SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wm9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1S9P_D_DESD600_1 (ESTROGEN-RELATED RECEPTOR GAMMA)	5wm9	RV0078 (Mycobacterium tuberculosis)	5 / 12	LEU A 159 ALA A 166 LEU A 191 LEU A 199 ILE A 142	LEU A 159 ( 0.6A) ALA A 166 ( 0.0A) LEU A 191 ( 0.5A) LEU A 199 ( 0.6A) ILE A 142 ( 0.7A)	1.13A	1s9pD-5wm9A: undetectable	1s9pD-5wm9A: 16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2VUF_A_FUAA2002_1 (SERUM ALBUMIN)	5wm9	RV0078 (Mycobacterium tuberculosis)	4 / 9	ILE A 113 PHE A 62 VAL A 66 GLU A 67	ILE A 113 ( 0.7A) PHE A 62 ( 1.3A) VAL A 66 ( 0.6A) GLU A 67 ( 0.6A)	0.82A	2vufA-5wm9A: 4.0	2vufA-5wm9A: 8.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XNR_A_ACTA1001_0 (NUCLEAR POLYADENYLATED RNA-BINDING PROTEIN 3)	5wm9	RV0078 (Mycobacterium tuberculosis)	3 / 3	SER A 12 ARG A 11 GLN A 8	SER A 12 ( 0.0A) ARG A 11 (-0.6A) GLN A 8 ( 0.6A)	0.98A	2xnrA-5wm9A: undetectable	2xnrA-5wm9A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3JAY_A_SAMA1102_1 (STRUCTURAL PROTEIN VP3)	5wm9	RV0078 (Mycobacterium tuberculosis)	3 / 3	ARG A 192 ASP A 91 ASP A 196	ARG A 192 ( 0.6A) ASP A 91 ( 0.6A) ASP A 196 ( 0.6A)	0.90A	3jayA-5wm9A: undetectable	3jayA-5wm9A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3K2H_A_LYAA514_1 (DIHYDROFOLATE REDUCTASE/THYMIDYLAT E SYNTHASE)	5wm9	RV0078 (Mycobacterium tuberculosis)	5 / 12	ALA A 166 THR A 138 ILE A 93 LEU A 151 LEU A 159	ALA A 166 ( 0.0A) THR A 138 ( 0.8A) ILE A 93 ( 0.7A) LEU A 151 ( 0.6A) LEU A 159 ( 0.6A)	1.13A	3k2hA-5wm9A: undetectable	3k2hA-5wm9A: 9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XQE_A_AG2A506_1 (HOMOSPERMIDINE SYNTHASE)	5wm9	RV0078 (Mycobacterium tuberculosis)	4 / 6	ARG A 76 ARG A 24 ASP A 106 VAL A 68	ARG A 76 ( 0.6A) ARG A 24 ( 0.6A) ASP A 106 ( 0.6A) VAL A 68 ( 0.6A)	1.33A	4xqeA-5wm9A: undetectable	4xqeA-5wm9A: 10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XQE_B_AG2B505_1 (HOMOSPERMIDINE SYNTHASE)	5wm9	RV0078 (Mycobacterium tuberculosis)	4 / 6	ARG A 76 ARG A 24 ASP A 106 VAL A 68	ARG A 76 ( 0.6A) ARG A 24 ( 0.6A) ASP A 106 ( 0.6A) VAL A 68 ( 0.6A)	1.33A	4xqeB-5wm9A: undetectable	4xqeB-5wm9A: 10.63

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1S9P_D_DESD600_1","ESTROGEN-RELATED RECEPTOR GAMMA","5wm9","RV0078","Mycobacterium tuberculosis",5,"LEU A 159;ALA A 166;LEU A 191;LEU A 199;ILE A 142","LEU A 159 ( 0.6A);ALA A 166 ( 0.0A);LEU A 191 ( 0.5A);LEU A 199 ( 0.6A);ILE A 142 ( 0.7A)","1.13A","1s9pD-5wm9A:undetectable","1s9pD-5wm9A:16.84"],["2VUF_A_FUAA2002_1","SERUM ALBUMIN","5wm9","RV0078","Mycobacterium tuberculosis",4,"ILE A 113;PHE A  62;VAL A  66;GLU A  67","ILE A 113 ( 0.7A);PHE A  62 ( 1.3A);VAL A  66 ( 0.6A);GLU A  67 ( 0.6A)","0.82A","2vufA-5wm9A:4.0","2vufA-5wm9A:8.06"],["2XNR_A_ACTA1001_0","NUCLEAR POLYADENYLATED RNA-BINDING PROTEIN 3","5wm9","RV0078","Mycobacterium tuberculosis",3,"SER A  12;ARG A  11;GLN A   8","SER A  12 ( 0.0A);ARG A  11 (-0.6A);GLN A   8 ( 0.6A)","0.98A","2xnrA-5wm9A:undetectable","2xnrA-5wm9A:undetectable"],["3JAY_A_SAMA1102_1","STRUCTURAL PROTEIN VP3","5wm9","RV0078","Mycobacterium tuberculosis",3,"ARG A 192;ASP A  91;ASP A 196","ARG A 192 ( 0.6A);ASP A  91 ( 0.6A);ASP A 196 ( 0.6A)","0.90A","3jayA-5wm9A:undetectable","3jayA-5wm9A:undetectable"],["3K2H_A_LYAA514_1","DIHYDROFOLATE REDUCTASE\/THYMIDYLATE SYNTHASE","5wm9","RV0078","Mycobacterium tuberculosis",5,"ALA A 166;THR A 138;ILE A  93;LEU A 151;LEU A 159","ALA A 166 ( 0.0A);THR A 138 ( 0.8A);ILE A  93 ( 0.7A);LEU A 151 ( 0.6A);LEU A 159 ( 0.6A)","1.13A","3k2hA-5wm9A:undetectable","3k2hA-5wm9A:9.98"],["4XQE_A_AG2A506_1","HOMOSPERMIDINE SYNTHASE","5wm9","RV0078","Mycobacterium tuberculosis",4,"ARG A  76;ARG A  24;ASP A 106;VAL A  68","ARG A  76 ( 0.6A);ARG A  24 ( 0.6A);ASP A 106 ( 0.6A);VAL A  68 ( 0.6A)","1.33A","4xqeA-5wm9A:undetectable","4xqeA-5wm9A:10.63"],["4XQE_B_AG2B505_1","HOMOSPERMIDINE SYNTHASE","5wm9","RV0078","Mycobacterium tuberculosis",4,"ARG A  76;ARG A  24;ASP A 106;VAL A  68","ARG A  76 ( 0.6A);ARG A  24 ( 0.6A);ASP A 106 ( 0.6A);VAL A  68 ( 0.6A)","1.33A","4xqeB-5wm9A:undetectable","4xqeB-5wm9A:10.63"]]