SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wkh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 5wkh D30 TCR BETA CHAIN
T-CELL RECEPTOR
ALPHA VARIABLE
30,T-CELL RECEPTOR,
SP3.4 ALPHA CHAIN
(Homo
sapiens) 		4 / 8 ASP D 149
ASP D 128
TYR D 132
THR E 154
 None
 1.48A 1ceaA-5wkhD:
undetectable
1ceaB-5wkhD:
undetectable		 1ceaA-5wkhD:
14.66
1ceaB-5wkhD:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E71_M_ASCM995_0
(MYROSINASE MA1)		 5wkh T-CELL RECEPTOR
ALPHA VARIABLE
30,T-CELL RECEPTOR,
SP3.4 ALPHA CHAIN
D30 TCR BETA CHAIN
(Homo
sapiens;
Homo
sapiens) 		4 / 7 ILE D  55
TYR D  42
PHE D 112
PHE E 121
 None
 1.12A 1e71M-5wkhD:
undetectable		 1e71M-5wkhD:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E72_M_ASCM995_0
(MYROSINASE MA1)		 5wkh T-CELL RECEPTOR
ALPHA VARIABLE
30,T-CELL RECEPTOR,
SP3.4 ALPHA CHAIN
D30 TCR BETA CHAIN
(Homo
sapiens;
Homo
sapiens) 		4 / 7 ILE D  55
TYR D  42
PHE D 112
PHE E 121
 None
 1.12A 1e72M-5wkhD:
undetectable		 1e72M-5wkhD:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_1
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 5wkh T-CELL RECEPTOR
ALPHA VARIABLE
30,T-CELL RECEPTOR,
SP3.4 ALPHA CHAIN
(Homo
sapiens) 		5 / 12 ALA D 130
THR D 148
ALA D 186
ILE D 204
PHE D 193
 None
 1.13A 2nyrA-5wkhD:
undetectable		 2nyrA-5wkhD:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_0
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5wkh T-CELL RECEPTOR
ALPHA VARIABLE
30,T-CELL RECEPTOR,
SP3.4 ALPHA CHAIN
D30 TCR BETA CHAIN
(Homo
sapiens;
Homo
sapiens) 		5 / 12 SER D 183
PHE D 199
ILE D 166
LEU E 210
GLU E 145
 None
 1.15A 3aocC-5wkhD:
undetectable		 3aocC-5wkhD:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FZG_A_SAMA300_0
(16S RRNA METHYLASE)		 5wkh T-CELL RECEPTOR
ALPHA VARIABLE
30,T-CELL RECEPTOR,
SP3.4 ALPHA CHAIN
D30 TCR BETA CHAIN
(Homo
sapiens;
Homo
sapiens) 		5 / 12 HIS D  40
SER D  33
GLY E 118
LEU E 116
GLN E  57
 None
 1.06A 3fzgA-5wkhD:
undetectable		 3fzgA-5wkhD:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_B_RABB602_2
(ADENOSYLHOMOCYSTEINA
SE)		 5wkh D30 TCR BETA CHAIN
T-CELL RECEPTOR
ALPHA VARIABLE
30,T-CELL RECEPTOR,
SP3.4 ALPHA CHAIN
(Homo
sapiens) 		4 / 5 GLN D 133
GLU E 150
THR E 154
HIS E 153
 None
 1.45A 3glqB-5wkhD:
undetectable		 3glqB-5wkhD:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5wkh D30 TCR BETA CHAIN
T-CELL RECEPTOR
ALPHA VARIABLE
30,T-CELL RECEPTOR,
SP3.4 ALPHA CHAIN
(Homo
sapiens) 		4 / 5 GLN D 133
GLU E 150
THR E 154
HIS E 153
 None
 1.43A 3n58A-5wkhD:
undetectable		 3n58A-5wkhD:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_B_QELB1_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 5wkh D30 TCR BETA CHAIN
T-CELL RECEPTOR
ALPHA VARIABLE
30,T-CELL RECEPTOR,
SP3.4 ALPHA CHAIN
(Homo
sapiens) 		5 / 11 THR E 120
ALA D  49
ILE D  51
PHE D  52
PRO E  50
 None
 1.31A 3qelA-5wkhE:
undetectable
3qelB-5wkhE:
undetectable		 3qelA-5wkhE:
20.26
3qelB-5wkhE:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		 5wkh T-CELL RECEPTOR
ALPHA VARIABLE
30,T-CELL RECEPTOR,
SP3.4 ALPHA CHAIN
(Homo
sapiens) 		4 / 6 ASP D 161
ASN D 197
ALA D 194
ASP D 163
 None
 1.19A 4mdbA-5wkhD:
undetectable		 4mdbA-5wkhD:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PE5_B_QELB920_1
(GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 1
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 5wkh D30 TCR BETA CHAIN
T-CELL RECEPTOR
ALPHA VARIABLE
30,T-CELL RECEPTOR,
SP3.4 ALPHA CHAIN
(Homo
sapiens) 		5 / 10 THR E 120
ALA D  49
ILE D  51
PHE D  52
PRO E  50
 None
 1.27A 4pe5A-5wkhE:
undetectable
4pe5B-5wkhE:
undetectable		 4pe5A-5wkhE:
15.39
4pe5B-5wkhE:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_3
(PROTEASE)		 5wkh T-CELL RECEPTOR
ALPHA VARIABLE
30,T-CELL RECEPTOR,
SP3.4 ALPHA CHAIN
(Homo
sapiens) 		3 / 3 ASP D 163
ASP D 161
ASN D 197
 None
 0.73A 4q5mA-5wkhD:
undetectable		 4q5mA-5wkhD:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5wkh D30 TCR BETA CHAIN
(Homo
sapiens) 		5 / 9 ALA E  78
PRO E  72
LEU E  71
ILE E  54
PHE E  76
 None
 1.43A 5i73A-5wkhE:
undetectable		 5i73A-5wkhE:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5wkh T-CELL RECEPTOR
ALPHA VARIABLE
30,T-CELL RECEPTOR,
SP3.4 ALPHA CHAIN
D30 TCR BETA CHAIN
(Homo
sapiens;
Homo
sapiens) 		3 / 3 ASP D 128
PHE D 179
ARG E 211
 None
 1.14A 5yw0A-5wkhD:
undetectable		 5yw0A-5wkhD:
22.33