ILE A 152
 None
 1.12A 4aztA-5wh8A:
undetectable		 4aztA-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTP_A_ASCA802_0
(RRNA N-GLYCOSIDASE)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		4 / 5 TYR A 191
ILE A 193
ASN A 250
ILE A 215
 None
 1.06A 4jtpA-5wh8A:
undetectable		 4jtpA-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA601_1
(SERUM ALBUMIN)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 12 LEU A 158
ASN A 195
CYH A 194
TYR A 258
GLY A 230
 EDO  A 411 (-3.7A)
None
None
EDO  A 411 (-4.0A)
None
 1.26A 4ot2A-5wh8A:
undetectable		 4ot2A-5wh8A:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA304_1
(TYROSINASE)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		4 / 5 ASN A 195
HIS A 156
GLU A 192
THR A 283
 None
 1.41A 4p6sA-5wh8A:
undetectable		 4p6sA-5wh8A:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_1
(PROLINE--TRNA LIGASE)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		3 / 3 GLU A 196
THR A 261
HIS A 262
 EDO  A 411 ( 4.1A)
None
EDO  A 413 (-3.8A)
 0.87A 4q15B-5wh8A:
undetectable		 4q15B-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TZC_D_EF2D505_1
(PROTEIN CEREBLON)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		4 / 8 THR A 254
HIS A 156
TRP A 176
PHE A 175
 None
 1.13A 4tzcB-5wh8A:
undetectable
4tzcD-5wh8A:
undetectable		 4tzcB-5wh8A:
26.04
4tzcD-5wh8A:
26.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UAC_A_ACRA501_2
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		4 / 7 GLU A 325
SER A  82
GLU A 284
THR A 254
 EDO  A 412 (-2.7A)
None
EDO  A 411 (-3.3A)
None
 1.30A 4uacA-5wh8A:
undetectable		 4uacA-5wh8A:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA602_1
(SERUM ALBUMIN)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 12 LEU A 158
ASN A 195
CYH A 194
TYR A 258
GLY A 230
 EDO  A 411 (-3.7A)
None
None
EDO  A 411 (-4.0A)
None
 1.25A 4zbrA-5wh8A:
undetectable		 4zbrA-5wh8A:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 SER A 346
GLY A 294
ALA A 328
THR A 287
THR A 288
 None
 1.49A 5eeuB-5wh8A:
undetectable
5eeuC-5wh8A:
undetectable		 5eeuB-5wh8A:
undetectable
5eeuC-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 SER A 346
GLY A 294
ALA A 328
THR A 287
THR A 288
 None
 1.46A 5eeuC-5wh8A:
undetectable
5eeuD-5wh8A:
undetectable		 5eeuC-5wh8A:
undetectable
5eeuD-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 SER A 346
GLY A 294
ALA A 328
THR A 287
THR A 288
 None
 1.47A 5eeuE-5wh8A:
undetectable
5eeuF-5wh8A:
undetectable		 5eeuE-5wh8A:
undetectable
5eeuF-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 10 SER A 346
GLY A 294
ALA A 328
THR A 287
THR A 288
 None
 1.44A 5eeuG-5wh8A:
undetectable
5eeuH-5wh8A:
undetectable		 5eeuG-5wh8A:
undetectable
5eeuH-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 GLY A 294
ALA A 328
THR A 287
THR A 288
SER A 346
 None
 1.47A 5eeuA-5wh8A:
undetectable
5eeuK-5wh8A:
undetectable		 5eeuA-5wh8A:
undetectable
5eeuK-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 SER A 346
GLY A 294
ALA A 328
THR A 287
THR A 288
 None
 1.45A 5eeuL-5wh8A:
undetectable
5eeuV-5wh8A:
undetectable		 5eeuL-5wh8A:
undetectable
5eeuV-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_M_TRPM101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 GLY A 294
ALA A 328
THR A 287
THR A 288
SER A 346
 None
 1.48A 5eeuL-5wh8A:
undetectable
5eeuM-5wh8A:
undetectable		 5eeuL-5wh8A:
undetectable
5eeuM-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_N_TRPN101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 GLY A 294
ALA A 328
THR A 287
THR A 288
SER A 346
 None
 1.47A 5eeuM-5wh8A:
undetectable
5eeuN-5wh8A:
undetectable		 5eeuM-5wh8A:
undetectable
5eeuN-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 10 GLY A 294
ALA A 328
THR A 287
THR A 288
SER A 346
 None
 1.46A 5eeuN-5wh8A:
undetectable
5eeuO-5wh8A:
undetectable		 5eeuN-5wh8A:
undetectable
5eeuO-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 10 GLY A 294
ALA A 328
THR A 287
THR A 288
SER A 346
 None
 1.47A 5eeuR-5wh8A:
undetectable
5eeuS-5wh8A:
undetectable		 5eeuR-5wh8A:
undetectable
5eeuS-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 SER A 346
GLY A 294
ALA A 328
THR A 287
THR A 288
 None
 1.49A 5eevB-5wh8A:
undetectable
5eevC-5wh8A:
undetectable		 5eevB-5wh8A:
undetectable
5eevC-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 SER A 346
GLY A 294
ALA A 328
THR A 287
THR A 288
 None
 1.46A 5eevC-5wh8A:
undetectable
5eevD-5wh8A:
undetectable		 5eevC-5wh8A:
undetectable
5eevD-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 SER A 346
GLY A 294
ALA A 328
THR A 287
THR A 288
 None
 1.47A 5eevE-5wh8A:
undetectable
5eevF-5wh8A:
undetectable		 5eevE-5wh8A:
undetectable
5eevF-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 10 SER A 346
GLY A 294
ALA A 328
THR A 287
THR A 288
 None
 1.43A 5eevG-5wh8A:
undetectable
5eevH-5wh8A:
undetectable		 5eevG-5wh8A:
undetectable
5eevH-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 SER A 346
GLY A 294
ALA A 328
THR A 287
THR A 288
 None
 1.47A 5eevH-5wh8A:
undetectable
5eevI-5wh8A:
undetectable		 5eevH-5wh8A:
undetectable
5eevI-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 GLY A 294
ALA A 328
THR A 287
THR A 288
SER A 346
 None
 1.47A 5eevA-5wh8A:
undetectable
5eevK-5wh8A:
undetectable		 5eevA-5wh8A:
undetectable
5eevK-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_M_TRPM101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 GLY A 294
ALA A 328
THR A 287
THR A 288
SER A 346
 None
 1.48A 5eevL-5wh8A:
undetectable
5eevM-5wh8A:
undetectable		 5eevL-5wh8A:
undetectable
5eevM-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_N_TRPN101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 GLY A 294
ALA A 328
THR A 287
THR A 288
SER A 346
 None
 1.48A 5eevM-5wh8A:
undetectable
5eevN-5wh8A:
undetectable		 5eevM-5wh8A:
undetectable
5eevN-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 10 GLY A 294
ALA A 328
THR A 287
THR A 288
SER A 346
 None
 1.46A 5eevN-5wh8A:
undetectable
5eevO-5wh8A:
undetectable		 5eevN-5wh8A:
undetectable
5eevO-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 SER A 346
GLY A 294
ALA A 328
THR A 287
THR A 288
 None
 1.49A 5eewB-5wh8A:
undetectable
5eewC-5wh8A:
undetectable		 5eewB-5wh8A:
undetectable
5eewC-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 SER A 346
GLY A 294
ALA A 328
THR A 287
THR A 288
 None
 1.47A 5eewC-5wh8A:
undetectable
5eewD-5wh8A:
undetectable		 5eewC-5wh8A:
undetectable
5eewD-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 SER A 346
GLY A 294
ALA A 328
THR A 287
THR A 288
 None
 1.47A 5eewE-5wh8A:
undetectable
5eewF-5wh8A:
undetectable		 5eewE-5wh8A:
undetectable
5eewF-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 10 SER A 346
GLY A 294
ALA A 328
THR A 287
THR A 288
 None
 1.44A 5eewG-5wh8A:
undetectable
5eewH-5wh8A:
undetectable		 5eewG-5wh8A:
undetectable
5eewH-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 GLY A 294
ALA A 328
THR A 287
THR A 288
SER A 346
 None
 1.47A 5eewA-5wh8A:
undetectable
5eewK-5wh8A:
undetectable		 5eewA-5wh8A:
undetectable
5eewK-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_M_TRPM101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 GLY A 294
ALA A 328
THR A 287
THR A 288
SER A 346
 None
 1.48A 5eewL-5wh8A:
undetectable
5eewM-5wh8A:
undetectable		 5eewL-5wh8A:
undetectable
5eewM-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_N_TRPN101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 GLY A 294
ALA A 328
THR A 287
THR A 288
SER A 346
 None
 1.48A 5eewM-5wh8A:
undetectable
5eewN-5wh8A:
undetectable		 5eewM-5wh8A:
undetectable
5eewN-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 10 GLY A 294
ALA A 328
THR A 287
THR A 288
SER A 346
 None
 1.46A 5eewN-5wh8A:
undetectable
5eewO-5wh8A:
undetectable		 5eewN-5wh8A:
undetectable
5eewO-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 SER A 346
GLY A 294
ALA A 328
THR A 287
THR A 288
 None
 1.50A 5eexB-5wh8A:
undetectable
5eexC-5wh8A:
undetectable		 5eexB-5wh8A:
undetectable
5eexC-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 SER A 346
GLY A 294
ALA A 328
THR A 287
THR A 288
 None
 1.47A 5eexC-5wh8A:
undetectable
5eexD-5wh8A:
undetectable		 5eexC-5wh8A:
undetectable
5eexD-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 SER A 346
GLY A 294
ALA A 328
THR A 287
THR A 288
 None
 1.48A 5eexE-5wh8A:
undetectable
5eexF-5wh8A:
undetectable		 5eexE-5wh8A:
undetectable
5eexF-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 10 SER A 346
GLY A 294
ALA A 328
THR A 287
THR A 288
 None
 1.44A 5eexG-5wh8A:
undetectable
5eexH-5wh8A:
undetectable		 5eexG-5wh8A:
undetectable
5eexH-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 SER A 346
GLY A 294
ALA A 328
THR A 287
THR A 288
 None
 1.46A 5eexL-5wh8A:
undetectable
5eexV-5wh8A:
undetectable		 5eexL-5wh8A:
undetectable
5eexV-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_M_TRPM101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 GLY A 294
ALA A 328
THR A 287
THR A 288
SER A 346
 None
 1.48A 5eexL-5wh8A:
undetectable
5eexM-5wh8A:
undetectable		 5eexL-5wh8A:
undetectable
5eexM-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_N_TRPN101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 GLY A 294
ALA A 328
THR A 287
THR A 288
SER A 346
 None
 1.48A 5eexM-5wh8A:
undetectable
5eexN-5wh8A:
undetectable		 5eexM-5wh8A:
undetectable
5eexN-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 10 GLY A 294
ALA A 328
THR A 287
THR A 288
SER A 346
 None
 1.47A 5eexN-5wh8A:
undetectable
5eexO-5wh8A:
undetectable		 5eexN-5wh8A:
undetectable
5eexO-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 GLY A 294
ALA A 328
THR A 287
THR A 288
SER A 346
 None
 1.45A 5eexQ-5wh8A:
undetectable
5eexR-5wh8A:
undetectable		 5eexQ-5wh8A:
undetectable
5eexR-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 SER A 346
GLY A 294
ALA A 328
THR A 287
THR A 288
 None
 1.50A 5eeyB-5wh8A:
undetectable
5eeyC-5wh8A:
undetectable		 5eeyB-5wh8A:
undetectable
5eeyC-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 SER A 346
GLY A 294
ALA A 328
THR A 287
THR A 288
 None
 1.47A 5eeyC-5wh8A:
undetectable
5eeyD-5wh8A:
undetectable		 5eeyC-5wh8A:
undetectable
5eeyD-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 SER A 346
GLY A 294
ALA A 328
THR A 287
THR A 288
 None
 1.48A 5eeyE-5wh8A:
undetectable
5eeyF-5wh8A:
undetectable		 5eeyE-5wh8A:
undetectable
5eeyF-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 10 SER A 346
GLY A 294
ALA A 328
THR A 287
THR A 288
 None
 1.44A 5eeyG-5wh8A:
undetectable
5eeyH-5wh8A:
undetectable		 5eeyG-5wh8A:
undetectable
5eeyH-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 SER A 346
GLY A 294
ALA A 328
THR A 287
THR A 288
 None
 1.48A 5eeyH-5wh8A:
undetectable
5eeyI-5wh8A:
undetectable		 5eeyH-5wh8A:
undetectable
5eeyI-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 GLY A 294
ALA A 328
THR A 287
THR A 288
SER A 346
 None
 1.47A 5eeyA-5wh8A:
undetectable
5eeyK-5wh8A:
undetectable		 5eeyA-5wh8A:
undetectable
5eeyK-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 SER A 346
GLY A 294
ALA A 328
THR A 287
THR A 288
 None
 1.46A 5eeyL-5wh8A:
undetectable
5eeyV-5wh8A:
undetectable		 5eeyL-5wh8A:
undetectable
5eeyV-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_M_TRPM101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 GLY A 294
ALA A 328
THR A 287
THR A 288
SER A 346
 None
 1.48A 5eeyL-5wh8A:
undetectable
5eeyM-5wh8A:
undetectable		 5eeyL-5wh8A:
undetectable
5eeyM-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_N_TRPN101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 GLY A 294
ALA A 328
THR A 287
THR A 288
SER A 346
 None
 1.48A 5eeyM-5wh8A:
undetectable
5eeyN-5wh8A:
undetectable		 5eeyM-5wh8A:
undetectable
5eeyN-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 10 GLY A 294
ALA A 328
THR A 287
THR A 288
SER A 346
 None
 1.47A 5eeyN-5wh8A:
undetectable
5eeyO-5wh8A:
undetectable		 5eeyN-5wh8A:
undetectable
5eeyO-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 GLY A 294
ALA A 328
THR A 287
THR A 288
SER A 346
 None
 1.45A 5eeyQ-5wh8A:
undetectable
5eeyR-5wh8A:
undetectable		 5eeyQ-5wh8A:
undetectable
5eeyR-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 SER A 346
GLY A 294
ALA A 328
THR A 287
THR A 288
 None
 1.50A 5eezB-5wh8A:
undetectable
5eezC-5wh8A:
undetectable		 5eezB-5wh8A:
undetectable
5eezC-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 SER A 346
GLY A 294
ALA A 328
THR A 287
THR A 288
 None
 1.47A 5eezC-5wh8A:
undetectable
5eezD-5wh8A:
undetectable		 5eezC-5wh8A:
undetectable
5eezD-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 SER A 346
GLY A 294
ALA A 328
THR A 287
THR A 288
 None
 1.48A 5eezE-5wh8A:
undetectable
5eezF-5wh8A:
undetectable		 5eezE-5wh8A:
undetectable
5eezF-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 10 SER A 346
GLY A 294
ALA A 328
THR A 287
THR A 288
 None
 1.44A 5eezG-5wh8A:
undetectable
5eezH-5wh8A:
undetectable		 5eezG-5wh8A:
undetectable
5eezH-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 SER A 346
GLY A 294
ALA A 328
THR A 287
THR A 288
 None
 1.48A 5eezH-5wh8A:
undetectable
5eezI-5wh8A:
undetectable		 5eezH-5wh8A:
undetectable
5eezI-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 SER A 346
GLY A 294
ALA A 328
THR A 287
THR A 288
 None
 1.45A 5eezJ-5wh8A:
undetectable
5eezK-5wh8A:
undetectable		 5eezJ-5wh8A:
undetectable
5eezK-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 GLY A 294
ALA A 328
THR A 287
THR A 288
SER A 346
 None
 1.48A 5eezA-5wh8A:
undetectable
5eezK-5wh8A:
undetectable		 5eezA-5wh8A:
undetectable
5eezK-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 8 SER A 346
GLY A 294
ALA A 328
THR A 287
THR A 288
 None
 1.46A 5eezL-5wh8A:
undetectable
5eezV-5wh8A:
undetectable		 5eezL-5wh8A:
undetectable
5eezV-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_M_TRPM101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 GLY A 294
ALA A 328
THR A 287
THR A 288
SER A 346
 None
 1.48A 5eezL-5wh8A:
undetectable
5eezM-5wh8A:
undetectable		 5eezL-5wh8A:
undetectable
5eezM-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_N_TRPN101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 GLY A 294
ALA A 328
THR A 287
THR A 288
SER A 346
 None
 1.48A 5eezM-5wh8A:
undetectable
5eezN-5wh8A:
undetectable		 5eezM-5wh8A:
undetectable
5eezN-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 10 GLY A 294
ALA A 328
THR A 287
THR A 288
SER A 346
 None
 1.47A 5eezN-5wh8A:
undetectable
5eezO-5wh8A:
undetectable		 5eezN-5wh8A:
undetectable
5eezO-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 GLY A 294
ALA A 328
THR A 287
THR A 288
SER A 346
 None
 1.45A 5eezQ-5wh8A:
undetectable
5eezR-5wh8A:
undetectable		 5eezQ-5wh8A:
undetectable
5eezR-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 SER A 346
GLY A 294
ALA A 328
THR A 287
THR A 288
 None
 1.47A 5ef0C-5wh8A:
undetectable
5ef0D-5wh8A:
undetectable		 5ef0C-5wh8A:
undetectable
5ef0D-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 SER A 346
GLY A 294
ALA A 328
THR A 287
THR A 288
 None
 1.49A 5ef0E-5wh8A:
undetectable
5ef0F-5wh8A:
undetectable		 5ef0E-5wh8A:
undetectable
5ef0F-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 10 SER A 346
GLY A 294
ALA A 328
THR A 287
THR A 288
 None
 1.44A 5ef0G-5wh8A:
undetectable
5ef0H-5wh8A:
undetectable		 5ef0G-5wh8A:
undetectable
5ef0H-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 SER A 346
GLY A 294
ALA A 328
THR A 287
THR A 288
 None
 1.48A 5ef0H-5wh8A:
undetectable
5ef0I-5wh8A:
undetectable		 5ef0H-5wh8A:
undetectable
5ef0I-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 SER A 346
GLY A 294
ALA A 328
THR A 287
THR A 288
 None
 1.45A 5ef0J-5wh8A:
undetectable
5ef0K-5wh8A:
undetectable		 5ef0J-5wh8A:
undetectable
5ef0K-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 SER A 346
GLY A 294
ALA A 328
THR A 287
THR A 288
 None
 1.46A 5ef0L-5wh8A:
undetectable
5ef0V-5wh8A:
undetectable		 5ef0L-5wh8A:
undetectable
5ef0V-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_M_TRPM101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 GLY A 294
ALA A 328
THR A 287
THR A 288
SER A 346
 None
 1.48A 5ef0L-5wh8A:
undetectable
5ef0M-5wh8A:
undetectable		 5ef0L-5wh8A:
undetectable
5ef0M-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_N_TRPN101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 GLY A 294
ALA A 328
THR A 287
THR A 288
SER A 346
 None
 1.48A 5ef0M-5wh8A:
undetectable
5ef0N-5wh8A:
undetectable		 5ef0M-5wh8A:
undetectable
5ef0N-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 10 GLY A 294
ALA A 328
THR A 287
THR A 288
SER A 346
 None
 1.47A 5ef0N-5wh8A:
undetectable
5ef0O-5wh8A:
undetectable		 5ef0N-5wh8A:
undetectable
5ef0O-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 GLY A 294
ALA A 328
THR A 287
THR A 288
SER A 346
 None
 1.45A 5ef0Q-5wh8A:
undetectable
5ef0R-5wh8A:
undetectable		 5ef0Q-5wh8A:
undetectable
5ef0R-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 SER A 346
GLY A 294
ALA A 328
THR A 287
THR A 288
 None
 1.47A 5ef1C-5wh8A:
undetectable
5ef1D-5wh8A:
undetectable		 5ef1C-5wh8A:
undetectable
5ef1D-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 SER A 346
GLY A 294
ALA A 328
THR A 287
THR A 288
 None
 1.49A 5ef1E-5wh8A:
undetectable
5ef1F-5wh8A:
undetectable		 5ef1E-5wh8A:
undetectable
5ef1F-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 10 SER A 346
GLY A 294
ALA A 328
THR A 287
THR A 288
 None
 1.44A 5ef1G-5wh8A:
undetectable
5ef1H-5wh8A:
undetectable		 5ef1G-5wh8A:
undetectable
5ef1H-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 SER A 346
GLY A 294
ALA A 328
THR A 287
THR A 288
 None
 1.48A 5ef1H-5wh8A:
undetectable
5ef1I-5wh8A:
undetectable		 5ef1H-5wh8A:
undetectable
5ef1I-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 SER A 346
GLY A 294
ALA A 328
THR A 287
THR A 288
 None
 1.45A 5ef1J-5wh8A:
undetectable
5ef1K-5wh8A:
undetectable		 5ef1J-5wh8A:
undetectable
5ef1K-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 GLY A 294
ALA A 328
THR A 287
THR A 288
SER A 346
 None
 1.48A 5ef1A-5wh8A:
undetectable
5ef1K-5wh8A:
undetectable		 5ef1A-5wh8A:
undetectable
5ef1K-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 8 SER A 346
GLY A 294
ALA A 328
THR A 287
THR A 288
 None
 1.47A 5ef1L-5wh8A:
undetectable
5ef1V-5wh8A:
undetectable		 5ef1L-5wh8A:
undetectable
5ef1V-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_M_TRPM101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 GLY A 294
ALA A 328
THR A 287
THR A 288
SER A 346
 None
 1.49A 5ef1L-5wh8A:
undetectable
5ef1M-5wh8A:
undetectable		 5ef1L-5wh8A:
undetectable
5ef1M-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_N_TRPN101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 GLY A 294
ALA A 328
THR A 287
THR A 288
SER A 346
 None
 1.48A 5ef1M-5wh8A:
undetectable
5ef1N-5wh8A:
undetectable		 5ef1M-5wh8A:
undetectable
5ef1N-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 10 GLY A 294
ALA A 328
THR A 287
THR A 288
SER A 346
 None
 1.47A 5ef1N-5wh8A:
undetectable
5ef1O-5wh8A:
undetectable		 5ef1N-5wh8A:
undetectable
5ef1O-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 GLY A 294
ALA A 328
THR A 287
THR A 288
SER A 346
 None
 1.45A 5ef1Q-5wh8A:
undetectable
5ef1R-5wh8A:
undetectable		 5ef1Q-5wh8A:
undetectable
5ef1R-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 SER A 346
GLY A 294
ALA A 328
THR A 287
THR A 288
 None
 1.47A 5ef2C-5wh8A:
undetectable
5ef2D-5wh8A:
undetectable		 5ef2C-5wh8A:
undetectable
5ef2D-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 SER A 346
GLY A 294
ALA A 328
THR A 287
THR A 288
 None
 1.49A 5ef2E-5wh8A:
undetectable
5ef2F-5wh8A:
undetectable		 5ef2E-5wh8A:
undetectable
5ef2F-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 10 SER A 346
GLY A 294
ALA A 328
THR A 287
THR A 288
 None
 1.44A 5ef2G-5wh8A:
undetectable
5ef2H-5wh8A:
undetectable		 5ef2G-5wh8A:
undetectable
5ef2H-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 SER A 346
GLY A 294
ALA A 328
THR A 287
THR A 288
 None
 1.48A 5ef2H-5wh8A:
undetectable
5ef2I-5wh8A:
undetectable		 5ef2H-5wh8A:
undetectable
5ef2I-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 SER A 346
GLY A 294
ALA A 328
THR A 287
THR A 288
 None
 1.45A 5ef2J-5wh8A:
undetectable
5ef2K-5wh8A:
undetectable		 5ef2J-5wh8A:
undetectable
5ef2K-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 GLY A 294
ALA A 328
THR A 287
THR A 288
SER A 346
 None
 1.48A 5ef2A-5wh8A:
undetectable
5ef2K-5wh8A:
undetectable		 5ef2A-5wh8A:
undetectable
5ef2K-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 8 SER A 346
GLY A 294
ALA A 328
THR A 287
THR A 288
 None
 1.47A 5ef2L-5wh8A:
undetectable
5ef2V-5wh8A:
undetectable		 5ef2L-5wh8A:
undetectable
5ef2V-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_M_TRPM101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 GLY A 294
ALA A 328
THR A 287
THR A 288
SER A 346
 None
 1.49A 5ef2L-5wh8A:
undetectable
5ef2M-5wh8A:
undetectable		 5ef2L-5wh8A:
undetectable
5ef2M-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_N_TRPN101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 GLY A 294
ALA A 328
THR A 287
THR A 288
SER A 346
 None
 1.48A 5ef2M-5wh8A:
undetectable
5ef2N-5wh8A:
undetectable		 5ef2M-5wh8A:
undetectable
5ef2N-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 10 GLY A 294
ALA A 328
THR A 287
THR A 288
SER A 346
 None
 1.47A 5ef2N-5wh8A:
undetectable
5ef2O-5wh8A:
undetectable		 5ef2N-5wh8A:
undetectable
5ef2O-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 GLY A 294
ALA A 328
THR A 287
THR A 288
SER A 346
 None
 1.45A 5ef2Q-5wh8A:
undetectable
5ef2R-5wh8A:
undetectable		 5ef2Q-5wh8A:
undetectable
5ef2R-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 SER A 346
GLY A 294
ALA A 328
THR A 287
THR A 288
 None
 1.47A 5ef3C-5wh8A:
undetectable
5ef3D-5wh8A:
undetectable		 5ef3C-5wh8A:
undetectable
5ef3D-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 SER A 346
GLY A 294
ALA A 328
THR A 287
THR A 288
 None
 1.49A 5ef3E-5wh8A:
undetectable
5ef3F-5wh8A:
undetectable		 5ef3E-5wh8A:
undetectable
5ef3F-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 10 SER A 346
GLY A 294
ALA A 328
THR A 287
THR A 288
 None
 1.45A 5ef3G-5wh8A:
undetectable
5ef3H-5wh8A:
undetectable		 5ef3G-5wh8A:
undetectable
5ef3H-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 SER A 346
GLY A 294
ALA A 328
THR A 287
THR A 288
 None
 1.48A 5ef3H-5wh8A:
undetectable
5ef3I-5wh8A:
undetectable		 5ef3H-5wh8A:
undetectable
5ef3I-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 SER A 346
GLY A 294
ALA A 328
THR A 287
THR A 288
 None
 1.45A 5ef3J-5wh8A:
undetectable
5ef3K-5wh8A:
undetectable		 5ef3J-5wh8A:
undetectable
5ef3K-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_M_TRPM101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 GLY A 294
ALA A 328
THR A 287
THR A 288
SER A 346
 None
 1.49A 5ef3L-5wh8A:
undetectable
5ef3M-5wh8A:
undetectable		 5ef3L-5wh8A:
undetectable
5ef3M-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_N_TRPN101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 GLY A 294
ALA A 328
THR A 287
THR A 288
SER A 346
 None
 1.48A 5ef3M-5wh8A:
undetectable
5ef3N-5wh8A:
undetectable		 5ef3M-5wh8A:
undetectable
5ef3N-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 10 GLY A 294
ALA A 328
THR A 287
THR A 288
SER A 346
 None
 1.47A 5ef3N-5wh8A:
undetectable
5ef3O-5wh8A:
undetectable		 5ef3N-5wh8A:
undetectable
5ef3O-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 9 GLY A 294
ALA A 328
THR A 287
THR A 288
SER A 346
 None
 1.45A 5ef3Q-5wh8A:
undetectable
5ef3R-5wh8A:
undetectable		 5ef3Q-5wh8A:
undetectable
5ef3R-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		4 / 8 THR A 116
TYR A 122
THR A 124
GLN A 126
 None
 1.38A 5tzoA-5wh8A:
undetectable		 5tzoA-5wh8A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		4 / 8 THR A 116
TYR A 122
THR A 124
GLN A 126
 None
 1.40A 5tzoB-5wh8A:
undetectable		 5tzoB-5wh8A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		4 / 8 THR A 116
TYR A 122
THR A 124
GLN A 126
 None
 1.38A 5tzoC-5wh8A:
undetectable		 5tzoC-5wh8A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_1
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		3 / 3 THR A 283
GLU A 192
HIS A 156
 None
 0.93A 5xioA-5wh8A:
undetectable		 5xioA-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		3 / 3 THR A 283
GLU A 192
HIS A 156
 None
 0.87A 5xiqB-5wh8A:
undetectable		 5xiqB-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		3 / 3 THR A 283
GLU A 192
HIS A 156
 None
 0.89A 5xiqD-5wh8A:
undetectable		 5xiqD-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_G_EF2G501_1
(PROTEIN CEREBLON)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		4 / 7 HIS A 156
TRP A 176
PHE A 175
THR A 254
 None
 1.10A 5yizG-5wh8A:
undetectable
5yizY-5wh8A:
undetectable		 5yizG-5wh8A:
23.46
5yizY-5wh8A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_T_EF2T501_1
(PROTEIN CEREBLON)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		4 / 7 THR A 254
HIS A 156
TRP A 176
PHE A 175
 None
 1.06A 5yizk-5wh8A:
undetectable
5yizt-5wh8A:
undetectable		 5yizk-5wh8A:
23.46
5yizt-5wh8A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_Y_EF2Y501_1
(PROTEIN CEREBLON)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		4 / 7 THR A 254
HIS A 156
TRP A 176
PHE A 175
 None
 1.11A 5yizG-5wh8A:
undetectable
5yizY-5wh8A:
undetectable		 5yizG-5wh8A:
23.46
5yizY-5wh8A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_G_6ELG501_0
(PROTEIN CEREBLON)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		4 / 8 HIS A 156
TRP A 176
PHE A 175
THR A 254
 None
 1.10A 5yj1G-5wh8A:
undetectable
5yj1Y-5wh8A:
undetectable		 5yj1G-5wh8A:
undetectable
5yj1Y-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_Y_6ELY501_0
(PROTEIN CEREBLON)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		4 / 7 THR A 254
HIS A 156
TRP A 176
PHE A 175
 None
 1.13A 5yj1G-5wh8A:
undetectable
5yj1Y-5wh8A:
undetectable		 5yj1G-5wh8A:
undetectable
5yj1Y-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B1E_B_LF7B801_1
(DIPEPTIDYL PEPTIDASE
4)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 12 ARG A 111
GLU A 192
TYR A 258
ASN A 195
HIS A 156
 None
None
EDO  A 411 (-4.0A)
None
None
 1.50A 6b1eB-5wh8A:
undetectable		 6b1eB-5wh8A:
7.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G6R_A_SAMA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		4 / 7 HIS A 183
ASP A 186
LYS A 182
ASP A 142
 None
 1.25A 6g6rA-5wh8A:
undetectable		 6g6rA-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MD4_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME
(uncultured
organism) 		5 / 12 GLY A  80
SER A  82
HIS A 156
LEU A 112
ILE A 149
 None
 1.36A 6md4A-5wh8A:
undetectable		 6md4A-5wh8A:
15.00