SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wmm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_2
(HIV-1 PROTEASE)		 5wmm NRPS
(Micromonospora
sp.
ML1) 		3 / 3 ARG A 392
THR A 311
VAL A 366
 None
 0.82A 1hxbA-5wmmA:
undetectable		 1hxbA-5wmmA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		 5wmm NRPS
(Micromonospora
sp.
ML1) 		4 / 5 TYR A 217
LEU A 285
THR A 301
ARG A 319
 None
None
None
CA  A1006 (-4.0A)
 1.30A 1i2wA-5wmmA:
undetectable		 1i2wA-5wmmA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M8E_B_H4BB903_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 5wmm NRPS
(Micromonospora
sp.
ML1) 		3 / 3 ARG A 721
ILE A 514
TRP A 505
 None
 1.22A 1m8eB-5wmmA:
undetectable		 1m8eB-5wmmA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_A_SAMA300_0
(HEMK PROTEIN)		 5wmm NRPS
(Micromonospora
sp.
ML1) 		5 / 12 ILE A 541
GLY A 542
GLY A 544
THR A 562
ASN A 610
 None
SAH  A1002 (-3.7A)
SAH  A1002 (-3.4A)
None
SAH  A1002 (-3.7A)
 0.69A 1nv8A-5wmmA:
11.7		 1nv8A-5wmmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OVF_B_DVAB2_0
(ACTINOMYCIN D)		 5wmm NRPS
(Micromonospora
sp.
ML1) 		3 / 3 THR A 313
PRO A 308
THR A 309
 None
B6G  A1001 (-4.5A)
B6G  A1001 (-3.8A)
 0.85A 1ovfB-5wmmA:
undetectable		 1ovfB-5wmmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_A_MTXA351_1
(PTERIDINE REDUCTASE
1)		 5wmm NRPS
(Micromonospora
sp.
ML1) 		5 / 12 PHE A  39
LEU A  66
TYR A  63
LEU A 106
PRO A  36
 None
 1.39A 1p33A-5wmmA:
3.6		 1p33A-5wmmA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5wmm NRPS
(Micromonospora
sp.
ML1) 		4 / 4 ALA A 854
VAL A 858
ALA A 855
HIS A 476
 None
 1.17A 1q23A-5wmmA:
undetectable		 1q23A-5wmmA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5wmm NRPS
(Micromonospora
sp.
ML1) 		4 / 4 ALA A 854
VAL A 858
ALA A 855
HIS A 476
 None
 1.12A 1q23F-5wmmA:
undetectable		 1q23F-5wmmA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5wmm NRPS
(Micromonospora
sp.
ML1) 		4 / 4 ALA A 854
VAL A 858
ALA A 855
HIS A 476
 None
 1.16A 1q23K-5wmmA:
undetectable		 1q23K-5wmmA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TBF_A_VIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5wmm NRPS
(Micromonospora
sp.
ML1) 		5 / 9 TYR A 112
LEU A 224
VAL A 102
ALA A 101
LEU A  66
 None
 1.20A 1tbfA-5wmmA:
undetectable		 1tbfA-5wmmA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DXR_A_SORA1002_0
(LACTOTRANSFERRIN)		 5wmm NRPS
(Micromonospora
sp.
ML1) 		3 / 3 THR A 692
PRO A 688
TYR A 838
 None
 0.88A 2dxrA-5wmmA:
1.8		 2dxrA-5wmmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8G_B_017B401_1
(POL POLYPROTEIN)		 5wmm NRPS
(Micromonospora
sp.
ML1) 		5 / 12 LEU A 726
ASP A 631
VAL A 607
VAL A 641
ILE A 639
 None
 1.02A 2f8gA-5wmmA:
undetectable		 2f8gA-5wmmA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 5wmm NRPS
(Micromonospora
sp.
ML1) 		5 / 12 GLY A 544
GLY A 561
LEU A 547
LEU A 548
THR A 503
 SAH  A1002 (-3.4A)
None
SAH  A1002 (-3.7A)
SAH  A1002 ( 4.7A)
None
 0.99A 2nyuB-5wmmA:
11.1		 2nyuB-5wmmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 5wmm NRPS
(Micromonospora
sp.
ML1) 		3 / 3 ARG A 392
THR A 311
VAL A 366
 None
 0.85A 2qakA-5wmmA:
undetectable		 2qakA-5wmmA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 5wmm NRPS
(Micromonospora
sp.
ML1) 		3 / 3 ASN A 186
ARG A 185
ASP A 384
 None
 0.97A 2qe6A-5wmmA:
12.5		 2qe6A-5wmmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 5wmm NRPS
(Micromonospora
sp.
ML1) 		3 / 3 ASN A 186
ARG A 185
ASP A 384
 None
 0.95A 2qe6B-5wmmA:
12.5		 2qe6B-5wmmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 5wmm NRPS
(Micromonospora
sp.
ML1) 		4 / 6 PHE A  39
TRP A 220
GLY A 227
GLY A 226
 None
 1.01A 2qr2A-5wmmA:
undetectable
2qr2B-5wmmA:
undetectable		 2qr2A-5wmmA:
15.14
2qr2B-5wmmA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_A_ACTA1397_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 5wmm NRPS
(Micromonospora
sp.
ML1) 		3 / 3 PRO A 827
GLY A 763
TYR A 807
 None
 0.69A 2vouA-5wmmA:
undetectable		 2vouA-5wmmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_A_IBPA1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 5wmm NRPS
(Micromonospora
sp.
ML1) 		4 / 7 GLY A 282
GLY A 307
THR A 309
ARG A 424
 B6G  A1001 (-3.4A)
B6G  A1001 (-4.8A)
B6G  A1001 (-3.8A)
B6G  A1001 (-4.0A)
 0.34A 2wd9A-5wmmA:
39.0		 2wd9A-5wmmA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_B_IBPB1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 5wmm NRPS
(Micromonospora
sp.
ML1) 		4 / 8 GLY A 282
GLY A 307
THR A 309
ARG A 424
 B6G  A1001 (-3.4A)
B6G  A1001 (-4.8A)
B6G  A1001 (-3.8A)
B6G  A1001 (-4.0A)
 0.31A 2wd9B-5wmmA:
40.6		 2wd9B-5wmmA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_C_IBPC1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 5wmm NRPS
(Micromonospora
sp.
ML1) 		5 / 10 THR A 170
GLY A 282
GLY A 307
THR A 309
ARG A 424
 None
B6G  A1001 (-3.4A)
B6G  A1001 (-4.8A)
B6G  A1001 (-3.8A)
B6G  A1001 (-4.0A)
 0.37A 2wd9C-5wmmA:
40.2		 2wd9C-5wmmA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AMU_A_AG2A422_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 5wmm NRPS
(Micromonospora
sp.
ML1) 		4 / 5 GLU A 162
ASN A 186
VAL A 366
ARG A 185
 None
 1.44A 3amuA-5wmmA:
undetectable		 3amuA-5wmmA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E68_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5wmm NRPS
(Micromonospora
sp.
ML1) 		3 / 3 ARG A 721
ILE A 514
TRP A 505
 None
 1.17A 3e68A-5wmmA:
undetectable		 3e68A-5wmmA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E6T_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5wmm NRPS
(Micromonospora
sp.
ML1) 		3 / 3 ARG A 721
ILE A 514
TRP A 505
 None
 1.19A 3e6tB-5wmmA:
undetectable		 3e6tB-5wmmA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5wmm NRPS
(Micromonospora
sp.
ML1) 		4 / 8 TYR A 370
ASN A 372
HIS A 373
GLY A 172
 None
 0.84A 3em0B-5wmmA:
undetectable		 3em0B-5wmmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FBX_A_ACTA608_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2)		 5wmm NRPS
(Micromonospora
sp.
ML1) 		3 / 3 GLU A 778
VAL A 657
CYH A 782
 None
 1.05A 3fbxA-5wmmA:
undetectable		 3fbxA-5wmmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 5wmm NRPS
(Micromonospora
sp.
ML1) 		5 / 12 GLY A 542
GLY A 544
PHE A 564
VAL A 612
TYR A 615
 SAH  A1002 (-3.7A)
SAH  A1002 (-3.4A)
SAH  A1002 (-3.4A)
SAH  A1002 (-4.3A)
SAH  A1002 (-4.8A)
 0.70A 3o7wA-5wmmA:
12.2		 3o7wA-5wmmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		 5wmm NRPS
(Micromonospora
sp.
ML1) 		4 / 5 GLY A 298
ASP A 297
ARG A 295
GLN A 274
 None
 1.03A 3qx3A-5wmmA:
undetectable		 3qx3A-5wmmA:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_D_EVPD1_1
(DNA TOPOISOMERASE
2-BETA)		 5wmm NRPS
(Micromonospora
sp.
ML1) 		4 / 5 GLY A 298
ASP A 297
ARG A 295
GLN A 274
 None
 1.06A 3qx3B-5wmmA:
undetectable		 3qx3B-5wmmA:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKW_B_017B401_1
(PROTEASE)		 5wmm NRPS
(Micromonospora
sp.
ML1) 		5 / 12 LEU A 726
ASP A 631
VAL A 607
VAL A 641
ILE A 639
 None
 0.99A 3tkwA-5wmmA:
undetectable		 3tkwA-5wmmA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5wmm NRPS
(Micromonospora
sp.
ML1) 		3 / 3 THR A 396
VAL A 361
GLU A 310
 None
 0.78A 3v4tA-5wmmA:
1.8
3v4tD-5wmmA:
1.6		 3v4tA-5wmmA:
undetectable
3v4tD-5wmmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VNS_A_DVAA602_0
(NRPS ADENYLATION
PROTEIN CYTC1)		 5wmm NRPS
(Micromonospora
sp.
ML1) 		5 / 7 ASP A 213
GLY A 282
THR A 309
PHE A 314
LYS A 419
 B6G  A1001 (-2.7A)
B6G  A1001 (-3.4A)
B6G  A1001 (-3.8A)
B6G  A1001 ( 4.7A)
B6G  A1001 (-3.0A)
 1.03A 3vnsA-5wmmA:
47.2		 3vnsA-5wmmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VNS_A_DVAA602_0
(NRPS ADENYLATION
PROTEIN CYTC1)		 5wmm NRPS
(Micromonospora
sp.
ML1) 		5 / 7 PHE A 212
ASP A 213
GLY A 282
THR A 309
PHE A 314
 CA  A1008 (-4.2A)
B6G  A1001 (-2.7A)
B6G  A1001 (-3.4A)
B6G  A1001 (-3.8A)
B6G  A1001 ( 4.7A)
 0.52A 3vnsA-5wmmA:
47.2		 3vnsA-5wmmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 5wmm NRPS
(Micromonospora
sp.
ML1) 		4 / 6 PHE A 261
ALA A 289
LEU A 293
VAL A 294
 None
 0.98A 4dubA-5wmmA:
undetectable		 4dubA-5wmmA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_SAMA301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5wmm NRPS
(Micromonospora
sp.
ML1) 		5 / 12 GLY A 542
GLY A 544
SER A 565
ALA A 593
VAL A 612
 SAH  A1002 (-3.7A)
SAH  A1002 (-3.4A)
SAH  A1002 ( 4.9A)
SAH  A1002 (-3.6A)
SAH  A1002 (-4.3A)
 0.55A 4htfA-5wmmA:
15.7		 4htfA-5wmmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_B_SAMB301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5wmm NRPS
(Micromonospora
sp.
ML1) 		5 / 12 GLY A 542
GLY A 544
SER A 565
ALA A 593
VAL A 612
 SAH  A1002 (-3.7A)
SAH  A1002 (-3.4A)
SAH  A1002 ( 4.9A)
SAH  A1002 (-3.6A)
SAH  A1002 (-4.3A)
 0.58A 4htfB-5wmmA:
15.4		 4htfB-5wmmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVR_A_SALA203_1
(3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE)		 5wmm NRPS
(Micromonospora
sp.
ML1) 		4 / 7 ASP A 200
GLU A 277
HIS A 201
VAL A 303
 CA  A1006 (-3.4A)
CA  A1006 (-3.3A)
None
None
 0.97A 4hvrA-5wmmA:
undetectable		 4hvrA-5wmmA:
26.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_A_SAMA900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 5wmm NRPS
(Micromonospora
sp.
ML1) 		5 / 12 TYR A 484
GLY A 542
GLY A 544
SER A 565
ALA A 593
 SAH  A1002 ( 3.8A)
SAH  A1002 (-3.7A)
SAH  A1002 (-3.4A)
SAH  A1002 ( 4.9A)
SAH  A1002 (-3.6A)
 0.85A 4krhA-5wmmA:
16.8		 4krhA-5wmmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_1
(NEURAMINIDASE)		 5wmm NRPS
(Micromonospora
sp.
ML1) 		3 / 3 ARG A 448
ASP A 881
ARG A 451
 None
 0.86A 4mx0A-5wmmA:
undetectable		 4mx0A-5wmmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_A_FK5A205_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 5wmm NRPS
(Micromonospora
sp.
ML1) 		4 / 4 THR A 812
ARG A 766
GLU A 822
VAL A 837
 None
 1.40A 4odoC-5wmmA:
0.0		 4odoC-5wmmA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 5wmm NRPS
(Micromonospora
sp.
ML1) 		5 / 12 TYR A 484
GLY A 542
GLY A 544
LEU A 547
SER A 565
 SAH  A1002 ( 3.8A)
SAH  A1002 (-3.7A)
SAH  A1002 (-3.4A)
SAH  A1002 (-3.7A)
SAH  A1002 ( 4.9A)
 0.83A 4qtuB-5wmmA:
14.4		 4qtuB-5wmmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TZC_D_EF2D505_1
(PROTEIN CEREBLON)		 5wmm NRPS
(Micromonospora
sp.
ML1) 		4 / 8 TYR A 217
THR A 216
HIS A 225
TRP A 279
 None
 1.46A 4tzcB-5wmmA:
undetectable
4tzcD-5wmmA:
undetectable		 4tzcB-5wmmA:
15.74
4tzcD-5wmmA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4USW_A_ACTA1470_0
(ADENYLATE CYCLASE
TYPE 10)		 5wmm NRPS
(Micromonospora
sp.
ML1) 		4 / 6 LEU A 877
VAL A 878
ARG A 421
PHE A 423
 None
None
None
CA  A1008 ( 4.4A)
 1.06A 4uswA-5wmmA:
undetectable		 4uswA-5wmmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		 5wmm NRPS
(Micromonospora
sp.
ML1) 		4 / 6 VAL A 724
LEU A 622
ILE A 686
ALA A 695
 None
 0.63A 4zf8A-5wmmA:
undetectable		 4zf8A-5wmmA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		 5wmm NRPS
(Micromonospora
sp.
ML1) 		4 / 7 PHE A 212
ASP A 213
GLY A 282
THR A 309
 CA  A1008 (-4.2A)
B6G  A1001 (-2.7A)
B6G  A1001 (-3.4A)
B6G  A1001 (-3.8A)
 0.36A 4zxiA-5wmmA:
44.0		 4zxiA-5wmmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA202_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 5wmm NRPS
(Micromonospora
sp.
ML1) 		4 / 8 HIS A 727
GLY A 636
GLY A 637
VAL A 702
 None
 0.71A 5f8yA-5wmmA:
undetectable		 5f8yA-5wmmA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB201_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 5wmm NRPS
(Micromonospora
sp.
ML1) 		4 / 8 HIS A 727
GLY A 636
GLY A 637
VAL A 702
 None
 0.74A 5f8yB-5wmmA:
undetectable		 5f8yB-5wmmA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_B_FUAB1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5wmm NRPS
(Micromonospora
sp.
ML1) 		4 / 5 ILE A 137
LEU A 131
HIS A  86
VAL A  82
 None
 1.11A 5jmnB-5wmmA:
2.1		 5jmnB-5wmmA:
6.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA612_1
(PHIAB6 TAILSPIKE)		 5wmm NRPS
(Micromonospora
sp.
ML1) 		4 / 4 VAL A 739
THR A 741
GLU A 816
GLU A 822
 None
 1.20A 5jsdA-5wmmA:
0.8
5jsdB-5wmmA:
0.7		 5jsdA-5wmmA:
8.90
5jsdB-5wmmA:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_C_1GNC611_1
(PHIAB6 TAILSPIKE)		 5wmm NRPS
(Micromonospora
sp.
ML1) 		4 / 4 GLU A 816
GLU A 822
VAL A 739
THR A 741
 None
 1.20A 5jsdA-5wmmA:
0.8
5jsdC-5wmmA:
0.6		 5jsdA-5wmmA:
8.90
5jsdC-5wmmA:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 5wmm NRPS
(Micromonospora
sp.
ML1) 		5 / 12 GLY A 109
GLY A  83
ASP A 158
VAL A 159
ALA A  74
 None
 1.11A 5kpcB-5wmmA:
12.9		 5kpcB-5wmmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M67_C_ACTC504_0
(ADENOSYLHOMOCYSTEINA
SE)		 5wmm NRPS
(Micromonospora
sp.
ML1) 		4 / 4 ASP A 138
ILE A 137
ARG A  80
ARG A 140
 None
 1.45A 5m67C-5wmmA:
5.4		 5m67C-5wmmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N9X_A_THRA601_0
(ADENYLATION DOMAIN)		 5wmm NRPS
(Micromonospora
sp.
ML1) 		4 / 7 PHE A 212
ASP A 213
GLY A 282
GLY A 307
 CA  A1008 (-4.2A)
B6G  A1001 (-2.7A)
B6G  A1001 (-3.4A)
B6G  A1001 (-4.8A)
 0.56A 5n9xA-5wmmA:
47.8		 5n9xA-5wmmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NY7_A_NCAA303_0
(AMIDASE)		 5wmm NRPS
(Micromonospora
sp.
ML1) 		4 / 6 ARG A 839
THR A 812
GLU A 822
SER A 814
 None
 1.10A 5ny7A-5wmmA:
undetectable		 5ny7A-5wmmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH1_C_9UQC202_0
(CEREBLON ISOFORM 4)		 5wmm NRPS
(Micromonospora
sp.
ML1) 		4 / 8 PRO A 222
GLU A 218
TRP A 220
TYR A 112
 None
 1.33A 5oh1C-5wmmA:
undetectable		 5oh1C-5wmmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		 5wmm NRPS
(Micromonospora
sp.
ML1) 		4 / 6 ALA A 854
PRO A 463
VAL A 858
ASP A 472
 None
 1.13A 5umd2-5wmmA:
undetectable
5umdF-5wmmA:
undetectable		 5umd2-5wmmA:
21.59
5umdF-5wmmA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7J_A_TESA502_0
(CYTOCHROME P450)		 5wmm NRPS
(Micromonospora
sp.
ML1) 		4 / 7 LEU A  97
ALA A 100
ALA A 101
THR A 105
 None
 0.82A 6a7jA-5wmmA:
undetectable		 6a7jA-5wmmA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 5wmm NRPS
(Micromonospora
sp.
ML1) 		5 / 12 TYR A 318
VAL A 275
PHE A 261
LEU A 285
VAL A 290
 None
 1.33A 6a93B-5wmmA:
undetectable		 6a93B-5wmmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AGG_Z_AG2Z503_0
(TRNA(ILE2)
2-AGMATINYLCYTIDINE
SYNTHETASE TIAS)		 5wmm NRPS
(Micromonospora
sp.
ML1) 		4 / 5 GLU A 162
ASN A 186
VAL A 366
ARG A 185
 None
 1.40A 6aggZ-5wmmA:
undetectable		 6aggZ-5wmmA:
26.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DHB_A_BEZA202_0
(HEPATITIS A VIRUS
CELLULAR RECEPTOR 2)		 5wmm NRPS
(Micromonospora
sp.
ML1) 		4 / 6 ARG A 521
ILE A 514
ASN A 715
ASP A 713
 None
 1.33A 6dhbA-5wmmA:
undetectable		 6dhbA-5wmmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_A_ACRA801_2
(GLUCOAMYLASE P)		 5wmm NRPS
(Micromonospora
sp.
ML1) 		3 / 3 TRP A 505
GLU A 716
GLU A 683
 None
 1.01A 6fhwA-5wmmA:
undetectable		 6fhwA-5wmmA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 5wmm NRPS
(Micromonospora
sp.
ML1) 		5 / 10 ALA A 134
VAL A  88
ILE A  73
ALA A  74
ALA A  79
 None
 1.30A 6h1lA-5wmmA:
undetectable		 6h1lA-5wmmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_E_PCFE202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5wmm NRPS
(Micromonospora
sp.
ML1) 		4 / 8 ILE A 246
ALA A 232
VAL A 231
ARG A 249
 None
 1.05A 6hu9a-5wmmA:
undetectable
6hu9e-5wmmA:
undetectable		 6hu9a-5wmmA:
undetectable
6hu9e-5wmmA:
undetectable