SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wmb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYR_A_TOPA407_1
(DIHYDROFOLATE
REDUCTASE)		 5wmb DNA REPAIR PROTEIN
REV1
(Saccharomyces
cerevisiae) 		5 / 11 ILE A 631
LEU A 666
ILE A 643
PHE A 642
ILE A 627
 None
 1.03A 1dyrA-5wmbA:
undetectable		 1dyrA-5wmbA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 5wmb DNA REPAIR PROTEIN
REV1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 631
PHE A 642
SER A 624
ILE A 625
LEU A 316
 None
 1.02A 1rx3A-5wmbA:
undetectable		 1rx3A-5wmbA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_A_BEZA11_0
(CES1 PROTEIN)		 5wmb DNA REPAIR PROTEIN
REV1
(Saccharomyces
cerevisiae) 		4 / 4 LEU A 574
SER A 586
LEU A 550
LEU A 547
 None
 1.17A 1yajA-5wmbA:
undetectable		 1yajA-5wmbA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_1
(O-METHYLTRANSFERASE)		 5wmb DNA REPAIR PROTEIN
REV1
(Saccharomyces
cerevisiae) 		4 / 4 ASP A 467
SER A 445
PHE A 448
SER A 507
 MG  A 801 (-2.2A)
EDO  A 811 (-3.0A)
None
None
 1.23A 3i5uA-5wmbA:
undetectable		 3i5uA-5wmbA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_1
(O-METHYLTRANSFERASE)		 5wmb DNA REPAIR PROTEIN
REV1
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 467
PHE A 448
SER A 507
 MG  A 801 (-2.2A)
None
None
 0.77A 3i5uB-5wmbA:
undetectable		 3i5uB-5wmbA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_1
(DIHYDROFOLATE
REDUCTASE)		 5wmb DNA REPAIR PROTEIN
REV1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 631
PHE A 642
SER A 624
ILE A 625
LEU A 316
 None
 1.18A 3ia4D-5wmbA:
undetectable		 3ia4D-5wmbA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_C_TFPC202_1
(PROTEIN S100-A4)		 5wmb DNA REPAIR PROTEIN
REV1
(Saccharomyces
cerevisiae) 		5 / 11 PHE A 633
ASP A 640
LEU A 316
PHE A 315
ILE A 627
 None
None
None
EDO  A 815 ( 4.8A)
None
 1.21A 3ko0A-5wmbA:
undetectable
3ko0B-5wmbA:
undetectable
3ko0C-5wmbA:
undetectable
3ko0D-5wmbA:
undetectable		 3ko0A-5wmbA:
13.36
3ko0B-5wmbA:
13.36
3ko0C-5wmbA:
13.36
3ko0D-5wmbA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE202_1
(PROTEIN S100-A4)		 5wmb DNA REPAIR PROTEIN
REV1
(Saccharomyces
cerevisiae) 		5 / 11 ASP A 640
PHE A 633
LEU A 316
PHE A 315
ILE A 627
 None
None
None
EDO  A 815 ( 4.8A)
None
 1.24A 3ko0C-5wmbA:
undetectable
3ko0D-5wmbA:
undetectable
3ko0E-5wmbA:
undetectable
3ko0F-5wmbA:
undetectable		 3ko0C-5wmbA:
13.36
3ko0D-5wmbA:
13.36
3ko0E-5wmbA:
13.36
3ko0F-5wmbA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL202_1
(PROTEIN S100-A4)		 5wmb DNA REPAIR PROTEIN
REV1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 316
PHE A 315
ILE A 627
ASP A 640
PHE A 633
 None
EDO  A 815 ( 4.8A)
None
None
None
 1.19A 3ko0K-5wmbA:
undetectable
3ko0L-5wmbA:
undetectable
3ko0M-5wmbA:
undetectable
3ko0N-5wmbA:
undetectable		 3ko0K-5wmbA:
13.36
3ko0L-5wmbA:
13.36
3ko0M-5wmbA:
13.36
3ko0N-5wmbA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_N_TFPN202_1
(PROTEIN S100-A4)		 5wmb DNA REPAIR PROTEIN
REV1
(Saccharomyces
cerevisiae) 		5 / 11 ASP A 640
PHE A 633
LEU A 316
PHE A 315
ILE A 627
 None
None
None
EDO  A 815 ( 4.8A)
None
 1.23A 3ko0K-5wmbA:
undetectable
3ko0L-5wmbA:
undetectable
3ko0M-5wmbA:
undetectable
3ko0N-5wmbA:
undetectable		 3ko0K-5wmbA:
13.36
3ko0L-5wmbA:
13.36
3ko0M-5wmbA:
13.36
3ko0N-5wmbA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		 5wmb DNA REPAIR PROTEIN
REV1
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 489
CYH A 490
PHE A 359
TYR A 529
 None
 0.86A 4j7uD-5wmbA:
undetectable		 4j7uD-5wmbA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA602_1
(SERUM ALBUMIN)		 5wmb DNA REPAIR PROTEIN
REV1
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 545
LEU A 519
SER A 538
LEU A 537
SER A 511
 None
 1.48A 4zbrA-5wmbA:
undetectable		 4zbrA-5wmbA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5wmb DNA REPAIR PROTEIN
REV1
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 734
ASN A 733
SER A 694
 None
 1.29A 5yw0A-5wmbA:
undetectable		 5yw0A-5wmbA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMM_A_SALA303_0
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		 5wmb DNA REPAIR PROTEIN
REV1
(Saccharomyces
cerevisiae) 		5 / 9 VAL A 391
TYR A 436
ASN A 414
LEU A 325
LEU A 328
 None
None
DCP  A 804 (-3.4A)
None
DCP  A 804 (-4.6A)
 1.34A 6emmA-5wmbA:
0.0		 6emmA-5wmbA:
11.17