SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5whg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R5L_A_VIVA301_0
(PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN))		 5whg PROTEIN VMS1
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 282
ILE A 250
ILE A 324
VAL A 327
ILE A 353
 None
 1.01A 1r5lA-5whgA:
undetectable		 1r5lA-5whgA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA702_0
(FERROCHELATASE)		 5whg PROTEIN VMS1
(Saccharomyces
cerevisiae) 		4 / 7 ARG A 284
LEU A 320
VAL A 327
TRP A 331
 None
 1.27A 2hrcA-5whgA:
undetectable		 2hrcA-5whgA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_E_VD3E2001_1
(VITAMIN D
HYDROXYLASE)		 5whg PROTEIN VMS1
(Saccharomyces
cerevisiae) 		5 / 12 PRO A 377
ILE A 343
LEU A 320
ILE A 353
THR A 358
 None
 1.21A 3a50E-5whgA:
undetectable		 3a50E-5whgA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AMU_A_AG2A422_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 5whg PROTEIN VMS1
(Saccharomyces
cerevisiae) 		4 / 5 ASN A  99
VAL A  76
CYH A  77
ARG A 102
 None
None
ZN  A 501 (-2.3A)
None
 1.42A 3amuA-5whgA:
undetectable		 3amuA-5whgA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AU7_A_AG2A7011_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 5whg PROTEIN VMS1
(Saccharomyces
cerevisiae) 		4 / 4 ASN A  99
VAL A  76
CYH A  77
ARG A 102
 None
None
ZN  A 501 (-2.3A)
None
 1.39A 3au7A-5whgA:
0.0		 3au7A-5whgA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5whg PROTEIN VMS1
(Saccharomyces
cerevisiae) 		3 / 3 SER A 318
ASP A 350
ASP A 323
 None
 0.90A 3iv6C-5whgA:
undetectable		 3iv6C-5whgA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_2
(FIV PROTEASE)		 5whg PROTEIN VMS1
(Saccharomyces
cerevisiae) 		5 / 10 LEU A 328
ALA A 237
ILE A 235
VAL A 359
LEU A 335
 None
 1.21A 3ogpB-5whgA:
undetectable		 3ogpB-5whgA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_A_ASCA303_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 5whg PROTEIN VMS1
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 211
ILE A 206
PHE A  21
ASN A 227
 None
 1.28A 4o7gA-5whgA:
undetectable
4o7gB-5whgA:
undetectable		 4o7gA-5whgA:
18.46
4o7gB-5whgA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 5whg PROTEIN VMS1
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 210
TYR A 190
LEU A 389
GLU A 388
 None
 1.28A 5weaA-5whgA:
undetectable		 5weaA-5whgA:
17.69