SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wjp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SS4_A_ACTA411_0
(GLYOXALASE FAMILY
PROTEIN)		 5wjp CYCLOHEXADIENYL
DEHYDRATASE
(Candidatus
Pelagibacter
ubique) 		4 / 5 VAL A 112
THR A 111
GLN A 144
ILE A 136
 None
 1.27A 1ss4A-5wjpA:
undetectable		 1ss4A-5wjpA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5wjp CYCLOHEXADIENYL
DEHYDRATASE
(Candidatus
Pelagibacter
ubique) 		4 / 7 TRP A  33
TYR A 109
SER A 247
SER A 105
 None
 1.02A 2xz5A-5wjpA:
undetectable
2xz5B-5wjpA:
undetectable		 2xz5A-5wjpA:
22.68
2xz5B-5wjpA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_B_DESB800_1
(ESTROGEN RECEPTOR
ALPHA)		 5wjp CYCLOHEXADIENYL
DEHYDRATASE
(Candidatus
Pelagibacter
ubique) 		5 / 10 ALA A 185
GLU A 184
LEU A 195
LEU A 188
ARG A 165
 None
 1.45A 3erdB-5wjpA:
undetectable		 3erdB-5wjpA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5wjp CYCLOHEXADIENYL
DEHYDRATASE
(Candidatus
Pelagibacter
ubique) 		4 / 7 GLY A  28
THR A  29
ILE A  75
THR A 103
 None
 0.95A 4acaC-5wjpA:
undetectable		 4acaC-5wjpA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 5wjp CYCLOHEXADIENYL
DEHYDRATASE
(Candidatus
Pelagibacter
ubique) 		3 / 3 LYS A 228
ASN A 237
ASP A 104
 None
 0.71A 4o1eA-5wjpA:
undetectable		 4o1eA-5wjpA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMK_A_EF2A151_1
(CEREBLON ISOFORM 4)		 5wjp CYCLOHEXADIENYL
DEHYDRATASE
(Candidatus
Pelagibacter
ubique) 		4 / 8 ASN A 204
PRO A 205
PHE A 151
TRP A 126
 None
 1.49A 5amkA-5wjpA:
undetectable		 5amkA-5wjpA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_F_MTXF402_1
(THYMIDYLATE SYNTHASE)		 5wjp CYCLOHEXADIENYL
DEHYDRATASE
(Candidatus
Pelagibacter
ubique) 		5 / 12 PHE A 151
ILE A 179
LEU A 157
PHE A 152
VAL A 160
 None
 1.05A 5x66F-5wjpA:
undetectable		 5x66F-5wjpA:
21.57