SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wkn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3009_0
(BETA-CARBONIC
ANHYDRASE)		 5wkn NUCLEOPROTEIN
(Mammalian
rubulavirus
5) 		4 / 5 GLY A  71
LEU A  74
THR A  75
VAL A 102
 None
 1.04A 1ekjF-5wknA:
undetectable
1ekjG-5wknA:
undetectable		 1ekjF-5wknA:
undetectable
1ekjG-5wknA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XR2_B_C2FB1201_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 5wkn NUCLEOPROTEIN
(Mammalian
rubulavirus
5) 		4 / 8 LYS A 225
SER A  67
ARG A  69
GLU A 126
 None
 1.32A 1xr2B-5wknA:
undetectable		 1xr2B-5wknA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDK_A_C2FA1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 5wkn NUCLEOPROTEIN
(Mammalian
rubulavirus
5) 		5 / 11 TYR A 329
THR A 294
LEU A 277
SER A 290
LEU A 273
 None
 1.42A 2idkA-5wknA:
undetectable
2idkB-5wknA:
undetectable
2idkC-5wknA:
undetectable
2idkD-5wknA:
undetectable		 2idkA-5wknA:
undetectable
2idkB-5wknA:
undetectable
2idkC-5wknA:
undetectable
2idkD-5wknA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDK_B_C2FB1420_0
(GLYCINE
N-METHYLTRANSFERASE)		 5wkn NUCLEOPROTEIN
(Mammalian
rubulavirus
5) 		5 / 10 LEU A 273
SER A 290
LEU A 277
TYR A 329
THR A 294
 None
 1.43A 2idkA-5wknA:
undetectable
2idkB-5wknA:
undetectable
2idkC-5wknA:
undetectable
2idkD-5wknA:
undetectable		 2idkA-5wknA:
undetectable
2idkB-5wknA:
undetectable
2idkC-5wknA:
undetectable
2idkD-5wknA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 5wkn NUCLEOPROTEIN
(Mammalian
rubulavirus
5) 		5 / 12 LEU A 233
LEU A 171
ALA A 174
ILE A 219
MET A  76
 None
 1.11A 2jn3A-5wknA:
undetectable		 2jn3A-5wknA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2MJI_A_KTRA201_1
(FATTY ACID-BINDING
PROTEIN, INTESTINAL)		 5wkn NUCLEOPROTEIN
(Mammalian
rubulavirus
5) 		5 / 12 TYR A 335
THR A 272
LEU A 332
PHE A 289
LEU A 293
 None
 1.36A 2mjiA-5wknA:
undetectable		 2mjiA-5wknA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WM3_A_NFLA1301_1
(NMRA-LIKE FAMILY
DOMAIN CONTAINING
PROTEIN 1)		 5wkn NUCLEOPROTEIN
(Mammalian
rubulavirus
5) 		4 / 6 LEU A  74
THR A  75
LEU A  85
ASP A  92
 None
 0.84A 2wm3A-5wknA:
undetectable		 2wm3A-5wknA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_C_C2FC1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 5wkn NUCLEOPROTEIN
(Mammalian
rubulavirus
5) 		3 / 3 ARG A  57
PRO A 116
PHE A  54
 None
 0.99A 3thrC-5wknA:
undetectable		 3thrC-5wknA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_D_C2FD1200_0
(GLYCINE
N-METHYLTRANSFERASE)		 5wkn NUCLEOPROTEIN
(Mammalian
rubulavirus
5) 		5 / 12 LEU A 273
SER A 290
LEU A 277
TYR A 329
THR A 294
 None
 1.34A 3thrA-5wknA:
undetectable
3thrB-5wknA:
undetectable
3thrC-5wknA:
undetectable
3thrD-5wknA:
undetectable		 3thrA-5wknA:
undetectable
3thrB-5wknA:
undetectable
3thrC-5wknA:
undetectable
3thrD-5wknA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1507_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5wkn NUCLEOPROTEIN
(Mammalian
rubulavirus
5) 		3 / 3 ARG A 195
LYS A 192
ARG A 216
 None
 1.46A 3w1wA-5wknA:
undetectable
3w1wB-5wknA:
undetectable		 3w1wA-5wknA:
undetectable
3w1wB-5wknA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_B_LOCB502_1
(TUBULIN BETA CHAIN)		 5wkn NUCLEOPROTEIN
(Mammalian
rubulavirus
5) 		5 / 12 LEU A  73
THR A 178
ALA A 174
VAL A 170
ILE A 219
 None
 1.11A 4x1yB-5wknA:
undetectable		 4x1yB-5wknA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_2
(TUBULIN BETA CHAIN)		 5wkn NUCLEOPROTEIN
(Mammalian
rubulavirus
5) 		5 / 11 LEU A  73
THR A 178
ALA A 174
VAL A 170
ILE A 219
 None
 1.08A 4x20D-5wknA:
undetectable		 4x20D-5wknA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 5wkn NUCLEOPROTEIN
(Mammalian
rubulavirus
5) 		4 / 5 SER A  81
ARG A 241
GLY A 258
GLU A 262
 None
 1.12A 5btiA-5wknA:
undetectable
5btiB-5wknA:
undetectable		 5btiA-5wknA:
11.70
5btiB-5wknA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5wkn NUCLEOPROTEIN
(Mammalian
rubulavirus
5) 		4 / 5 SER A  81
ARG A 241
GLY A 258
GLU A 262
 None
 1.08A 5btiC-5wknA:
undetectable
5btiD-5wknA:
undetectable		 5btiC-5wknA:
11.70
5btiD-5wknA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_2
(CYTOCHROME P450 3A4)		 5wkn NUCLEOPROTEIN
(Mammalian
rubulavirus
5) 		3 / 3 ARG A 119
ARG A 113
ARG A 124
 None
 0.96A 5vcgA-5wknA:
undetectable		 5vcgA-5wknA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_1
(CYTOCHROME P450 2C9)		 5wkn NUCLEOPROTEIN
(Mammalian
rubulavirus
5) 		5 / 12 VAL A  34
GLY A  71
ALA A  72
LEU A  79
LEU A  51
 None
 1.08A 5xxiA-5wknA:
undetectable		 5xxiA-5wknA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 5wkn NUCLEOPROTEIN
(Mammalian
rubulavirus
5) 		4 / 5 PHE A  77
THR A  75
GLU A 236
ASN A 248
 None
 1.41A 5ybbA-5wknA:
undetectable		 5ybbA-5wknA:
undetectable