SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wly'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMI_A_BHSA1610_1
(NITRIC OXIDE
SYNTHASE)		 5wly UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE
(Escherichia
coli) 		4 / 8 SER A 224
ARG A  24
TRP A 219
GLU A 222
 None
 1.10A 1dmiA-5wlyA:
undetectable
1dmiB-5wlyA:
undetectable		 1dmiA-5wlyA:
10.73
1dmiB-5wlyA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IIU_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5wly UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE
(Escherichia
coli) 		5 / 11 LEU A 111
LEU A 103
ALA A  33
ALA A  35
LEU A  39
 None
 1.37A 1iiuA-5wlyA:
undetectable		 1iiuA-5wlyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_G_AG2G7003_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 5wly UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE
(Escherichia
coli) 		5 / 6 LEU A 118
ASP A 116
GLY A  78
ILE A  76
ARG A 151
 None
 1.45A 1mt1G-5wlyA:
undetectable
1mt1J-5wlyA:
undetectable		 1mt1G-5wlyA:
26.87
1mt1J-5wlyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 5wly UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE
(Escherichia
coli) 		5 / 12 ARG A 213
ASP A 116
ASN A  79
ASP A  81
GLY A  40
 None
None
MN  A 301 ( 2.7A)
None
None
 1.14A 1q8jA-5wlyA:
3.2		 1q8jA-5wlyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1321_0
(CHLOROPEROXIDASE)		 5wly UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE
(Escherichia
coli) 		4 / 5 LEU A  36
PHE A  22
VAL A  66
ALA A  30
 None
 1.07A 2cizA-5wlyA:
undetectable		 2cizA-5wlyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_E_RTLE177_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5wly UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE
(Escherichia
coli) 		5 / 11 LEU A  23
ALA A  65
ALA A  62
MET A  59
LEU A  11
 None
 1.21A 3bszE-5wlyA:
undetectable		 3bszE-5wlyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		 5wly UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE
(Escherichia
coli) 		4 / 8 PHE A  75
ASP A  49
PHE A  43
GLY A  85
 None
 0.81A 3c0zB-5wlyA:
undetectable		 3c0zB-5wlyA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5wly UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE
(Escherichia
coli) 		4 / 7 TRP A 219
GLU A 222
SER A 224
ARG A  24
 None
 1.06A 3dqtA-5wlyA:
undetectable
3dqtB-5wlyA:
undetectable		 3dqtA-5wlyA:
11.71
3dqtB-5wlyA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX1_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5wly UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE
(Escherichia
coli) 		4 / 8 TRP A 219
GLU A 222
SER A 224
ARG A  24
 None
 1.18A 3jx1A-5wlyA:
undetectable
3jx1B-5wlyA:
undetectable		 3jx1A-5wlyA:
12.77
3jx1B-5wlyA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5T_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 5wly UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE
(Escherichia
coli) 		4 / 7 SER A 224
ARG A  24
TRP A 219
GLU A 222
 None
 1.13A 3n5tA-5wlyA:
undetectable
3n5tB-5wlyA:
undetectable		 3n5tA-5wlyA:
10.73
3n5tB-5wlyA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5wly UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE
(Escherichia
coli) 		4 / 8 TRP A 219
GLU A 222
SER A 224
ARG A  24
 None
 1.18A 3nlrA-5wlyA:
undetectable
3nlrB-5wlyA:
undetectable		 3nlrA-5wlyA:
12.77
3nlrB-5wlyA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLY_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5wly UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE
(Escherichia
coli) 		4 / 8 TRP A 219
GLU A 222
SER A 224
ARG A  24
 None
 1.19A 3nlyA-5wlyA:
undetectable
3nlyB-5wlyA:
undetectable		 3nlyA-5wlyA:
13.32
3nlyB-5wlyA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQL_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5wly UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE
(Escherichia
coli) 		4 / 8 TRP A 219
GLU A 222
SER A 224
ARG A  24
 None
 1.15A 3rqlA-5wlyA:
undetectable
3rqlB-5wlyA:
undetectable		 3rqlA-5wlyA:
13.32
3rqlB-5wlyA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_C_9PLC1_1
(CYTOCHROME P450 2A13)		 5wly UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE
(Escherichia
coli) 		4 / 7 PHE A   5
ALA A  35
THR A   3
LEU A 105
 None
 0.92A 3t3sC-5wlyA:
undetectable		 3t3sC-5wlyA:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_D_9PLD501_1
(CYTOCHROME P450 2E1)		 5wly UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE
(Escherichia
coli) 		4 / 6 PHE A  22
LEU A  36
ALA A  60
LEU A  42
 None
 0.98A 3t3zD-5wlyA:
undetectable		 3t3zD-5wlyA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5wly UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE
(Escherichia
coli) 		4 / 8 TRP A 219
GLU A 222
SER A 224
ARG A  24
 None
 1.17A 4capA-5wlyA:
undetectable
4capB-5wlyA:
undetectable		 4capA-5wlyA:
13.32
4capB-5wlyA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D32_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5wly UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE
(Escherichia
coli) 		4 / 8 TRP A 219
GLU A 222
SER A 224
ARG A  24
 None
 1.24A 4d32A-5wlyA:
undetectable
4d32B-5wlyA:
undetectable		 4d32A-5wlyA:
13.32
4d32B-5wlyA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5J_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5wly UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE
(Escherichia
coli) 		4 / 7 TRP A 219
GLU A 222
SER A 224
ARG A  24
 None
 1.12A 4k5jA-5wlyA:
undetectable
4k5jB-5wlyA:
undetectable		 4k5jA-5wlyA:
10.76
4k5jB-5wlyA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 5wly UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE
(Escherichia
coli) 		5 / 12 LEU A  36
LEU A   4
ILE A   6
GLY A  28
LEU A  26
 None
 1.02A 4lmnA-5wlyA:
undetectable		 4lmnA-5wlyA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3Y_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5wly UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE
(Escherichia
coli) 		4 / 8 TRP A 219
GLU A 222
SER A 224
ARG A  24
 None
 1.19A 4v3yA-5wlyA:
undetectable
4v3yB-5wlyA:
undetectable		 4v3yA-5wlyA:
13.32
4v3yB-5wlyA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADL_B_H4BB600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 5wly UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE
(Escherichia
coli) 		4 / 7 TRP A 219
GLU A 222
SER A 224
ARG A  24
 None
 1.09A 5adlA-5wlyA:
undetectable
5adlB-5wlyA:
undetectable		 5adlA-5wlyA:
10.76
5adlB-5wlyA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ3_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5wly UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE
(Escherichia
coli) 		4 / 7 TRP A 219
GLU A 222
SER A 224
ARG A  24
 None
 1.10A 5fj3A-5wlyA:
undetectable
5fj3B-5wlyA:
undetectable		 5fj3A-5wlyA:
10.76
5fj3B-5wlyA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_C_ACTC302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5wly UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE
(Escherichia
coli) 		4 / 6 ASP A  41
HIS A  10
HIS A 197
HIS A 114
 MN  A 301 ( 2.7A)
MN  A 302 (-3.3A)
MN  A 302 (-3.3A)
MN  A 301 (-3.3A)
 1.00A 5nelB-5wlyA:
undetectable
5nelC-5wlyA:
undetectable		 5nelB-5wlyA:
undetectable
5nelC-5wlyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO7_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5wly UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE
(Escherichia
coli) 		4 / 8 SER A 224
ARG A  24
TRP A 219
GLU A 222
 None
 1.14A 5uo7A-5wlyA:
undetectable
5uo7B-5wlyA:
undetectable		 5uo7A-5wlyA:
11.66
5uo7B-5wlyA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO8_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5wly UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE
(Escherichia
coli) 		4 / 6 SER A 224
ARG A  24
TRP A 219
GLU A 222
 None
 1.09A 5uo8A-5wlyA:
undetectable
5uo8B-5wlyA:
undetectable		 5uo8A-5wlyA:
10.83
5uo8B-5wlyA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV7_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5wly UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE
(Escherichia
coli) 		4 / 7 TRP A 219
GLU A 222
SER A 224
ARG A  24
 None
 1.18A 5vv7A-5wlyA:
undetectable
5vv7B-5wlyA:
undetectable		 5vv7A-5wlyA:
10.76
5vv7B-5wlyA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVN_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5wly UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE
(Escherichia
coli) 		4 / 7 TRP A 219
GLU A 222
SER A 224
ARG A  24
 None
 1.13A 5vvnA-5wlyA:
undetectable
5vvnB-5wlyA:
undetectable		 5vvnA-5wlyA:
10.76
5vvnB-5wlyA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_1
(CYTOCHROME P450 2C9)		 5wly UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE
(Escherichia
coli) 		5 / 12 ALA A  30
PHE A  22
ALA A  60
LEU A  84
LEU A  42
 None
 0.98A 5x23A-5wlyA:
undetectable		 5x23A-5wlyA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_B_H4BB501_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5wly UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE
(Escherichia
coli) 		4 / 7 SER A 224
ARG A  24
TRP A 219
GLU A 222
 None
 1.17A 6av6A-5wlyA:
undetectable
6av6B-5wlyA:
undetectable		 6av6A-5wlyA:
20.00
6av6B-5wlyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5wly UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE
(Escherichia
coli) 		4 / 7 TRP A 219
GLU A 222
SER A 224
ARG A  24
 None
 1.35A 6av6C-5wlyA:
undetectable
6av6D-5wlyA:
undetectable		 6av6C-5wlyA:
20.00
6av6D-5wlyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5wly UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE
(Escherichia
coli) 		4 / 7 SER A 224
ARG A  24
TRP A 219
GLU A 222
 None
 1.15A 6av7A-5wlyA:
undetectable
6av7B-5wlyA:
undetectable		 6av7A-5wlyA:
20.00
6av7B-5wlyA:
20.00