SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wka'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_O_TRPO81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5wka BETA-GLUCOSIDASE
(metagenome) 		5 / 10 GLY A 213
HIS A 196
ALA A 203
THR A 158
ALA A 202
 None
 1.41A 1gtnO-5wkaA:
undetectable
1gtnP-5wkaA:
undetectable		 1gtnO-5wkaA:
undetectable
1gtnP-5wkaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5wka BETA-GLUCOSIDASE
(metagenome) 		5 / 9 GLY A 213
HIS A 196
ALA A 203
THR A 158
ALA A 202
 None
 1.47A 1gtnQ-5wkaA:
undetectable
1gtnR-5wkaA:
undetectable		 1gtnQ-5wkaA:
undetectable
1gtnR-5wkaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		 5wka BETA-GLUCOSIDASE
(metagenome) 		4 / 5 TYR A 292
LEU A 353
THR A 215
ARG A  73
 GOL  A 501 (-4.3A)
None
None
None
 1.22A 1i2wA-5wkaA:
undetectable		 1i2wA-5wkaA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		 5wka BETA-GLUCOSIDASE
(metagenome) 		4 / 5 TYR A 292
PRO A 294
LEU A 221
THR A 164
 GOL  A 501 (-4.3A)
None
None
None
 1.38A 1i2wA-5wkaA:
undetectable		 1i2wA-5wkaA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDU_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 5wka BETA-GLUCOSIDASE
(metagenome) 		5 / 11 LEU A 418
GLY A 455
PRO A 446
VAL A 435
ILE A 434
 None
 0.96A 1sduA-5wkaA:
undetectable		 1sduA-5wkaA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		 5wka BETA-GLUCOSIDASE
(metagenome) 		4 / 7 TYR A 392
HIS A 396
LEU A 349
TYR A 292
 None
None
None
GOL  A 501 (-4.3A)
 1.19A 1tuvA-5wkaA:
undetectable		 1tuvA-5wkaA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_A_SAMA1501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 5wka BETA-GLUCOSIDASE
(metagenome) 		4 / 7 TYR A 453
GLU A 369
THR A  12
VAL A  69
 None
GOL  A 501 (-3.4A)
None
None
 1.21A 1tv8A-5wkaA:
6.0		 1tv8A-5wkaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		 5wka BETA-GLUCOSIDASE
(metagenome) 		4 / 6 TYR A 292
GLY A 427
PHE A 426
SER A 429
 GOL  A 501 (-4.3A)
None
None
None
 1.36A 2a3cB-5wkaA:
8.1		 2a3cB-5wkaA:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 5wka BETA-GLUCOSIDASE
(metagenome) 		4 / 5 LEU A 418
PRO A 446
VAL A 435
ILE A 434
 None
 0.95A 2aoiB-5wkaA:
undetectable		 2aoiB-5wkaA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_B_SAMB501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 5wka BETA-GLUCOSIDASE
(metagenome) 		4 / 7 TYR A 453
GLU A 369
THR A  12
VAL A  69
 None
GOL  A 501 (-3.4A)
None
None
 1.17A 2fb2B-5wkaA:
3.8		 2fb2B-5wkaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 5wka BETA-GLUCOSIDASE
(metagenome) 		4 / 5 ALA A 372
ASP A 420
ASP A 438
ASP A 386
 None
 1.00A 2nyuB-5wkaA:
undetectable		 2nyuB-5wkaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCD_A_RAPA138_1
(OUTER MEMBRANE
PROTEIN MIP)		 5wka BETA-GLUCOSIDASE
(metagenome) 		5 / 11 ASP A  60
PHE A  96
GLN A  98
PRO A 113
TYR A  72
 None
 1.44A 2vcdA-5wkaA:
undetectable		 2vcdA-5wkaA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_A_FOLA401_0
(DIHYDROFOLATE
REDUCTASE)		 5wka BETA-GLUCOSIDASE
(metagenome) 		5 / 12 ILE A  17
ALA A  14
ARG A  99
PRO A 111
LEU A  64
 None
 1.06A 2w3bA-5wkaA:
undetectable		 2w3bA-5wkaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_2
(HIV-1 PROTEASE)		 5wka BETA-GLUCOSIDASE
(metagenome) 		5 / 9 LEU A 418
ILE A 390
PRO A 446
VAL A 435
ILE A 434
 None
 1.13A 3d1yB-5wkaA:
undetectable		 3d1yB-5wkaA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5wka BETA-GLUCOSIDASE
(metagenome) 		5 / 12 GLY A 213
THR A 157
SER A 282
ILE A 363
LEU A 287
 None
 1.29A 3iv6A-5wkaA:
undetectable		 3iv6A-5wkaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5wka BETA-GLUCOSIDASE
(metagenome) 		5 / 12 GLY A 213
THR A 157
SER A 282
ILE A 363
LEU A 287
 None
 1.27A 3iv6C-5wkaA:
undetectable		 3iv6C-5wkaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_H_SAMH226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5wka BETA-GLUCOSIDASE
(metagenome) 		5 / 12 LEU A 353
GLY A 288
GLY A 213
LEU A 249
ILE A 284
 None
 0.85A 3ku1H-5wkaA:
undetectable		 3ku1H-5wkaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_1
(PROTEASE)		 5wka BETA-GLUCOSIDASE
(metagenome) 		5 / 12 LEU A 418
GLY A   9
PRO A 446
VAL A 435
ILE A 434
 None
 1.03A 3nduC-5wkaA:
undetectable		 3nduC-5wkaA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5wka BETA-GLUCOSIDASE
(metagenome) 		3 / 3 TYR A  54
ASP A  52
ASP A  48
 None
 0.92A 3ou7B-5wkaA:
undetectable		 3ou7B-5wkaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_2
(PROTEASE)		 5wka BETA-GLUCOSIDASE
(metagenome) 		3 / 3 ARG A 444
LEU A  63
THR A  10
 None
 0.84A 3oxcA-5wkaA:
undetectable		 3oxcA-5wkaA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5wka BETA-GLUCOSIDASE
(metagenome) 		5 / 9 ALA A  71
ASN A 290
ILE A 367
GLU A 369
THR A  12
 None
None
None
GOL  A 501 (-3.4A)
None
 1.18A 3rukC-5wkaA:
undetectable		 3rukC-5wkaA:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UZZ_B_ASDB501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 5wka BETA-GLUCOSIDASE
(metagenome) 		4 / 8 TYR A 170
TYR A 116
LEU A 124
TRP A  78
 None
 1.41A 3uzzB-5wkaA:
10.4		 3uzzB-5wkaA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_A_CLQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5wka BETA-GLUCOSIDASE
(metagenome) 		5 / 12 GLY A 288
ILE A 367
VAL A 220
ILE A 356
PHE A 250
 None
 1.22A 4fglA-5wkaA:
undetectable
4fglB-5wkaA:
undetectable		 4fglA-5wkaA:
undetectable
4fglB-5wkaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 5wka BETA-GLUCOSIDASE
(metagenome) 		5 / 12 ILE A  17
ALA A  14
LEU A 100
PRO A 111
LEU A  64
 None
 1.17A 4gh8A-5wkaA:
undetectable		 4gh8A-5wkaA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_B_FOLB301_1
(FOLATE RECEPTOR
ALPHA)		 5wka BETA-GLUCOSIDASE
(metagenome) 		3 / 3 ASP A 119
TRP A 416
SER A  75
 None
GOL  A 501 (-3.8A)
None
 0.99A 4lrhB-5wkaA:
undetectable		 4lrhB-5wkaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_1
(PROLINE--TRNA LIGASE)		 5wka BETA-GLUCOSIDASE
(metagenome) 		3 / 3 GLU A 423
THR A 164
HIS A 175
 GOL  A 501 (-3.2A)
None
None
 0.86A 4q15A-5wkaA:
undetectable		 4q15A-5wkaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_1
(PROLINE--TRNA LIGASE)		 5wka BETA-GLUCOSIDASE
(metagenome) 		3 / 3 GLU A 423
THR A 164
HIS A 175
 GOL  A 501 (-3.2A)
None
None
 0.86A 4q15B-5wkaA:
undetectable		 4q15B-5wkaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UAC_A_ACRA501_2
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))		 5wka BETA-GLUCOSIDASE
(metagenome) 		4 / 7 PRO A 177
GLU A 125
SER A 165
THR A 157
 None
 1.30A 4uacA-5wkaA:
undetectable		 4uacA-5wkaA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5wka BETA-GLUCOSIDASE
(metagenome) 		4 / 7 ILE A 284
GLY A 288
THR A 368
LEU A 112
 None
 0.78A 4zdzA-5wkaA:
0.1		 4zdzA-5wkaA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE3_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5wka BETA-GLUCOSIDASE
(metagenome) 		4 / 7 ILE A 284
GLY A 288
THR A 368
LEU A 112
 None
 0.80A 4ze3A-5wkaA:
undetectable		 4ze3A-5wkaA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESM_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5wka BETA-GLUCOSIDASE
(metagenome) 		4 / 7 ILE A 284
GLY A 288
THR A 368
LEU A 112
 None
 0.79A 5esmA-5wkaA:
undetectable		 5esmA-5wkaA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		 5wka BETA-GLUCOSIDASE
(metagenome) 		4 / 8 TYR A 360
LEU A 218
TRP A 245
LEU A 216
 None
 1.09A 5hs6A-5wkaA:
2.1		 5hs6A-5wkaA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA502_1
(CYTOCHROME P450 2C9)		 5wka BETA-GLUCOSIDASE
(metagenome) 		5 / 12 ALA A 399
ASN A 370
VAL A 344
ASP A 345
GLY A 293
 None
None
None
None
PEG  A 502 (-4.3A)
 1.21A 5x24A-5wkaA:
undetectable		 5x24A-5wkaA:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 5wka BETA-GLUCOSIDASE
(metagenome) 		4 / 6 GLY A 442
ASP A 438
ARG A 444
ARG A 443
 None
 1.13A 6dwdA-5wkaA:
undetectable
6dwdC-5wkaA:
undetectable		 6dwdA-5wkaA:
undetectable
6dwdC-5wkaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 5wka BETA-GLUCOSIDASE
(metagenome) 		4 / 5 GLY A 442
ASP A 438
ARG A 444
ARG A 443
 None
 1.12A 6dwdB-5wkaA:
undetectable
6dwdD-5wkaA:
undetectable		 6dwdB-5wkaA:
undetectable
6dwdD-5wkaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWJ_B_GLYB710_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 5wka BETA-GLUCOSIDASE
(metagenome) 		4 / 5 ARG A 444
ARG A 443
GLY A 442
ASP A 438
 None
 1.18A 6dwjB-5wkaA:
undetectable
6dwjD-5wkaA:
undetectable		 6dwjB-5wkaA:
undetectable
6dwjD-5wkaA:
undetectable