SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wi5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_1
(HIV-1 PROTEASE)		 5wi5 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1
(Streptococcus
pneumoniae) 		5 / 10 ALA A 150
VAL A 114
ILE A 105
GLY A 103
ILE A 148
 None
 0.97A 1hsgA-5wi5A:
undetectable		 1hsgA-5wi5A:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_A_THAA1_1
(LIVER
CARBOXYLESTERASE I)		 5wi5 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1
(Streptococcus
pneumoniae) 		5 / 11 LEU A  35
GLY A 103
VAL A 139
LEU A 134
LEU A 179
 None
 1.13A 1mx1A-5wi5A:
undetectable		 1mx1A-5wi5A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_2
(PROTEASE)		 5wi5 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1
(Streptococcus
pneumoniae) 		5 / 11 ALA A 150
VAL A 114
ILE A 105
GLY A 103
ILE A 148
 None
 0.85A 1n49B-5wi5A:
undetectable		 1n49B-5wi5A:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_1
(PROTEASE)		 5wi5 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1
(Streptococcus
pneumoniae) 		5 / 11 ALA A 150
VAL A 114
ILE A 105
GLY A 103
ILE A 148
 None
 0.85A 1n49C-5wi5A:
undetectable		 1n49C-5wi5A:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		 5wi5 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1
(Streptococcus
pneumoniae) 		4 / 5 VAL A  52
ASN A  56
VAL A  46
ILE A  48
 None
 0.94A 1z2bC-5wi5A:
undetectable		 1z2bC-5wi5A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_B_IBPB2002_1
(SERUM ALBUMIN)		 5wi5 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1
(Streptococcus
pneumoniae) 		5 / 10 ALA A 245
ALA A 247
LEU A 293
LEU A 385
VAL A 386
 None
 1.05A 2bxgB-5wi5A:
undetectable		 2bxgB-5wi5A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 5wi5 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1
(Streptococcus
pneumoniae) 		5 / 10 ALA A 177
LEU A 202
VAL A 209
ILE A 195
ILE A 217
 None
 1.13A 3jw3A-5wi5A:
undetectable		 3jw3A-5wi5A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 5wi5 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1
(Streptococcus
pneumoniae) 		5 / 12 GLY A 346
VAL A 369
LEU A 380
THR A 315
ILE A 358
 None
 1.35A 3mnoA-5wi5A:
undetectable		 3mnoA-5wi5A:
21.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3V4T_A_ACTA502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5wi5 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1
(Streptococcus
pneumoniae) 		4 / 5 TYR A  89
VAL A  92
SER A 115
GLY A 118
 None
 0.27A 3v4tA-5wi5A:
60.9
3v4tD-5wi5A:
60.4		 3v4tA-5wi5A:
50.58
3v4tD-5wi5A:
50.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3V4T_H_ACTH503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5wi5 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1
(Streptococcus
pneumoniae) 		5 / 7 ALA A  97
ILE A  99
ARG A 125
HIS A 130
GLY A 168
 EPU  A 503 (-3.4A)
None
EPU  A 503 (-4.0A)
EPU  A 503 ( 4.9A)
EPU  A 503 (-3.3A)
 0.65A 3v4tH-5wi5A:
60.5		 3v4tH-5wi5A:
50.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3V4T_H_ACTH503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5wi5 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1
(Streptococcus
pneumoniae) 		5 / 7 ARG A  96
ALA A  97
ILE A  99
ARG A 125
HIS A 130
 None
EPU  A 503 (-3.4A)
None
EPU  A 503 (-4.0A)
EPU  A 503 ( 4.9A)
 0.79A 3v4tH-5wi5A:
60.5		 3v4tH-5wi5A:
50.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6D_A_SAMA1350_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 5wi5 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1
(Streptococcus
pneumoniae) 		5 / 12 PHE A 406
GLY A 384
ILE A   4
VAL A   6
ALA A 316
 None
 1.02A 4a6dA-5wi5A:
undetectable		 4a6dA-5wi5A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_0
(WBDD)		 5wi5 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1
(Streptococcus
pneumoniae) 		5 / 12 GLY A 384
ALA A 387
ILE A 381
VAL A   6
ILE A   4
 None
 0.99A 4ax8A-5wi5A:
2.6		 4ax8A-5wi5A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_0
(METHYLTRANSFERASE
WBDD)		 5wi5 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1
(Streptococcus
pneumoniae) 		5 / 12 GLY A 384
ALA A 387
ILE A 381
VAL A   6
ILE A   4
 None
 0.99A 4aztA-5wi5A:
undetectable		 4aztA-5wi5A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 5wi5 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1
(Streptococcus
pneumoniae) 		5 / 10 ALA A 177
ILE A 186
ALA A 136
ALA A 158
ILE A 160
 None
 1.06A 4lbgA-5wi5A:
undetectable		 4lbgA-5wi5A:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 5wi5 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1
(Streptococcus
pneumoniae) 		5 / 9 ALA A 177
ILE A 186
ALA A 136
ALA A 158
ILE A 160
 None
 0.96A 4lbgB-5wi5A:
undetectable		 4lbgB-5wi5A:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_A_FOLA301_1
(FOLATE RECEPTOR
ALPHA)		 5wi5 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1
(Streptococcus
pneumoniae) 		3 / 3 ASP A 252
TRP A 260
SER A  16
 None
 0.98A 4lrhA-5wi5A:
undetectable		 4lrhA-5wi5A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		 5wi5 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1
(Streptococcus
pneumoniae) 		4 / 6 GLU A 192
ASP A 309
GLU A 329
ARG A 125
 EPU  A 503 ( 4.9A)
EPU  A 503 (-2.8A)
None
EPU  A 503 (-4.0A)
 1.12A 4ntxA-5wi5A:
undetectable
4ntxC-5wi5A:
undetectable		 4ntxA-5wi5A:
20.62
4ntxC-5wi5A:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_1
(ANDROGEN RECEPTOR)		 5wi5 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1
(Streptococcus
pneumoniae) 		5 / 12 LEU A 102
GLY A 103
LEU A 155
MET A 137
ILE A 219
 None
 1.07A 4ok1A-5wi5A:
undetectable		 4ok1A-5wi5A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XNX_A_41XA707_1
(TRANSPORTER)		 5wi5 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1
(Streptococcus
pneumoniae) 		5 / 11 ASP A  10
ALA A 246
GLY A 414
VAL A  14
GLY A 251
 None
 1.26A 4xnxA-5wi5A:
undetectable		 4xnxA-5wi5A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5wi5 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1
(Streptococcus
pneumoniae) 		4 / 7 ALA A 376
VAL A 369
GLU A 341
HIS A 338
 None
 1.21A 5ecnA-5wi5A:
undetectable		 5ecnA-5wi5A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		 5wi5 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1
(Streptococcus
pneumoniae) 		4 / 8 HIS A 338
GLN A 311
LEU A 380
THR A 241
 None
 1.13A 5hs6A-5wi5A:
undetectable		 5hs6A-5wi5A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JDC_D_6JPD302_1
(PTERIDINE REDUCTASE)		 5wi5 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1
(Streptococcus
pneumoniae) 		5 / 11 HIS A 262
ASP A 235
VAL A 232
LEU A  29
PRO A  28
 None
 1.49A 5jdcA-5wi5A:
1.9
5jdcD-5wi5A:
undetectable		 5jdcA-5wi5A:
22.06
5jdcD-5wi5A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		 5wi5 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1
(Streptococcus
pneumoniae) 		4 / 6 ALA A  97
PRO A 117
VAL A  92
ASP A  51
 EPU  A 503 (-3.4A)
None
None
None
 0.93A 5umd2-5wi5A:
undetectable
5umdF-5wi5A:
undetectable		 5umd2-5wi5A:
12.61
5umdF-5wi5A:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VYH_A_FOLA409_0
(S PROTEIN)		 5wi5 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1
(Streptococcus
pneumoniae) 		5 / 10 PRO A 265
ALA A 239
GLY A  21
ILE A  19
ALA A 258
 None
 1.29A 5vyhA-5wi5A:
undetectable		 5vyhA-5wi5A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGG_A_SAMA504_0
(RADICAL SAM DOMAIN
PROTEIN)		 5wi5 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1
(Streptococcus
pneumoniae) 		5 / 12 PRO A  47
ARG A 375
ARG A 236
VAL A 167
GLN A 171
 None
None
None
EPU  A 503 (-3.8A)
EPU  A 503 ( 4.8A)
 1.39A 5wggA-5wi5A:
0.2		 5wggA-5wi5A:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_2
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 5wi5 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1
(Streptococcus
pneumoniae) 		4 / 4 VAL A  42
LEU A  43
LEU A  29
ASP A 197
 None
 1.47A 5xv7A-5wi5A:
undetectable		 5xv7A-5wi5A:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5wi5 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1
(Streptococcus
pneumoniae) 		4 / 8 HIS A 338
PHE A 314
PHE A 306
LEU A 270
 None
 1.08A 5y2tB-5wi5A:
undetectable		 5y2tB-5wi5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5wi5 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1
(Streptococcus
pneumoniae) 		5 / 10 ILE A  34
ILE A 195
ALA A 199
LEU A 202
ALA A 207
 None
 1.34A 5zjiB-5wi5A:
undetectable		 5zjiB-5wi5A:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_B_STRB502_1
(CYTOCHROME P450
CYP260A1)		 5wi5 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1
(Streptococcus
pneumoniae) 		4 / 6 LEU A 399
ALA A 378
LEU A  49
ASN A  24
 None
None
None
EPU  A 503 (-3.1A)
 0.96A 6f88B-5wi5A:
undetectable		 6f88B-5wi5A:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_A_NMYA303_0
(AAC(3)-IIIB PROTEIN)		 5wi5 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1
(Streptococcus
pneumoniae) 		5 / 10 ASP A 235
TYR A 403
THR A  18
THR A 241
GLY A 240
 None
 1.27A 6mb9A-5wi5A:
undetectable		 6mb9A-5wi5A:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_D_NMYD302_0
(AAC(3)-IIIB PROTEIN)		 5wi5 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1
(Streptococcus
pneumoniae) 		5 / 10 ASP A 235
TYR A 403
THR A  18
THR A 241
GLY A 240
 None
 1.33A 6mb9D-5wi5A:
undetectable		 6mb9D-5wi5A:
13.43