SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wl3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA501_1
(YKOF)		 5wl3 ENGINEERED CHALCONE
ISOMERASE ANCR2
(unidentified) 		4 / 8 PHE A 137
LEU A 142
ILE A  96
ILE A  95
 None
 0.98A 1sbrA-5wl3A:
undetectable		 1sbrA-5wl3A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB503_1
(YKOF)		 5wl3 ENGINEERED CHALCONE
ISOMERASE ANCR2
(unidentified) 		4 / 7 PHE A 162
ILE A  96
ILE A  95
LYS A 144
 None
 0.93A 1sbrB-5wl3A:
undetectable		 1sbrB-5wl3A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1320_0
(CHLOROPEROXIDASE)		 5wl3 ENGINEERED CHALCONE
ISOMERASE ANCR2
(unidentified) 		4 / 6 PHE A 133
ILE A 112
VAL A 188
PHE A 189
 None
None
None
CL  A 301 (-4.9A)
 0.72A 2cizA-5wl3A:
undetectable		 2cizA-5wl3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_B_MRVB1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 5wl3 ENGINEERED CHALCONE
ISOMERASE ANCR2
(unidentified) 		4 / 5 TYR A 104
THR A  18
LEU A 168
THR A 164
 CL  A 301 (-4.5A)
None
None
None
 1.47A 4mbsB-5wl3A:
undetectable		 4mbsB-5wl3A:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_B_5D5B927_1
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 5wl3 ENGINEERED CHALCONE
ISOMERASE ANCR2
(unidentified) 		4 / 7 SER A 163
LYS A  92
PHE A 149
HIS A 151
 None
 1.42A 5dlvB-5wl3A:
1.2		 5dlvB-5wl3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUJ_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 5wl3 ENGINEERED CHALCONE
ISOMERASE ANCR2
(unidentified) 		5 / 8 ALA A 129
VAL A 176
PHE A 150
LEU A 158
VAL A 108
 None
 1.26A 5nujA-5wl3A:
1.1		 5nujA-5wl3A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NCS_A_ACTA303_0
(N-ACETYLNEURAMINIC
ACID (SIALIC ACID)
SYNTHETASE)		 5wl3 ENGINEERED CHALCONE
ISOMERASE ANCR2
(unidentified) 		3 / 3 ILE A  17
THR A  16
PRO A  19
 None
 0.60A 6ncsA-5wl3A:
undetectable		 6ncsA-5wl3A:
undetectable