SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wlh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BRP_A_RTLA183_0
(RETINOL BINDING
PROTEIN)		 5wlh LBACAS13A H328A
(C2C2)
(Lachnospiraceae
bacterium
NK4A179) 		5 / 12 LEU A1363
GLY A1117
PHE A 505
LEU A1285
PHE A1049
 None
 1.26A 1brpA-5wlhA:
undetectable		 1brpA-5wlhA:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_B_CCSB417_0
(ESTROGEN RECEPTOR)		 5wlh LBACAS13A H328A
(C2C2)
(Lachnospiraceae
bacterium
NK4A179) 		4 / 6 PHE A1081
GLU A1084
LYS A1341
VAL A1347
 None
None
U  B  12 ( 2.8A)
None
 1.41A 1l2iB-5wlhA:
1.1		 1l2iB-5wlhA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA502_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5wlh LBACAS13A H328A
(C2C2)
(Lachnospiraceae
bacterium
NK4A179) 		4 / 6 ASN A 665
ARG A 893
ILE A 891
GLY A 889
 None
 1.09A 1oniA-5wlhA:
undetectable
1oniB-5wlhA:
undetectable		 1oniA-5wlhA:
7.59
1oniB-5wlhA:
7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD508_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5wlh LBACAS13A H328A
(C2C2)
(Lachnospiraceae
bacterium
NK4A179) 		4 / 6 ASN A 665
ARG A 893
ILE A 891
GLY A 889
 None
 1.03A 1oniD-5wlhA:
undetectable
1oniF-5wlhA:
undetectable		 1oniD-5wlhA:
7.59
1oniF-5wlhA:
7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI518_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5wlh LBACAS13A H328A
(C2C2)
(Lachnospiraceae
bacterium
NK4A179) 		4 / 7 ILE A 152
GLY A 151
PHE A 158
ASN A 160
 None
IOD  A1514 ( 4.4A)
None
None
 0.98A 1oniG-5wlhA:
undetectable
1oniI-5wlhA:
undetectable		 1oniG-5wlhA:
7.59
1oniI-5wlhA:
7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)		 5wlh LBACAS13A H328A
(C2C2)
(Lachnospiraceae
bacterium
NK4A179) 		3 / 3 PHE A 277
TYR A 445
TYR A 284
 None
 1.04A 1x70B-5wlhA:
undetectable		 1x70B-5wlhA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BJF_A_DXCA330_0
(CHOLOYLGLYCINE
HYDROLASE)		 5wlh LBACAS13A H328A
(C2C2)
(Lachnospiraceae
bacterium
NK4A179) 		5 / 12 TYR A1263
PHE A1259
PHE A1365
ALA A1112
ILE A1327
 None
 1.11A 2bjfA-5wlhA:
undetectable		 2bjfA-5wlhA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		 5wlh LBACAS13A H328A
(C2C2)
(Lachnospiraceae
bacterium
NK4A179) 		4 / 6 ASP A1055
ARG A1355
ASP A1353
ASP A1061
 None
 1.24A 2j2pE-5wlhA:
undetectable
2j2pF-5wlhA:
undetectable		 2j2pE-5wlhA:
10.38
2j2pF-5wlhA:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 5wlh LBACAS13A H328A
(C2C2)
(Lachnospiraceae
bacterium
NK4A179) 		4 / 6 LEU A 996
ASN A1014
GLN A1021
ILE A1062
 None
 0.90A 2jn3A-5wlhA:
undetectable		 2jn3A-5wlhA:
7.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMJ_A_ACRA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 5wlh LBACAS13A H328A
(C2C2)
(Lachnospiraceae
bacterium
NK4A179) 		5 / 12 ASP A 931
ILE A 809
ILE A 793
ARG A 934
ALA A  19
 A  B  -6 ( 3.9A)
None
None
None
None
 1.47A 2qmjA-5wlhA:
undetectable		 2qmjA-5wlhA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_B_LDPB502_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 5wlh LBACAS13A H328A
(C2C2)
(Lachnospiraceae
bacterium
NK4A179) 		4 / 5 GLN A 914
PHE A 505
PHE A1249
GLY A1045
 IOD  A1509 ( 4.7A)
None
None
None
 1.42A 2qmzA-5wlhA:
undetectable
2qmzB-5wlhA:
undetectable		 2qmzA-5wlhA:
10.07
2qmzB-5wlhA:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5wlh LBACAS13A H328A
(C2C2)
(Lachnospiraceae
bacterium
NK4A179) 		4 / 6 GLY A 309
GLY A 374
GLN A 371
PHE A 338
 None
 0.89A 2qx6A-5wlhA:
undetectable
2qx6B-5wlhA:
undetectable		 2qx6A-5wlhA:
10.07
2qx6B-5wlhA:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_CHDA332_0
(CHOLOYLGLYCINE
HYDROLASE)		 5wlh LBACAS13A H328A
(C2C2)
(Lachnospiraceae
bacterium
NK4A179) 		5 / 12 PHE A1259
PHE A1365
ALA A1112
ILE A1361
ILE A1327
 None
 1.18A 2rlcA-5wlhA:
undetectable		 2rlcA-5wlhA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 5wlh LBACAS13A H328A
(C2C2)
(Lachnospiraceae
bacterium
NK4A179) 		5 / 12 TYR A 904
LEU A 561
ILE A 905
PHE A 909
PHE A 588
 None
 0.94A 2weyA-5wlhA:
undetectable		 2weyA-5wlhA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_H_TC9H1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5wlh LBACAS13A H328A
(C2C2)
(Lachnospiraceae
bacterium
NK4A179) 		4 / 7 TYR A 477
MET A 245
ILE A 481
SER A 946
 None
A  B  -5 ( 3.5A)
None
None
 1.20A 2xytI-5wlhA:
undetectable		 2xytI-5wlhA:
8.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5wlh LBACAS13A H328A
(C2C2)
(Lachnospiraceae
bacterium
NK4A179) 		4 / 8 THR A 514
GLN A 513
SER A 512
TYR A1044
 None
 1.36A 2xz5A-5wlhA:
undetectable
2xz5C-5wlhA:
undetectable		 2xz5A-5wlhA:
8.58
2xz5C-5wlhA:
8.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM8_A_ACAA511_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5wlh LBACAS13A H328A
(C2C2)
(Lachnospiraceae
bacterium
NK4A179) 		4 / 8 ALA A 491
ILE A 947
ILE A 932
TYR A 933
 None
 1.02A 2zm8A-5wlhA:
undetectable		 2zm8A-5wlhA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5wlh LBACAS13A H328A
(C2C2)
(Lachnospiraceae
bacterium
NK4A179) 		4 / 8 ALA A 447
ILE A 257
ILE A 443
TYR A 440
 None
None
None
C  B -20 ( 4.5A)
 1.06A 2zmaA-5wlhA:
undetectable		 2zmaA-5wlhA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_E_VD3E2001_1
(VITAMIN D
HYDROXYLASE)		 5wlh LBACAS13A H328A
(C2C2)
(Lachnospiraceae
bacterium
NK4A179) 		5 / 12 ILE A 560
LYS A 530
ASN A 545
LEU A 592
LEU A 579
 None
 1.26A 3a50E-5wlhA:
undetectable		 3a50E-5wlhA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_D_VDYD6178_1
(VITAMIN D
HYDROXYLASE)		 5wlh LBACAS13A H328A
(C2C2)
(Lachnospiraceae
bacterium
NK4A179) 		5 / 12 ILE A 560
LYS A 530
ASN A 545
LEU A 592
LEU A 579
 None
 1.22A 3a51D-5wlhA:
1.1		 3a51D-5wlhA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_1
(N,N-DIMETHYLTRANSFER
ASE)		 5wlh LBACAS13A H328A
(C2C2)
(Lachnospiraceae
bacterium
NK4A179) 		3 / 3 TYR A 933
GLU A 492
ASP A 602
 None
 0.63A 3bxoA-5wlhA:
undetectable		 3bxoA-5wlhA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_1
(N,N-DIMETHYLTRANSFER
ASE)		 5wlh LBACAS13A H328A
(C2C2)
(Lachnospiraceae
bacterium
NK4A179) 		3 / 3 TYR A 933
GLU A 492
ASP A 602
 None
 0.51A 3bxoB-5wlhA:
undetectable		 3bxoB-5wlhA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_B_LOCB700_2
(TUBULIN BETA-2B
CHAIN)		 5wlh LBACAS13A H328A
(C2C2)
(Lachnospiraceae
bacterium
NK4A179) 		5 / 11 LEU A 200
ALA A 203
LYS A 163
ASN A 160
VAL A 215
 None
 1.20A 3e22B-5wlhA:
undetectable		 3e22B-5wlhA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_D_LOCD700_2
(TUBULIN BETA-2B
CHAIN)		 5wlh LBACAS13A H328A
(C2C2)
(Lachnospiraceae
bacterium
NK4A179) 		5 / 11 LEU A 200
ALA A 203
LYS A 163
ASN A 160
VAL A 215
 None
 1.20A 3e22D-5wlhA:
undetectable		 3e22D-5wlhA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9X_A_NIMA1_1
(LACTOTRANSFERRIN')		 5wlh LBACAS13A H328A
(C2C2)
(Lachnospiraceae
bacterium
NK4A179) 		4 / 4 GLU A 938
GLY A 940
THR A 941
GLU A 942
 None
 1.27A 3e9xA-5wlhA:
undetectable		 3e9xA-5wlhA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_D_TOPD200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5wlh LBACAS13A H328A
(C2C2)
(Lachnospiraceae
bacterium
NK4A179) 		5 / 9 GLU A 628
ILE A 560
LEU A 592
PHE A 909
TYR A1044
 None
 1.21A 3fl9D-5wlhA:
undetectable		 3fl9D-5wlhA:
7.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		 5wlh LBACAS13A H328A
(C2C2)
(Lachnospiraceae
bacterium
NK4A179) 		5 / 11 SER A 568
SER A 979
GLY A 566
SER A 976
LEU A1043
 None
 1.37A 3iluB-5wlhA:
undetectable
3iluE-5wlhA:
undetectable		 3iluB-5wlhA:
11.69
3iluE-5wlhA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP3_B_AICB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5wlh LBACAS13A H328A
(C2C2)
(Lachnospiraceae
bacterium
NK4A179) 		3 / 3 ALA A 936
ARG A 935
LYS A  20
 None
A  B  -6 ( 4.4A)
A  B  -6 ( 4.6A)
 0.89A 3kp3B-5wlhA:
0.6		 3kp3B-5wlhA:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP5_B_KANB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5wlh LBACAS13A H328A
(C2C2)
(Lachnospiraceae
bacterium
NK4A179) 		3 / 3 ALA A 936
ARG A 935
LYS A  20
 None
A  B  -6 ( 4.4A)
A  B  -6 ( 4.6A)
 0.94A 3kp5B-5wlhA:
1.0		 3kp5B-5wlhA:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5wlh LBACAS13A H328A
(C2C2)
(Lachnospiraceae
bacterium
NK4A179) 		4 / 6 VAL A 304
VAL A 383
ILE A 405
ARG A 297
 None
 0.85A 3ms9A-5wlhA:
undetectable		 3ms9A-5wlhA:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5wlh LBACAS13A H328A
(C2C2)
(Lachnospiraceae
bacterium
NK4A179) 		4 / 6 VAL A 304
VAL A 383
ILE A 405
ARG A 297
 None
 0.89A 3mssA-5wlhA:
undetectable		 3mssA-5wlhA:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5wlh LBACAS13A H328A
(C2C2)
(Lachnospiraceae
bacterium
NK4A179) 		4 / 6 VAL A 304
VAL A 383
ILE A 405
ARG A 297
 None
 0.88A 3mssC-5wlhA:
undetectable		 3mssC-5wlhA:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_B_DSFB319_1
(GLR4197 PROTEIN)		 5wlh LBACAS13A H328A
(C2C2)
(Lachnospiraceae
bacterium
NK4A179) 		5 / 9 TYR A1334
ILE A1376
VAL A1294
ILE A1361
ILE A1360
 None
 1.16A 3p4wB-5wlhA:
1.3		 3p4wB-5wlhA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_D_DSFD319_1
(GLR4197 PROTEIN)		 5wlh LBACAS13A H328A
(C2C2)
(Lachnospiraceae
bacterium
NK4A179) 		5 / 10 TYR A1334
ILE A1376
VAL A1294
ILE A1361
ILE A1360
 None
 1.15A 3p4wD-5wlhA:
1.9		 3p4wD-5wlhA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_E_DSFE319_1
(GLR4197 PROTEIN)		 5wlh LBACAS13A H328A
(C2C2)
(Lachnospiraceae
bacterium
NK4A179) 		5 / 10 TYR A1334
ILE A1376
VAL A1294
ILE A1361
ILE A1360
 None
 1.17A 3p4wE-5wlhA:
1.7		 3p4wE-5wlhA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PEO_A_CU9A301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5wlh LBACAS13A H328A
(C2C2)
(Lachnospiraceae
bacterium
NK4A179) 		5 / 12 TYR A 477
MET A 245
ILE A 481
SER A 946
TYR A 933
 None
A  B  -5 ( 3.5A)
None
None
None
 1.30A 3peoA-5wlhA:
0.0
3peoE-5wlhA:
0.0		 3peoA-5wlhA:
8.97
3peoE-5wlhA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_1
(N-METHYLTRANSFERASE)		 5wlh LBACAS13A H328A
(C2C2)
(Lachnospiraceae
bacterium
NK4A179) 		3 / 3 TYR A1223
TYR A1177
GLU A1231
 None
 0.69A 3pfgA-5wlhA:
undetectable		 3pfgA-5wlhA:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PMZ_E_TUBE220_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5wlh LBACAS13A H328A
(C2C2)
(Lachnospiraceae
bacterium
NK4A179) 		4 / 6 TYR A 477
MET A 245
ILE A 481
SER A 946
 None
A  B  -5 ( 3.5A)
None
None
 1.34A 3pmzD-5wlhA:
undetectable		 3pmzD-5wlhA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 5wlh LBACAS13A H328A
(C2C2)
(Lachnospiraceae
bacterium
NK4A179) 		4 / 6 VAL A 304
VAL A 383
ILE A 405
ARG A 297
 None
 0.80A 3pyyA-5wlhA:
undetectable		 3pyyA-5wlhA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_C_BEZC264_0
(CARNITINYL-COA
DEHYDRATASE)		 5wlh LBACAS13A H328A
(C2C2)
(Lachnospiraceae
bacterium
NK4A179) 		4 / 6 ALA A 936
ILE A 943
GLU A 487
ALA A  22
 None
None
A  B  -6 ( 3.4A)
A  B  -5 ( 4.8A)
 0.88A 3r9sC-5wlhA:
undetectable		 3r9sC-5wlhA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_B_ZPCB1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5wlh LBACAS13A H328A
(C2C2)
(Lachnospiraceae
bacterium
NK4A179) 		5 / 12 PHE A 675
ILE A 855
TYR A 719
VAL A 862
PHE A 640
 None
None
A  B   6 ( 4.8A)
None
None
 1.49A 4a97A-5wlhA:
1.5
4a97B-5wlhA:
1.2		 4a97A-5wlhA:
11.63
4a97B-5wlhA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9W_A_VGHA1158_1
(7,8-DIHYDRO-8-OXOGUA
NINE TRIPHOSPHATASE)		 5wlh LBACAS13A H328A
(C2C2)
(Lachnospiraceae
bacterium
NK4A179) 		5 / 12 LEU A 863
PHE A 721
PHE A 684
VAL A 862
PHE A 679
 None
 1.27A 4c9wA-5wlhA:
undetectable		 4c9wA-5wlhA:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T44A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 5wlh LBACAS13A H328A
(C2C2)
(Lachnospiraceae
bacterium
NK4A179) 		4 / 6 SER A  61
VAL A  17
THR A  16
ARG A  58
 None
None
G  B  -8 ( 2.7A)
None
 1.19A 4lnxA-5wlhA:
undetectable		 4lnxA-5wlhA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_B_CHDB102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5wlh LBACAS13A H328A
(C2C2)
(Lachnospiraceae
bacterium
NK4A179) 		5 / 11 LEU A1363
LEU A1364
GLU A1114
LEU A1115
LEU A1289
 None
 0.90A 4wg0B-5wlhA:
undetectable
4wg0C-5wlhA:
undetectable
4wg0D-5wlhA:
undetectable		 4wg0B-5wlhA:
1.09
4wg0C-5wlhA:
1.09
4wg0D-5wlhA:
1.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_D_CHDD102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5wlh LBACAS13A H328A
(C2C2)
(Lachnospiraceae
bacterium
NK4A179) 		5 / 11 LEU A1363
LEU A1364
GLU A1114
LEU A1115
LEU A1289
 None
 0.91A 4wg0D-5wlhA:
undetectable
4wg0E-5wlhA:
undetectable
4wg0F-5wlhA:
undetectable		 4wg0D-5wlhA:
1.09
4wg0E-5wlhA:
1.09
4wg0F-5wlhA:
1.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_J_CHDJ103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5wlh LBACAS13A H328A
(C2C2)
(Lachnospiraceae
bacterium
NK4A179) 		5 / 11 LEU A1363
LEU A1364
GLU A1114
LEU A1115
LEU A1289
 None
 0.99A 4wg0J-5wlhA:
undetectable
4wg0K-5wlhA:
undetectable
4wg0L-5wlhA:
undetectable		 4wg0J-5wlhA:
1.09
4wg0K-5wlhA:
1.09
4wg0L-5wlhA:
1.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 5wlh LBACAS13A H328A
(C2C2)
(Lachnospiraceae
bacterium
NK4A179) 		4 / 8 ARG A 191
ASP A 212
VAL A 215
ASP A 210
 None
 1.01A 4xqgA-5wlhA:
undetectable		 4xqgA-5wlhA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 5wlh LBACAS13A H328A
(C2C2)
(Lachnospiraceae
bacterium
NK4A179) 		4 / 8 ARG A 191
ASP A 212
VAL A 215
ASP A 210
 None
 1.02A 4xqgB-5wlhA:
undetectable		 4xqgB-5wlhA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 5wlh LBACAS13A H328A
(C2C2)
(Lachnospiraceae
bacterium
NK4A179) 		4 / 8 ARG A 298
ASP A 393
PHE A 392
VAL A 383
 IOD  A1512 ( 4.5A)
IOD  A1512 (-3.6A)
None
None
 1.13A 4xqgB-5wlhA:
undetectable		 4xqgB-5wlhA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YSH_B_GLYB401_0
(GLYCINE OXIDASE)		 5wlh LBACAS13A H328A
(C2C2)
(Lachnospiraceae
bacterium
NK4A179) 		4 / 6 PHE A1133
GLY A1136
TYR A 445
ALA A1140
 None
 1.29A 4yshB-5wlhA:
undetectable		 4yshB-5wlhA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_2_BEZ2801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 5wlh LBACAS13A H328A
(C2C2)
(Lachnospiraceae
bacterium
NK4A179) 		4 / 4 LEU A 808
ARG A 736
ILE A 805
ILE A 740
 None
 1.11A 5dzk2-5wlhA:
undetectable
5dzkM-5wlhA:
undetectable
5dzkN-5wlhA:
undetectable		 5dzk2-5wlhA:
0.99
5dzkM-5wlhA:
9.62
5dzkN-5wlhA:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_1
(DIHYDROFOLATE
REDUCTASE)		 5wlh LBACAS13A H328A
(C2C2)
(Lachnospiraceae
bacterium
NK4A179) 		3 / 3 ASP A 107
ARG A  95
ARG A 161
 None
 0.90A 5eajB-5wlhA:
undetectable		 5eajB-5wlhA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H1E_A_VDXA501_1
(VITAMIN D3 RECEPTOR)		 5wlh LBACAS13A H328A
(C2C2)
(Lachnospiraceae
bacterium
NK4A179) 		5 / 12 PHE A 277
LEU A 281
ILE A1229
SER A 442
HIS A1138
 None
 1.35A 5h1eA-5wlhA:
undetectable		 5h1eA-5wlhA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H1E_A_VDXA501_1
(VITAMIN D3 RECEPTOR)		 5wlh LBACAS13A H328A
(C2C2)
(Lachnospiraceae
bacterium
NK4A179) 		5 / 12 TYR A 981
LEU A 569
SER A 568
SER A 976
VAL A 634
 None
 1.39A 5h1eA-5wlhA:
undetectable		 5h1eA-5wlhA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_B_AC2B301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 5wlh LBACAS13A H328A
(C2C2)
(Lachnospiraceae
bacterium
NK4A179) 		5 / 10 SER A 924
MET A 494
GLU A 498
ASP A 931
ILE A 932
 A  B   2 ( 4.0A)
A  B  -2 ( 4.0A)
None
A  B  -6 ( 3.9A)
None
 1.02A 5i3cB-5wlhA:
undetectable		 5i3cB-5wlhA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5wlh LBACAS13A H328A
(C2C2)
(Lachnospiraceae
bacterium
NK4A179) 		3 / 3 TYR A 928
TYR A 477
SER A 482
 A  B  -6 (-3.4A)
None
None
 0.72A 5iktB-5wlhA:
undetectable		 5iktB-5wlhA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_E_PFLE406_1
(PROTON-GATED ION
CHANNEL)		 5wlh LBACAS13A H328A
(C2C2)
(Lachnospiraceae
bacterium
NK4A179) 		5 / 10 ILE A 166
ILE A  92
ILE A 178
ILE A 174
ILE A 175
 None
 0.90A 5murE-5wlhA:
undetectable		 5murE-5wlhA:
5.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDZ_A_ADNA905_1
(ATP-CITRATE SYNTHASE)		 5wlh LBACAS13A H328A
(C2C2)
(Lachnospiraceae
bacterium
NK4A179) 		4 / 6 THR A 559
ASP A 558
LEU A 556
ASP A 585
 None
 1.18A 5tdzA-5wlhA:
undetectable		 5tdzA-5wlhA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_B_RBFB201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 5wlh LBACAS13A H328A
(C2C2)
(Lachnospiraceae
bacterium
NK4A179) 		4 / 7 ARG A 908
TYR A 904
GLU A 628
LEU A 510
 None
 0.77A 5umwB-5wlhA:
undetectable
5umwE-5wlhA:
undetectable		 5umwB-5wlhA:
4.30
5umwE-5wlhA:
4.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 5wlh LBACAS13A H328A
(C2C2)
(Lachnospiraceae
bacterium
NK4A179) 		4 / 7 TYR A1277
ALA A 447
GLY A 449
TYR A 453
 A  B  -3 ( 4.7A)
None
None
None
 0.97A 5uxdA-5wlhA:
2.9		 5uxdA-5wlhA:
11.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5wlh LBACAS13A H328A
(C2C2)
(Lachnospiraceae
bacterium
NK4A179) 		4 / 5 LEU A 510
PHE A 909
LEU A 592
PHE A 588
 None
 1.01A 5x19C-5wlhA:
undetectable
5x19J-5wlhA:
undetectable		 5x19C-5wlhA:
9.83
5x19J-5wlhA:
4.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5wlh LBACAS13A H328A
(C2C2)
(Lachnospiraceae
bacterium
NK4A179) 		4 / 6 LEU A 460
ARG A1128
MET A1131
LEU A1135
 None
A  B  -3 ( 2.5A)
None
None
 1.05A 5x1fA-5wlhA:
undetectable
5x1fJ-5wlhA:
undetectable		 5x1fA-5wlhA:
15.64
5x1fJ-5wlhA:
4.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5wlh LBACAS13A H328A
(C2C2)
(Lachnospiraceae
bacterium
NK4A179) 		3 / 3 SER A1225
HIS A1138
TYR A1152
 None
 0.96A 5y2tA-5wlhA:
undetectable		 5y2tA-5wlhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 5wlh LBACAS13A H328A
(C2C2)
(Lachnospiraceae
bacterium
NK4A179) 		5 / 12 THR A1240
ILE A1239
LEU A 525
PHE A1270
TYR A1124
 None
 1.44A 6a93A-5wlhA:
2.6		 6a93A-5wlhA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 5wlh LBACAS13A H328A
(C2C2)
(Lachnospiraceae
bacterium
NK4A179) 		4 / 5 ILE A 855
PHE A 721
ASN A 709
TYR A 714
 None
 1.18A 6a93B-5wlhA:
undetectable		 6a93B-5wlhA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA603_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 5wlh LBACAS13A H328A
(C2C2)
(Lachnospiraceae
bacterium
NK4A179) 		3 / 3 TYR A 641
ASN A 644
LEU A 870
 None
U  B   7 ( 4.5A)
None
 0.68A 6b58A-5wlhA:
0.6		 6b58A-5wlhA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5wlh LBACAS13A H328A
(C2C2)
(Lachnospiraceae
bacterium
NK4A179) 		5 / 12 LEU A1285
SER A1359
ILE A1111
PHE A1049
THR A1054
 None
 1.24A 6djzB-5wlhA:
undetectable		 6djzB-5wlhA:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 5wlh LBACAS13A H328A
(C2C2)
(Lachnospiraceae
bacterium
NK4A179) 		4 / 8 ASP A 703
LYS A 706
GLU A 708
ARG A 681
 None
None
None
A  B   8 ( 4.3A)
 1.25A 6fbvD-5wlhA:
undetectable		 6fbvD-5wlhA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA811_0
(GEPHYRIN)		 5wlh LBACAS13A H328A
(C2C2)
(Lachnospiraceae
bacterium
NK4A179) 		3 / 3 LEU A 900
LEU A 890
ARG A 893
 None
 0.70A 6fgcA-5wlhA:
undetectable		 6fgcA-5wlhA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HZP_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 5wlh LBACAS13A H328A
(C2C2)
(Lachnospiraceae
bacterium
NK4A179) 		4 / 8 VAL A 680
ASN A 683
GLN A1087
ILE A1080
 IOD  A1510 ( 4.4A)
U  B  12 ( 3.1A)
None
None
 1.02A 6hzpA-5wlhA:
undetectable		 6hzpA-5wlhA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I0Y_A_TRPA3001_0
(23S RIBOSOMAL RNA
TRYPTOPHANASE OPERON
LEADER PEPTIDE)		 5wlh LBACAS13A H328A
(C2C2)
(Lachnospiraceae
bacterium
NK4A179) 		3 / 3 TRP A 930
ILE A 932
ASP A 931
 None
None
A  B  -6 ( 3.9A)
 0.84A 6i0y7-5wlhA:
undetectable		 6i0y7-5wlhA:
1.61