SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wm4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 5wm4 SALICYLATE-AMP
LIGASE
(Streptomyces
gandocaensis) 		5 / 12 GLY A 120
LEU A 112
LEU A 208
LEU A  22
TYR A 414
 None
 1.39A 1fm6D-5wm4A:
undetectable		 1fm6D-5wm4A:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_X_BRLX504_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 5wm4 SALICYLATE-AMP
LIGASE
(Streptomyces
gandocaensis) 		5 / 12 ILE A  93
GLY A  94
LEU A 208
LEU A  22
TYR A 414
 None
 1.47A 1fm6X-5wm4A:
undetectable		 1fm6X-5wm4A:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG1_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 5wm4 SALICYLATE-AMP
LIGASE
(Streptomyces
gandocaensis) 		3 / 3 TRP A  25
VAL A  26
PRO A  27
 None
 0.98A 1rg1A-5wm4A:
undetectable		 1rg1A-5wm4A:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH0_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 5wm4 SALICYLATE-AMP
LIGASE
(Streptomyces
gandocaensis) 		3 / 3 TRP A  25
VAL A  26
PRO A  27
 None
 0.97A 1rh0A-5wm4A:
undetectable		 1rh0A-5wm4A:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5wm4 SALICYLATE-AMP
LIGASE
(Streptomyces
gandocaensis) 		5 / 12 ALA A 285
ILE A 289
VAL A 299
ALA A 298
LEU A 347
 None
None
None
None
GOL  A 609 (-4.4A)
 1.30A 1udtA-5wm4A:
undetectable		 1udtA-5wm4A:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_1
(VP39)		 5wm4 SALICYLATE-AMP
LIGASE
(Streptomyces
gandocaensis) 		3 / 3 ASP A 226
ARG A  37
ASP A 204
 None
 0.65A 1vptA-5wm4A:
undetectable		 1vptA-5wm4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 5wm4 SALICYLATE-AMP
LIGASE
(Streptomyces
gandocaensis) 		5 / 12 LEU A 259
LEU A 125
VAL A 101
PHE A 114
PHE A 109
 None
 1.30A 2weyA-5wm4A:
undetectable		 2weyA-5wm4A:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_2
(PHOSPHOLIPASE A2)		 5wm4 SALICYLATE-AMP
LIGASE
(Streptomyces
gandocaensis) 		4 / 6 VAL A 436
VAL A 445
GLN A 349
ARG A 437
 None
 1.17A 3bjwF-5wm4A:
undetectable		 3bjwF-5wm4A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_2
(PHOSPHOLIPASE A2)		 5wm4 SALICYLATE-AMP
LIGASE
(Streptomyces
gandocaensis) 		4 / 6 VAL A 100
GLY A 120
ARG A 118
LEU A 197
 None
 1.07A 3bjwE-5wm4A:
undetectable		 3bjwE-5wm4A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_2
(HIV-1 PROTEASE)		 5wm4 SALICYLATE-AMP
LIGASE
(Streptomyces
gandocaensis) 		3 / 3 ARG A 322
VAL A 274
THR A 267
 ACT  A 604 (-3.9A)
None
None
 0.77A 3cyxA-5wm4A:
undetectable		 3cyxA-5wm4A:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_DXCC576_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 5wm4 SALICYLATE-AMP
LIGASE
(Streptomyces
gandocaensis) 		5 / 8 ALA A 139
ALA A 144
ILE A 135
GLU A 134
THR A 126
 None
 1.45A 3dtuC-5wm4A:
undetectable
3dtuD-5wm4A:
undetectable		 3dtuC-5wm4A:
undetectable
3dtuD-5wm4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 5wm4 SALICYLATE-AMP
LIGASE
(Streptomyces
gandocaensis) 		5 / 12 SER A 329
GLY A 483
ARG A 492
VAL A 481
ILE A 461
 None
 1.31A 3jb2A-5wm4A:
undetectable		 3jb2A-5wm4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VN2_A_TLSA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5wm4 SALICYLATE-AMP
LIGASE
(Streptomyces
gandocaensis) 		5 / 12 PHE A 257
CYH A 261
SER A 235
TYR A 408
LEU A 209
 B5M  A 601 (-3.6A)
B5M  A 601 (-3.6A)
None
None
None
 1.24A 3vn2A-5wm4A:
undetectable		 3vn2A-5wm4A:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_B_NCTB501_1
(CYTOCHROME P450 2A13)		 5wm4 SALICYLATE-AMP
LIGASE
(Streptomyces
gandocaensis) 		4 / 8 PHE A 113
ALA A 260
LEU A 209
LEU A 125
 None
 0.77A 4ejgB-5wm4A:
undetectable		 4ejgB-5wm4A:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_C_NCTC501_1
(CYTOCHROME P450 2A13)		 5wm4 SALICYLATE-AMP
LIGASE
(Streptomyces
gandocaensis) 		5 / 7 PHE A 114
PHE A 113
ALA A 260
LEU A 209
LEU A 125
 None
 1.00A 4ejgC-5wm4A:
undetectable		 4ejgC-5wm4A:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_D_NCTD501_1
(CYTOCHROME P450 2A13)		 5wm4 SALICYLATE-AMP
LIGASE
(Streptomyces
gandocaensis) 		4 / 6 PHE A 113
PHE A 109
ALA A 260
LEU A 209
 None
 1.02A 4ejgD-5wm4A:
undetectable		 4ejgD-5wm4A:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_1
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 5wm4 SALICYLATE-AMP
LIGASE
(Streptomyces
gandocaensis) 		3 / 3 ASP A 226
ARG A  37
ASP A 204
 None
 0.69A 4fzvA-5wm4A:
undetectable		 4fzvA-5wm4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)		 5wm4 SALICYLATE-AMP
LIGASE
(Streptomyces
gandocaensis) 		5 / 12 LEU A 347
VAL A 326
ALA A 336
LEU A 343
LEU A 305
 GOL  A 609 (-4.4A)
None
None
None
None
 1.05A 4i1rA-5wm4A:
2.3		 4i1rA-5wm4A:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_D_PARD500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 5wm4 SALICYLATE-AMP
LIGASE
(Streptomyces
gandocaensis) 		4 / 8 PHE A 114
THR A 229
ASP A 227
ASP A 226
 None
 0.85A 4qb9D-5wm4A:
undetectable		 4qb9D-5wm4A:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_A_AERA602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 5wm4 SALICYLATE-AMP
LIGASE
(Streptomyces
gandocaensis) 		4 / 8 ALA A 416
ASN A 468
THR A 214
SER A 211
 ACT  A 603 (-3.5A)
None
None
None
 0.80A 4r20A-5wm4A:
undetectable		 4r20A-5wm4A:
9.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X3U_B_SVRB102_1
(CHROMOBOX PROTEIN
HOMOLOG 7)		 5wm4 SALICYLATE-AMP
LIGASE
(Streptomyces
gandocaensis) 		3 / 3 LYS A 545
ARG A 528
VAL A 529
 None
 0.94A 4x3uA-5wm4A:
undetectable
4x3uB-5wm4A:
undetectable		 4x3uA-5wm4A:
30.43
4x3uB-5wm4A:
30.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_H_TR6H101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 5wm4 SALICYLATE-AMP
LIGASE
(Streptomyces
gandocaensis) 		3 / 5 GLY A 352
GLY A 356
GLU A 355
 B5M  A 601 (-3.8A)
None
B5M  A 601 ( 4.8A)
 0.41A 4z2eA-5wm4A:
undetectable
4z2eD-5wm4A:
undetectable		 4z2eA-5wm4A:
9.40
4z2eD-5wm4A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_1
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 5wm4 SALICYLATE-AMP
LIGASE
(Streptomyces
gandocaensis) 		5 / 12 ALA A 236
SER A 235
VAL A 232
GLN A 325
TYR A 360
 None
 1.29A 4zj8A-5wm4A:
2.4		 4zj8A-5wm4A:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS1_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5wm4 SALICYLATE-AMP
LIGASE
(Streptomyces
gandocaensis) 		4 / 8 ILE A  62
GLY A  69
LEU A 288
LEU A 248
 None
 0.86A 5hs1A-5wm4A:
undetectable		 5hs1A-5wm4A:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 5wm4 SALICYLATE-AMP
LIGASE
(Streptomyces
gandocaensis) 		5 / 12 VAL A 122
LEU A 265
LEU A  47
ALA A 206
LEU A 209
 None
 1.18A 5nd7B-5wm4A:
undetectable		 5nd7B-5wm4A:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYE_B_TA1B502_1
(TUBULIN BETA CHAIN)		 5wm4 SALICYLATE-AMP
LIGASE
(Streptomyces
gandocaensis) 		5 / 12 GLU A  76
LEU A 187
ASP A 107
ALA A  81
PRO A 194
 None
 1.25A 5syeB-5wm4A:
undetectable		 5syeB-5wm4A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM2_A_ACTA605_0
(SALICYLATE-AMP
LIGASE)		 5wm4 SALICYLATE-AMP
LIGASE
(Streptomyces
gandocaensis) 		3 / 3 THR A 245
THR A 295
ARG A 322
 ACT  A 604 (-3.0A)
ACT  A 604 (-3.6A)
ACT  A 604 (-3.9A)
 0.09A 5wm2A-5wm4A:
71.8		 5wm2A-5wm4A:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WM2_A_SALA601_1
(SALICYLATE-AMP
LIGASE)		 5wm4 SALICYLATE-AMP
LIGASE
(Streptomyces
gandocaensis) 		6 / 9 HIS A 255
ASN A 256
CYH A 261
GLY A 327
GLY A 352
LEU A 358
 B5M  A 601 ( 4.8A)
B5M  A 601 (-3.9A)
B5M  A 601 (-3.6A)
B5M  A 601 (-3.6A)
B5M  A 601 (-3.8A)
None
 0.98A 5wm2A-5wm4A:
71.8		 5wm2A-5wm4A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WM2_A_SALA601_1
(SALICYLATE-AMP
LIGASE)		 5wm4 SALICYLATE-AMP
LIGASE
(Streptomyces
gandocaensis) 		9 / 9 HIS A 255
ASN A 256
PHE A 257
CYH A 261
GLY A 328
VAL A 350
GLY A 352
LEU A 358
LYS A 460
 B5M  A 601 ( 4.8A)
B5M  A 601 (-3.9A)
B5M  A 601 (-3.6A)
B5M  A 601 (-3.6A)
B5M  A 601 (-3.3A)
B5M  A 601 (-4.8A)
B5M  A 601 (-3.8A)
None
B5M  A 601 (-3.0A)
 0.19A 5wm2A-5wm4A:
71.8		 5wm2A-5wm4A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM7_A_ACTA603_0
(SALICYLATE-AMP
LIGASE)		 5wm4 SALICYLATE-AMP
LIGASE
(Streptomyces
gandocaensis) 		4 / 4 THR A 245
THR A 295
ALA A 296
ARG A 322
 ACT  A 604 (-3.0A)
ACT  A 604 (-3.6A)
ACT  A 604 ( 3.8A)
ACT  A 604 (-3.9A)
 0.10A 5wm7A-5wm4A:
71.5		 5wm7A-5wm4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 5wm4 SALICYLATE-AMP
LIGASE
(Streptomyces
gandocaensis) 		3 / 3 ASP A 226
ARG A  37
ASP A 204
 None
 0.78A 5zvgA-5wm4A:
undetectable		 5zvgA-5wm4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 5wm4 SALICYLATE-AMP
LIGASE
(Streptomyces
gandocaensis) 		3 / 3 ASP A 226
ARG A  37
ASP A 204
 None
 0.83A 5zvgB-5wm4A:
undetectable		 5zvgB-5wm4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CB4_A_BEZA501_0
(CANAVALIN)		 5wm4 SALICYLATE-AMP
LIGASE
(Streptomyces
gandocaensis) 		4 / 8 LEU A 324
VAL A 294
LEU A 321
ILE A 289
 None
 0.90A 6cb4A-5wm4A:
undetectable		 6cb4A-5wm4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCO_A_FY5A1003_0
(ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2)		 5wm4 SALICYLATE-AMP
LIGASE
(Streptomyces
gandocaensis) 		5 / 11 VAL A 498
MET A 532
THR A 543
ILE A 454
VAL A 482
 None
 1.35A 6hcoA-5wm4A:
undetectable
6hcoB-5wm4A:
undetectable		 6hcoA-5wm4A:
undetectable
6hcoB-5wm4A:
undetectable