SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wl2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1867_0
(FPRA)		 5wl2 -
(-) 		4 / 4 ALA H  40
ARG H  38
GLN H  43
GLU H  46
 None
 0.77A 1lqtB-5wl2H:
undetectable		 1lqtB-5wl2H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1424_0
(FPRA)		 5wl2 -
(-) 		4 / 4 ALA H  40
ARG H  38
GLN H  43
GLU H  46
 None
 0.81A 1lquB-5wl2H:
undetectable		 1lquB-5wl2H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZY_A_CHDA237_0
(PHOSPHOLIPASE A2,
MAJOR ISOENZYME)		 5wl2 -
(-) 		5 / 11 ARG H  98
ILE H  34
ILE H  51
GLY H 112
TYR H  80
 None
 1.21A 2azyA-5wl2H:
undetectable		 2azyA-5wl2H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_A_BEZA1529_0
(BENZOATE-COENZYME A
LIGASE)		 5wl2 -
(-) 		5 / 9 ALA H  61
TYR H  60
ALA H  58
GLY H  50
ILE H  70
 None
 1.21A 2v7bA-5wl2H:
undetectable		 2v7bA-5wl2H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_B_BEZB1529_0
(BENZOATE-COENZYME A
LIGASE)		 5wl2 -
(-) 		5 / 9 ALA H  61
TYR H  60
ALA H  58
GLY H  50
ILE H  70
 None
 1.20A 2v7bB-5wl2H:
undetectable		 2v7bB-5wl2H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5wl2 -
(-) 		5 / 12 SER H 196
GLY H 142
THR H 143
ALA H 144
THR H 139
 None
 0.88A 4qvpH-5wl2H:
undetectable
4qvpI-5wl2H:
undetectable		 4qvpH-5wl2H:
undetectable
4qvpI-5wl2H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5wl2 -
(-) 		5 / 12 SER H 196
GLY H 142
THR H 143
ALA H 144
THR H 139
 None
 0.88A 4qvpV-5wl2H:
undetectable
4qvpW-5wl2H:
undetectable		 4qvpV-5wl2H:
undetectable
4qvpW-5wl2H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 5wl2 -
(-) 		5 / 11 SER H 196
GLY H 142
THR H 143
ALA H 144
THR H 139
 None
 0.94A 4qvvH-5wl2H:
undetectable		 4qvvH-5wl2H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 5wl2 -
(-) 		5 / 11 SER H 196
GLY H 142
THR H 143
ALA H 144
THR H 139
 None
 0.93A 4qvvV-5wl2H:
undetectable		 4qvvV-5wl2H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 5wl2 -
(-) 		5 / 11 SER H 196
GLY H 142
THR H 143
ALA H 144
THR H 139
 None
 0.93A 4qvyH-5wl2H:
undetectable		 4qvyH-5wl2H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5wl2 -
(-) 		5 / 12 SER H 196
GLY H 142
THR H 143
ALA H 144
THR H 139
 None
 0.93A 4qvyV-5wl2H:
undetectable
4qvyW-5wl2H:
undetectable		 4qvyV-5wl2H:
undetectable
4qvyW-5wl2H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5wl2 -
(-) 		5 / 11 SER H 196
GLY H 142
THR H 143
ALA H 144
THR H 139
 None
 0.92A 4qw0H-5wl2H:
undetectable
4qw0I-5wl2H:
undetectable		 4qw0H-5wl2H:
undetectable
4qw0I-5wl2H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5wl2 -
(-) 		5 / 11 SER H 196
GLY H 142
THR H 143
ALA H 144
THR H 139
 None
 0.92A 4qw0V-5wl2H:
undetectable
4qw0W-5wl2H:
undetectable		 4qw0V-5wl2H:
undetectable
4qw0W-5wl2H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5wl2 -
(-) 		5 / 11 SER H 196
GLY H 142
THR H 143
ALA H 144
THR H 139
 None
 0.89A 5bxnH-5wl2H:
undetectable
5bxnI-5wl2H:
undetectable		 5bxnH-5wl2H:
undetectable
5bxnI-5wl2H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5wl2 -
(-) 		5 / 12 SER H 196
GLY H 142
THR H 143
ALA H 144
THR H 139
 None
 0.91A 5cz7V-5wl2H:
undetectable
5cz7W-5wl2H:
undetectable		 5cz7V-5wl2H:
undetectable
5cz7W-5wl2H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 5wl2 -
(-) 		5 / 11 SER H 196
GLY H 142
THR H 143
ALA H 144
THR H 139
 None
 0.91A 5d0xV-5wl2H:
undetectable		 5d0xV-5wl2H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5wl2 -
(-) 		5 / 12 SER H 196
GLY H 142
THR H 143
ALA H 144
THR H 139
 None
 0.87A 5l5fH-5wl2H:
undetectable
5l5fI-5wl2H:
undetectable		 5l5fH-5wl2H:
undetectable
5l5fI-5wl2H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5wl2 -
(-) 		5 / 12 SER H 196
GLY H 142
THR H 143
ALA H 144
THR H 139
 None
 0.87A 5l5fV-5wl2H:
undetectable
5l5fW-5wl2H:
undetectable		 5l5fV-5wl2H:
undetectable
5l5fW-5wl2H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7M_B_68HB405_0
(BETA-1 ADRENERGIC
RECEPTOR)		 5wl2 -
(-) 		5 / 12 VAL H 171
VAL H 190
SER H 188
ASN H 205
ASN H 163
 None
 1.46A 6h7mB-5wl2H:
undetectable		 6h7mB-5wl2H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_H_BO2H301_0
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5wl2 -
(-) 		5 / 12 SER H 196
GLY H 142
THR H 143
ALA H 144
THR H 139
 None
 0.97A 6hwdH-5wl2H:
undetectable
6hwdI-5wl2H:
undetectable		 6hwdH-5wl2H:
undetectable
6hwdI-5wl2H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_V_BO2V301_0
(PROTEASOME SUBUNIT
BETA TYPE-2)		 5wl2 -
(-) 		5 / 11 SER H 196
GLY H 142
THR H 143
ALA H 144
THR H 139
 None
 0.98A 6hwdV-5wl2H:
undetectable		 6hwdV-5wl2H:
undetectable