SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wl7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQW_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN)		 5wl7 ENGINEERED CHALCONE
ISOMERASE ANCCHI*
(unidentified) 		5 / 12 PHE A 133
ILE A 160
THR A 188
VAL A  83
LEU A 116
 None
 1.21A 1kqwA-5wl7A:
1.1		 1kqwA-5wl7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5wl7 ENGINEERED CHALCONE
ISOMERASE ANCCHI*
(unidentified) 		5 / 11 THR A  46
PHE A 162
LEU A 185
PHE A 133
VAL A 108
 CL  A 302 (-3.4A)
None
None
None
None
 1.43A 1q23J-5wl7A:
undetectable		 1q23J-5wl7A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO6_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 5wl7 ENGINEERED CHALCONE
ISOMERASE ANCCHI*
(unidentified) 		5 / 12 ILE A 176
LEU A 158
ALA A  91
VAL A  93
THR A 112
 None
None
None
CL  A 302 (-4.6A)
None
 1.28A 2qo6A-5wl7A:
1.9		 2qo6A-5wl7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_0
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 5wl7 ENGINEERED CHALCONE
ISOMERASE ANCCHI*
(unidentified) 		5 / 12 PHE A 133
ILE A 160
THR A 188
VAL A  83
LEU A 116
 None
 1.19A 2rctA-5wl7A:
undetectable		 2rctA-5wl7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_C_SALC1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5wl7 ENGINEERED CHALCONE
ISOMERASE ANCCHI*
(unidentified) 		5 / 12 THR A 199
ILE A  48
GLY A  32
GLY A  30
ARG A  92
 None
 1.25A 2y7kC-5wl7A:
undetectable		 2y7kC-5wl7A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_A_SALA1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5wl7 ENGINEERED CHALCONE
ISOMERASE ANCCHI*
(unidentified) 		5 / 9 THR A 199
ILE A  48
GLY A  32
GLY A  30
ARG A  92
 None
 1.20A 2y7wA-5wl7A:
undetectable		 2y7wA-5wl7A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APX_A_Z80A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 5wl7 ENGINEERED CHALCONE
ISOMERASE ANCCHI*
(unidentified) 		5 / 12 VAL A 195
PHE A 133
LEU A 158
ALA A  91
TYR A 104
 None
None
None
None
CL  A 302 (-4.7A)
 1.30A 3apxA-5wl7A:
undetectable		 3apxA-5wl7A:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 5wl7 ENGINEERED CHALCONE
ISOMERASE ANCCHI*
(unidentified) 		5 / 12 ILE A  48
GLY A  49
VAL A  93
ILE A  17
ALA A  31
 None
None
CL  A 302 (-4.6A)
None
None
 0.99A 3fpjA-5wl7A:
undetectable		 3fpjA-5wl7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_A_LEIA16_0
(COIL SER L16D-PEN)		 5wl7 ENGINEERED CHALCONE
ISOMERASE ANCCHI*
(unidentified) 		4 / 6 GLN A  84
LEU A  82
LYS A 192
LEU A 190
 None
 0.94A 3h5gA-5wl7A:
undetectable
3h5gC-5wl7A:
undetectable		 3h5gA-5wl7A:
undetectable
3h5gC-5wl7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_1
(HIV-1 PROTEASE)		 5wl7 ENGINEERED CHALCONE
ISOMERASE ANCCHI*
(unidentified) 		5 / 10 LEU A  82
VAL A  73
GLY A 194
VAL A 195
VAL A 203
 None
 1.03A 3oxwA-5wl7A:
undetectable		 3oxwA-5wl7A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_D_FOZD316_0
(THYMIDYLATE SYNTHASE)		 5wl7 ENGINEERED CHALCONE
ISOMERASE ANCCHI*
(unidentified) 		5 / 12 LEU A 190
LEU A 210
GLY A 206
ILE A  57
ALA A  52
 None
 1.10A 3uwlD-5wl7A:
undetectable		 3uwlD-5wl7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		 5wl7 ENGINEERED CHALCONE
ISOMERASE ANCCHI*
(unidentified) 		5 / 12 ILE A  48
LEU A 190
GLY A 191
VAL A 203
ALA A 204
 None
 1.18A 4fqsA-5wl7A:
undetectable		 4fqsA-5wl7A:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		 5wl7 ENGINEERED CHALCONE
ISOMERASE ANCCHI*
(unidentified) 		5 / 12 ILE A  48
LEU A 190
GLY A 191
VAL A 203
ALA A 204
 None
 1.18A 4fqsB-5wl7A:
undetectable		 4fqsB-5wl7A:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 5wl7 ENGINEERED CHALCONE
ISOMERASE ANCCHI*
(unidentified) 		5 / 12 PHE A 133
ILE A 160
THR A 188
VAL A  83
LEU A 116
 None
 1.20A 4qynA-5wl7A:
undetectable		 4qynA-5wl7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5wl7 ENGINEERED CHALCONE
ISOMERASE ANCCHI*
(unidentified) 		5 / 12 ALA A 129
PHE A  13
ILE A  11
GLY A  32
MET A 189
 None
None
None
None
CL  A 302 ( 4.1A)
 1.34A 5jlcA-5wl7A:
undetectable		 5jlcA-5wl7A:
9.73