SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wls'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 5wls POLLEN RECEPTOR-LIKE
KINASE 3
(Arabidopsis
thaliana) 		4 / 5 ILE A  96
ILE A 130
ILE A  82
LEU A 165
 None
 0.85A 1zgyA-5wlsA:
undetectable		 1zgyA-5wlsA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_CHDA332_0
(CHOLOYLGLYCINE
HYDROLASE)		 5wls POLLEN RECEPTOR-LIKE
KINASE 3
(Arabidopsis
thaliana) 		5 / 12 ILE A  60
PHE A 110
ILE A  84
ILE A  82
LEU A  29
 None
 1.02A 2rlcA-5wlsA:
undetectable		 2rlcA-5wlsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_A_SAMA206_0
(UPF0217 PROTEIN
MJ1640)		 5wls POLLEN RECEPTOR-LIKE
KINASE 3
(Arabidopsis
thaliana) 		4 / 6 LEU A 194
GLY A 172
LEU A 192
SER A 191
 None
 0.84A 3aiaA-5wlsA:
undetectable		 3aiaA-5wlsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5wls POLLEN RECEPTOR-LIKE
KINASE 3
(Arabidopsis
thaliana) 		4 / 6 ILE A  96
ILE A 130
ILE A  82
LEU A 113
 None
 0.73A 4o8fB-5wlsA:
undetectable		 4o8fB-5wlsA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDJ_A_SAMA301_0
(MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE)		 5wls POLLEN RECEPTOR-LIKE
KINASE 3
(Arabidopsis
thaliana) 		5 / 12 VAL A  36
SER A 127
SER A  79
LEU A  98
LEU A 107
 None
None
NAG  A 301 (-4.2A)
None
None
 0.99A 4qdjA-5wlsA:
undetectable		 4qdjA-5wlsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB3_A_UEGA202_1
(YFIR)		 5wls POLLEN RECEPTOR-LIKE
KINASE 3
(Arabidopsis
thaliana) 		4 / 4 LEU A 192
ILE A 207
PRO A 180
LEU A 199
 None
 1.22A 5eb3A-5wlsA:
undetectable		 5eb3A-5wlsA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA502_1
(CYTOCHROME P450 2C9)		 5wls POLLEN RECEPTOR-LIKE
KINASE 3
(Arabidopsis
thaliana) 		4 / 6 PRO A 114
GLY A 115
LYS A 117
LYS A 142
 None
 1.04A 5xxiA-5wlsA:
undetectable		 5xxiA-5wlsA:
12.00