SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5whz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5whz ANTI-HIV CODV-FAB
HEAVY CHAIN
(Homo
sapiens) 		5 / 10 THR H 101
PHE H 118
ALA H  99
VAL H  66
ILE H  72
 None
 1.07A 1claA-5whzH:
undetectable		 1claA-5whzH:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 5whz ANTI-HIV CODV-FAB
HEAVY CHAIN
ANTI-HIV CODV-FAB
LIGHT CHAIN
(Homo
sapiens;
Homo
sapiens) 		4 / 7 THR L 289
VAL H 332
GLY H 331
THR H 352
 None
 0.94A 2a1mA-5whzL:
undetectable		 2a1mA-5whzL:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2N27_A_4DYA205_1
(CALMODULIN)		 5whz ANTI-HIV CODV-FAB
HEAVY CHAIN
ANTI-HIV CODV-FAB
LIGHT CHAIN
(Homo
sapiens) 		5 / 11 THR H  93
ILE L 112
LEU H  20
MET H  85
VAL H 127
 None
 1.42A 2n27A-5whzH:
undetectable		 2n27A-5whzH:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 5whz ANTI-HIV CODV-FAB
HEAVY CHAIN
ANTI-HIV CODV-FAB
LIGHT CHAIN
(Homo
sapiens;
Homo
sapiens) 		3 / 3 ARG L 214
ASP L 209
ASP H  61
 None
 0.90A 3jb2A-5whzL:
undetectable		 3jb2A-5whzL:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZTV_A_ADNA1600_1
(NAD NUCLEOTIDASE)		 5whz ANTI-HIV CODV-FAB
HEAVY CHAIN
ANTI-HIV CODV-FAB
LIGHT CHAIN
(Homo
sapiens) 		5 / 9 GLY H 114
SER H 109
GLY H 110
TYR L 149
ASP H 106
 None
 1.12A 3ztvA-5whzH:
undetectable		 3ztvA-5whzH:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJQ_A_27RA401_1
(DNA POLYMERASE III
SUBUNIT BETA)		 5whz ANTI-HIV CODV-FAB
HEAVY CHAIN
ANTI-HIV CODV-FAB
LIGHT CHAIN
(Homo
sapiens) 		4 / 5 TYR H  95
THR H  93
PRO H  41
VAL L  89
 None
 0.96A 4mjqA-5whzH:
undetectable		 4mjqA-5whzH:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5whz ANTI-HIV CODV-FAB
HEAVY CHAIN
ANTI-HIV CODV-FAB
LIGHT CHAIN
(Homo
sapiens;
Homo
sapiens) 		3 / 3 SER H  65
ASP L 209
ASP L 143
 None
 0.86A 4mwzA-5whzH:
undetectable		 4mwzA-5whzH:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTS_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 5whz ANTI-HIV CODV-FAB
HEAVY CHAIN
ANTI-HIV CODV-FAB
LIGHT CHAIN
(Homo
sapiens;
Homo
sapiens) 		5 / 12 GLY H  42
GLY L  90
ILE L  22
SER L  21
ASP L 111
 None
 1.08A 4rtsA-5whzH:
undetectable		 4rtsA-5whzH:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_1
(ESTROGEN RECEPTOR)		 5whz ANTI-HIV CODV-FAB
HEAVY CHAIN
(Homo
sapiens) 		5 / 12 THR H 214
ALA H 215
LEU H 217
LEU H 170
LEU H 140
 None
 1.25A 4xi3D-5whzH:
undetectable		 4xi3D-5whzH:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_C_RAPC999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 5whz ANTI-HIV CODV-FAB
LIGHT CHAIN
(Homo
sapiens) 		4 / 8 SER L 151
GLY L 167
THR L 139
PHE L 218
 None
 0.96A 5flcB-5whzL:
undetectable		 5flcB-5whzL:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_G_RAPG999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 5whz ANTI-HIV CODV-FAB
LIGHT CHAIN
(Homo
sapiens) 		4 / 8 SER L 151
GLY L 167
THR L 139
PHE L 218
 None
 0.94A 5flcF-5whzL:
undetectable		 5flcF-5whzL:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_A_ACRA801_2
(GLUCOAMYLASE P)		 5whz ANTI-HIV CODV-FAB
HEAVY CHAIN
(Homo
sapiens) 		3 / 3 TRP H  47
GLU H  46
GLU H  64
 None
 0.74A 6fhwA-5whzH:
3.9		 6fhwA-5whzH:
12.02