SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wix'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_D_ESTD352_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 5wix P-47 PROTEIN
(Clostridium
botulinum) 		4 / 6 VAL A 362
GLY A 363
LEU A 315
GLU A 281
 None
 0.97A 1fduD-5wixA:
undetectable		 1fduD-5wixA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWE_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 5wix P-47 PROTEIN
(Clostridium
botulinum) 		4 / 7 LEU A 211
VAL A 206
TYR A 187
TRP A 392
 None
 0.95A 1lweA-5wixA:
undetectable		 1lweA-5wixA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA472_1
(CYTOCHROME P450 51)		 5wix P-47 PROTEIN
(Clostridium
botulinum) 		4 / 6 MET A 227
VAL A 332
LEU A 378
PHE A 376
 None
 0.87A 1x8vA-5wixA:
undetectable		 1x8vA-5wixA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_B_J01B1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 5wix P-47 PROTEIN
(Clostridium
botulinum) 		5 / 12 LEU A 191
SER A 163
ILE A 165
LEU A 159
TYR A  10
 None
 1.24A 2japB-5wixA:
undetectable		 2japB-5wixA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_C_J01C1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 5wix P-47 PROTEIN
(Clostridium
botulinum) 		5 / 12 LEU A 191
SER A 163
ILE A 165
LEU A 159
TYR A  10
 None
 1.27A 2japC-5wixA:
undetectable		 2japC-5wixA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_D_J01D1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 5wix P-47 PROTEIN
(Clostridium
botulinum) 		5 / 12 LEU A 191
SER A 163
ILE A 165
LEU A 159
TYR A  10
 None
 1.25A 2japD-5wixA:
undetectable		 2japD-5wixA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)		 5wix P-47 PROTEIN
(Clostridium
botulinum) 		4 / 8 ILE A 282
PHE A 248
TYR A 269
LEU A 374
 None
 0.81A 2w98B-5wixA:
undetectable		 2w98B-5wixA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHX_B_PXLB313_1
(PYRIDOXAL KINASE)		 5wix P-47 PROTEIN
(Clostridium
botulinum) 		4 / 8 VAL A 303
THR A 306
TYR A 279
VAL A 362
 None
 1.06A 3fhxB-5wixA:
undetectable		 3fhxB-5wixA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		 5wix P-47 PROTEIN
(Clostridium
botulinum) 		5 / 10 LYS A  64
SER A 123
ILE A  85
SER A 126
GLY A 127
 None
 1.35A 3iluB-5wixA:
undetectable
3iluE-5wixA:
undetectable		 3iluB-5wixA:
20.40
3iluE-5wixA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_B_VIAB901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 5wix P-47 PROTEIN
(Clostridium
botulinum) 		5 / 11 ASN A 293
LEU A 295
VAL A 332
PHE A 376
THR A 321
 None
 1.31A 3jwqB-5wixA:
undetectable
3jwqC-5wixA:
undetectable		 3jwqB-5wixA:
20.97
3jwqC-5wixA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE201_1
(PROTEIN S100-A4)		 5wix P-47 PROTEIN
(Clostridium
botulinum) 		4 / 7 PHE A 135
GLY A 127
PHE A 137
PHE A  72
 None
 1.15A 3ko0D-5wixA:
undetectable
3ko0E-5wixA:
undetectable		 3ko0D-5wixA:
11.83
3ko0E-5wixA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA609_0
(GBAA_1210 PROTEIN)		 5wix P-47 PROTEIN
(Clostridium
botulinum) 		3 / 3 LYS A 104
VAL A 161
HIS A 102
 None
 0.80A 3tj7A-5wixA:
undetectable		 3tj7A-5wixA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 5wix P-47 PROTEIN
(Clostridium
botulinum) 		5 / 12 LEU A 230
LEU A 231
LEU A 405
ILE A 385
ILE A 411
 None
 1.13A 4j24A-5wixA:
undetectable		 4j24A-5wixA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 5wix P-47 PROTEIN
(Clostridium
botulinum) 		5 / 12 LEU A 230
LEU A 231
LEU A 405
ILE A 385
ILE A 411
 None
 1.09A 4j24B-5wixA:
undetectable		 4j24B-5wixA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSN_A_MMZA503_1
(FLAVIN-CONTAINING
MONOOXYGENASE)		 5wix P-47 PROTEIN
(Clostridium
botulinum) 		3 / 3 ASN A   2
SER A 209
SER A 208
 None
 0.75A 5gsnA-5wixA:
undetectable		 5gsnA-5wixA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_B_REAB503_1
(RETINOIC ACID
RECEPTOR BETA)		 5wix P-47 PROTEIN
(Clostridium
botulinum) 		5 / 12 LEU A 405
ILE A 404
ILE A 403
PHE A 382
LEU A 220
 None
 1.39A 5uanB-5wixA:
undetectable		 5uanB-5wixA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 5wix P-47 PROTEIN
(Clostridium
botulinum) 		4 / 4 VAL A   9
LEU A 202
ASN A   2
ASP A 207
 None
 1.18A 5vcyA-5wixA:
undetectable		 5vcyA-5wixA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FDY_U_DB8U302_1
(-)		 5wix P-47 PROTEIN
(Clostridium
botulinum) 		5 / 9 LEU A 289
MET A 227
PHE A 376
SER A 333
LEU A 378
 None
 1.32A 6fdyU-5wixA:
0.8		 6fdyU-5wixA:
22.22