SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5win'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_A_CCSA417_0
(ESTROGEN RECEPTOR)		 5win -
(-) 		3 / 3 GLU A 627
LYS A 630
VAL A 629
 None
None
SKE  A 901 (-3.9A)
 0.95A 1l2iA-5winA:
undetectable		 1l2iA-5winA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG1_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 5win -
(-) 		3 / 3 TRP A 737
VAL A 719
PRO A 720
 None
 0.78A 1rg1A-5winA:
undetectable		 1rg1A-5winA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH0_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 5win -
(-) 		3 / 3 TRP A 737
VAL A 719
PRO A 720
 None
 0.78A 1rh0A-5winA:
undetectable		 1rh0A-5winA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_B_PAUB248_0
(TYPE III
PANTOTHENATE KINASE)		 5win -
(-) 		5 / 12 THR A 705
LEU A 730
THR A 734
VAL A 674
ILE A 670
 None
 1.05A 3bf1A-5winA:
undetectable
3bf1B-5winA:
undetectable		 3bf1A-5winA:
undetectable
3bf1B-5winA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 5win -
(-) 		3 / 3 ASN A 612
ASP A 699
ARG A 588
 None
 0.94A 3k13C-5winA:
undetectable		 3k13C-5winA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 5win -
(-) 		6 / 11 LYS A 581
VAL A 610
PHE A 628
GLY A 632
LEU A 680
SER A 698
 SKE  A 901 ( 4.7A)
SKE  A 901 ( 4.7A)
SKE  A 901 (-3.6A)
SKE  A 901 (-3.1A)
SKE  A 901 (-4.1A)
SKE  A 901 (-3.3A)
 0.70A 3miyA-5winA:
29.2		 3miyA-5winA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 5win -
(-) 		5 / 9 LYS A 581
PHE A 628
GLY A 632
LEU A 680
SER A 698
 SKE  A 901 ( 4.7A)
SKE  A 901 (-3.6A)
SKE  A 901 (-3.1A)
SKE  A 901 (-4.1A)
SKE  A 901 (-3.3A)
 0.72A 3miyB-5winA:
29.0		 3miyB-5winA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5win -
(-) 		6 / 11 LEU A 551
LYS A 581
VAL A 610
PHE A 628
GLY A 632
LEU A 680
 SKE  A 901 (-3.4A)
SKE  A 901 ( 4.7A)
SKE  A 901 ( 4.7A)
SKE  A 901 (-3.6A)
SKE  A 901 (-3.1A)
SKE  A 901 (-4.1A)
 0.68A 4agdA-5winA:
26.3		 4agdA-5winA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 5win -
(-) 		4 / 6 LEU A 638
LEU A 634
ILE A 695
THR A 742
 None
 0.95A 4do3B-5winA:
undetectable		 4do3B-5winA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVQ_A_ACTA903_0
(TYROSINE-PROTEIN
KINASE JAK2)		 5win -
(-) 		4 / 4 ASN A 673
CYH A 675
ARG A 715
TRP A 718
 None
 0.20A 4fvqA-5winA:
44.7		 4fvqA-5winA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5win -
(-) 		5 / 12 MET A 661
TRP A 718
ILE A 670
LEU A 730
THR A 742
 None
 1.04A 4pstA-5winA:
undetectable		 4pstA-5winA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5win -
(-) 		5 / 12 MET A 661
TRP A 718
ILE A 670
LEU A 730
THR A 742
 None
 1.02A 4pthA-5winA:
undetectable		 4pthA-5winA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RFQ_A_SAMA401_1
(HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG)		 5win -
(-) 		4 / 4 THR A 705
GLY A 672
ASP A 735
SER A 703
 None
 1.08A 4rfqA-5winA:
undetectable		 4rfqA-5winA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KLA_A_ACTA1505_0
(MATERNAL PROTEIN
PUMILIO)		 5win -
(-) 		3 / 3 HIS A 608
LYS A 696
PHE A 694
 None
 1.45A 5klaA-5winA:
undetectable		 5klaA-5winA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_0
(REGULATORY PROTEIN
TETR)		 5win -
(-) 		5 / 12 MET A 600
MET A 601
GLU A 665
LEU A 669
ILE A 670
 None
 1.03A 5vlmB-5winA:
undetectable		 5vlmB-5winA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 5win -
(-) 		5 / 12 MET A 661
TRP A 718
ILE A 670
LEU A 730
THR A 742
 None
 1.03A 7dfrA-5winA:
undetectable		 7dfrA-5winA:
undetectable