SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wjc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_1
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 5wjc KINETOCHORE PROTEIN
MIS16
(Schizosaccharomy
ces
pombe) 		4 / 7 GLN A 215
THR A 214
SER A 216
GLN A 142
 None
 1.46A 1eiiA-5wjcA:
undetectable		 1eiiA-5wjcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPK_A_ACAA80_1
(PLASMINOGEN)		 5wjc KINETOCHORE PROTEIN
MIS16
(Schizosaccharomy
ces
pombe) 		4 / 6 ASP A  85
ASN A  84
TRP A  51
TYR A  88
 None
 1.44A 1hpkA-5wjcA:
undetectable		 1hpkA-5wjcA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXK_A_IMNA2001_1
(SERUM ALBUMIN)		 5wjc KINETOCHORE PROTEIN
MIS16
(Schizosaccharomy
ces
pombe) 		4 / 8 SER A 343
ARG A 317
LEU A 297
ASP A 303
 None
 0.98A 2bxkA-5wjcA:
undetectable		 2bxkA-5wjcA:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA701_0
(FERROCHELATASE)		 5wjc KINETOCHORE PROTEIN
MIS16
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU A 341
LEU A 331
ILE A 358
LEU A 260
VAL A 254
 None
 1.03A 2hrcA-5wjcA:
undetectable		 2hrcA-5wjcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1605_0
(FERROCHELATASE)		 5wjc KINETOCHORE PROTEIN
MIS16
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU A 341
LEU A 331
ILE A 358
LEU A 260
VAL A 254
 None
 1.12A 2hrcB-5wjcA:
undetectable		 2hrcB-5wjcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5wjc KINETOCHORE PROTEIN
MIS16
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU A 341
LEU A 331
ILE A 358
LEU A 260
VAL A 254
 None
 1.08A 2po7B-5wjcA:
undetectable		 2po7B-5wjcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCM_X_SAMX5452_0
(UNCHARACTERIZED
PROTEIN TM_1570)		 5wjc KINETOCHORE PROTEIN
MIS16
(Schizosaccharomy
ces
pombe) 		5 / 11 GLY A 201
GLY A 185
ILE A 284
ASN A 285
VAL A 241
 None
 0.93A 3dcmX-5wjcA:
undetectable		 3dcmX-5wjcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_2
(DIHYDROFOLATE
REDUCTASE)		 5wjc KINETOCHORE PROTEIN
MIS16
(Schizosaccharomy
ces
pombe) 		4 / 4 ILE A 146
PHE A 217
ILE A 158
THR A 162
 None
 1.12A 3ia4A-5wjcA:
undetectable		 3ia4A-5wjcA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEC_A_65BA561_0
(P66 REVERSE
TRANSCRIPTASE)		 5wjc KINETOCHORE PROTEIN
MIS16
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU A 198
VAL A 241
GLY A 201
LEU A 178
PRO A 227
 None
 1.28A 3mecA-5wjcA:
undetectable		 3mecA-5wjcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_0
(2'-O-METHYL
TRANSFERASE)		 5wjc KINETOCHORE PROTEIN
MIS16
(Schizosaccharomy
ces
pombe) 		5 / 12 ASN A 193
PRO A 192
LEU A 296
ASN A 290
ASP A 310
 None
 1.46A 3r24A-5wjcA:
undetectable		 3r24A-5wjcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6D_A_SAMA1350_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 5wjc KINETOCHORE PROTEIN
MIS16
(Schizosaccharomy
ces
pombe) 		6 / 12 TRP A 210
GLY A 185
GLY A 201
ILE A 237
VAL A 238
ALA A 156
 None
 1.35A 4a6dA-5wjcA:
undetectable		 4a6dA-5wjcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 5wjc KINETOCHORE PROTEIN
MIS16
(Schizosaccharomy
ces
pombe) 		6 / 12 TRP A 210
GLY A 185
GLY A 201
ILE A 237
VAL A 238
ALA A 156
 None
 1.35A 4a6eA-5wjcA:
undetectable		 4a6eA-5wjcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 5wjc KINETOCHORE PROTEIN
MIS16
(Schizosaccharomy
ces
pombe) 		3 / 3 TYR A 231
THR A 265
GLU A 270
 None
 0.74A 4df3A-5wjcA:
undetectable		 4df3A-5wjcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 5wjc KINETOCHORE PROTEIN
MIS16
(Schizosaccharomy
ces
pombe) 		3 / 3 TYR A 231
THR A 265
GLU A 270
 None
 0.74A 4df3B-5wjcA:
undetectable		 4df3B-5wjcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H1N_A_CGEA505_1
(CYTOCHROME P450 2B4)		 5wjc KINETOCHORE PROTEIN
MIS16
(Schizosaccharomy
ces
pombe) 		5 / 11 ILE A 146
LEU A  89
ALA A 156
ILE A 225
VAL A 212
 None
 1.15A 4h1nA-5wjcA:
undetectable		 4h1nA-5wjcA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OQR_A_2UOA502_1
(CYP105AS1)		 5wjc KINETOCHORE PROTEIN
MIS16
(Schizosaccharomy
ces
pombe) 		5 / 9 TRP A 210
VAL A 134
ILE A 225
VAL A 177
ALA A 176
 None
 1.08A 4oqrA-5wjcA:
undetectable		 4oqrA-5wjcA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		 5wjc KINETOCHORE PROTEIN
MIS16
(Schizosaccharomy
ces
pombe) 		4 / 8 GLY A 154
ILE A 225
SER A 226
GLY A 180
 None
 0.85A 5alcL-5wjcA:
undetectable		 5alcL-5wjcA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA605_1
(CHITINASE)		 5wjc KINETOCHORE PROTEIN
MIS16
(Schizosaccharomy
ces
pombe) 		3 / 3 TRP A 417
ILE A 340
SER A 334
 None
 0.99A 5gqbA-5wjcA:
undetectable		 5gqbA-5wjcA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M24_A_9CRA501_1
(RETINOIC ACID
RECEPTOR GAMMA)		 5wjc KINETOCHORE PROTEIN
MIS16
(Schizosaccharomy
ces
pombe) 		5 / 12 ALA A  92
LEU A  77
ILE A  76
GLY A 399
ILE A 122
 None
 1.12A 5m24A-5wjcA:
undetectable		 5m24A-5wjcA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UH6_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 5wjc KINETOCHORE PROTEIN
MIS16
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU A 407
GLN A 408
HIS A 378
ILE A 385
ARG A 349
 None
 1.50A 5uh6C-5wjcA:
1.7		 5uh6C-5wjcA:
6.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 5wjc KINETOCHORE PROTEIN
MIS16
(Schizosaccharomy
ces
pombe) 		5 / 10 SER A  53
GLY A  78
ILE A 122
ALA A  92
LEU A  75
 None
 1.31A 5zjiA-5wjcA:
undetectable
5zjiJ-5wjcA:
undetectable		 5zjiA-5wjcA:
24.72
5zjiJ-5wjcA:
20.99