SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wm0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)
5wm0 PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE

(Rattus
norvegicus)
4 / 7 LEU A 329
GLU A 324
LEU A 200
TYR A 205
None
1.25A 2w8yA-5wm0A:
undetectable
2w8yA-5wm0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3003_1
(TRANSCRIPTIONAL
REGULATOR TCAR)
5wm0 PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE

(Rattus
norvegicus)
4 / 6 ILE A  66
VAL A 191
LEU A 193
LEU A  86
None
0.71A 3kp6A-5wm0A:
undetectable
3kp6B-5wm0A:
undetectable
3kp6A-5wm0A:
undetectable
3kp6B-5wm0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA357_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)
5wm0 PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE

(Rattus
norvegicus)
3 / 3 HIS A 108
HIS A 172
HIS A 107
None
0.79A 3mihA-5wm0A:
45.2
3mihA-5wm0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA358_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)
5wm0 PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE

(Rattus
norvegicus)
3 / 3 HIS A 242
HIS A 244
MET A 314
None
0.32A 3mihA-5wm0A:
45.2
3mihA-5wm0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)
5wm0 PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE

(Rattus
norvegicus)
3 / 3 PRO A 151
LEU A 150
GLN A 198
None
0.63A 4pevB-5wm0A:
undetectable
4pevB-5wm0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_2
(GLUCOCORTICOID
RECEPTOR)
5wm0 PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE

(Rattus
norvegicus)
3 / 3 MET A 207
GLN A 266
TYR A 275
None
0.93A 4udcA-5wm0A:
undetectable
4udcA-5wm0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
5wm0 PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE

(Rattus
norvegicus)
5 / 12 GLY A 159
GLY A 163
THR A 162
ASN A 115
PHE A 167
None
1.19A 4zvmA-5wm0A:
undetectable
4zvmB-5wm0A:
undetectable
4zvmA-5wm0A:
undetectable
4zvmB-5wm0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)
5wm0 PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE

(Rattus
norvegicus)
3 / 3 THR A 284
MET A 234
HIS A 235
None
0.87A 5uunA-5wm0A:
undetectable
5uunA-5wm0A:
undetectable