SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5whm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 5whm ICLR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Brucella
abortus) 		4 / 7 VAL A 276
ILE A 117
ARG A 141
LEU A 272
 None
 0.96A 1iepB-5whmA:
undetectable		 1iepB-5whmA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I2Z_A_SALA1100_1
(SERUM ALBUMIN)		 5whm ICLR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Brucella
abortus) 		4 / 5 LEU A  28
LEU A  79
ILE A  65
ALA A  66
 None
 0.61A 2i2zA-5whmA:
undetectable		 2i2zA-5whmA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_1
(NS3 PROTEASE)		 5whm ICLR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Brucella
abortus) 		5 / 9 VAL A 247
HIS A 242
ALA A 237
VAL A 236
SER A 235
 None
None
None
None
ACY  A 301 (-3.4A)
 1.41A 6c2mA-5whmA:
undetectable		 6c2mA-5whmA:
14.79