SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wml'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3004_1
(SERUM ALBUMIN)		 5wml -
(-) 		4 / 7 PHE A 288
GLU A 255
LEU A 253
LEU A 236
 None
 0.98A 1hk3A-5wmlA:
undetectable		 1hk3A-5wmlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NCW_H_BEZH601_0
(IMMUNOGLOBULIN IGG2A)		 5wml -
(-) 		5 / 9 ALA A 144
LEU A 141
GLY A 347
GLY A 316
TYR A 317
 None
 1.42A 1ncwH-5wmlA:
undetectable
1ncwL-5wmlA:
undetectable		 1ncwH-5wmlA:
undetectable
1ncwL-5wmlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVU_A_PRLA196_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 5wml -
(-) 		4 / 6 LEU A 351
GLU A 152
THR A 300
TYR A 317
 None
 1.41A 1qvuA-5wmlA:
undetectable		 1qvuA-5wmlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 5wml -
(-) 		5 / 9 ALA A 144
LEU A 141
GLY A 347
GLY A 316
TYR A 317
 None
 1.36A 1ru9H-5wmlA:
undetectable
1ru9L-5wmlA:
undetectable		 1ru9H-5wmlA:
undetectable
1ru9L-5wmlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUA_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 5wml -
(-) 		5 / 10 ALA A 144
LEU A 141
GLY A 347
GLY A 316
TYR A 317
 None
 1.38A 1ruaH-5wmlA:
undetectable
1ruaL-5wmlA:
undetectable		 1ruaH-5wmlA:
undetectable
1ruaL-5wmlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUL_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 5wml -
(-) 		5 / 9 ALA A 144
LEU A 141
GLY A 347
GLY A 316
TYR A 317
 None
 1.35A 1rulH-5wmlA:
undetectable
1rulL-5wmlA:
undetectable		 1rulH-5wmlA:
undetectable
1rulL-5wmlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 5wml -
(-) 		3 / 3 GLY A 167
GLY A 303
GLY A 316
 PMP  A 501 (-3.4A)
None
None
 0.38A 3bogD-5wmlA:
undetectable		 3bogD-5wmlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP9_D_SPMD230_1
(LS-24)		 5wml -
(-) 		3 / 3 GLU A 273
GLU A 152
ASN A 153
 None
 0.82A 3lp9B-5wmlA:
undetectable
3lp9D-5wmlA:
undetectable		 3lp9B-5wmlA:
undetectable
3lp9D-5wmlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_A_ACTA207_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 5wml -
(-) 		4 / 7 GLU A 273
LEU A 155
THR A 298
ALA A 289
 None
 1.32A 3mbgA-5wmlA:
undetectable
3mbgB-5wmlA:
undetectable		 3mbgA-5wmlA:
undetectable
3mbgB-5wmlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)		 5wml -
(-) 		4 / 8 THR A  84
GLY A 435
PHE A 438
SER A 418
 GLU  A 502 (-3.5A)
None
None
None
 1.03A 3tzfB-5wmlA:
undetectable		 3tzfB-5wmlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5wml -
(-) 		5 / 12 LEU A 253
LEU A 219
ILE A 260
SER A 247
PRO A 191
 None
 1.36A 3w1wA-5wmlA:
undetectable		 3w1wA-5wmlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5wml -
(-) 		5 / 12 ILE A 274
ILE A 237
VAL A 186
LEU A 235
VAL A 179
 PMP  A 501 ( 4.7A)
None
None
None
None
 1.17A 3w68C-5wmlA:
undetectable		 3w68C-5wmlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZMD_A_SALA201_1
(PUTATIVE
TRANSCRIPTIONAL
REGULATOR)		 5wml -
(-) 		4 / 8 ARG A 297
LEU A 268
ARG A 234
HIS A 323
 None
 1.08A 3zmdA-5wmlA:
undetectable
3zmdB-5wmlA:
undetectable		 3zmdA-5wmlA:
undetectable
3zmdB-5wmlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5wml -
(-) 		5 / 12 LEU A 379
LEU A 375
ILE A 398
SER A 451
VAL A 430
 None
 1.25A 4f4dB-5wmlA:
2.7		 4f4dB-5wmlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTS_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 5wml -
(-) 		5 / 12 PHE A 397
GLY A 246
ILE A 214
ASN A 217
PRO A 191
 None
 1.15A 4rtsA-5wmlA:
5.3		 4rtsA-5wmlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA845_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5wml -
(-) 		4 / 8 MET A 364
ALA A 350
LEU A 353
GLY A 358
 None
 0.88A 4xk8a-5wmlA:
undetectable		 4xk8a-5wmlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CR1_A_T44A201_1
(TRANSTHYRETIN)		 5wml -
(-) 		4 / 5 LEU A 177
ALA A 175
LEU A 331
VAL A 301
 None
 1.01A 5cr1A-5wmlA:
undetectable		 5cr1A-5wmlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J6H_A_NCAA402_0
(H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, Q10 ALPHA
CHAIN)		 5wml -
(-) 		3 / 3 PRO A 159
ARG A 142
GLU A 143
 None
 0.87A 5j6hA-5wmlA:
undetectable		 5j6hA-5wmlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_A_FLPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5wml -
(-) 		5 / 12 TYR A 275
GLY A 167
ALA A 168
SER A 171
LEU A 172
 PMP  A 501 (-4.3A)
PMP  A 501 (-3.4A)
PMP  A 501 (-3.6A)
None
None
 1.08A 5jvzA-5wmlA:
undetectable		 5jvzA-5wmlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_B_FLPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5wml -
(-) 		5 / 12 TYR A 275
GLY A 167
ALA A 168
SER A 171
LEU A 172
 PMP  A 501 (-4.3A)
PMP  A 501 (-3.4A)
PMP  A 501 (-3.6A)
None
None
 1.09A 5jvzB-5wmlA:
undetectable		 5jvzB-5wmlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5wml -
(-) 		5 / 12 ALA A 350
GLY A 167
ALA A 168
SER A 171
LEU A 172
 None
PMP  A 501 (-3.4A)
PMP  A 501 (-3.6A)
None
None
 0.95A 5kirB-5wmlA:
undetectable		 5kirB-5wmlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5wml -
(-) 		5 / 12 ILE A 274
GLY A 303
VAL A 164
GLN A 170
TYR A 196
 PMP  A 501 ( 4.7A)
None
None
None
None
 1.17A 5n0xB-5wmlA:
2.9		 5n0xB-5wmlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_1
(SCRFP-TAG,GP41)		 5wml -
(-) 		5 / 12 LEU A 315
GLY A 167
LYS A 169
LEU A 163
LEU A 318
 None
PMP  A 501 (-3.4A)
GLU  A 502 ( 2.3A)
None
None
 1.26A 5nwvA-5wmlA:
undetectable		 5nwvA-5wmlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		 5wml -
(-) 		4 / 6 ALA A 319
PRO A 321
VAL A 325
TYR A 157
 None
 1.18A 5umd2-5wmlA:
undetectable
5umdF-5wmlA:
undetectable		 5umd2-5wmlA:
undetectable
5umdF-5wmlA:
undetectable