SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wnn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB6_0
(GRAMICIDIN A)		 5wnn PHOSPHATE-BINDING
PROTEIN PSTS
(Burkholderia
pseudomallei) 		3 / 3 TRP A 328
ALA A 339
VAL A 332
 None
 0.89A 1bdwA-5wnnA:
undetectable
1bdwB-5wnnA:
undetectable		 1bdwA-5wnnA:
5.56
1bdwB-5wnnA:
5.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_B_SAMB301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 5wnn PHOSPHATE-BINDING
PROTEIN PSTS
(Burkholderia
pseudomallei) 		5 / 12 GLY A 196
GLY A 194
VAL A 214
GLU A 215
ALA A 202
 None
 0.93A 1vq1B-5wnnA:
undetectable		 1vq1B-5wnnA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_A_ACTA2001_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 5wnn PHOSPHATE-BINDING
PROTEIN PSTS
(Burkholderia
pseudomallei) 		4 / 5 TYR A 213
SER A 159
SER A 162
ASN A 197
 None
PO4  A 400 (-2.5A)
None
PO4  A 400 ( 4.6A)
 1.30A 1yvpA-5wnnA:
undetectable		 1yvpA-5wnnA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_B_SAMB500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 5wnn PHOSPHATE-BINDING
PROTEIN PSTS
(Burkholderia
pseudomallei) 		5 / 11 VAL A 102
THR A 227
PRO A 239
ALA A 217
ASP A  76
 None
None
None
None
PO4  A 400 (-3.0A)
 1.28A 2admB-5wnnA:
undetectable		 2admB-5wnnA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_B_SAMB500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 5wnn PHOSPHATE-BINDING
PROTEIN PSTS
(Burkholderia
pseudomallei) 		5 / 11 VAL A 102
THR A 227
PRO A 239
GLU A 215
ALA A 217
 None
 1.27A 2admB-5wnnA:
undetectable		 2admB-5wnnA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_3
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 5wnn PHOSPHATE-BINDING
PROTEIN PSTS
(Burkholderia
pseudomallei) 		5 / 12 PHE A  31
GLY A 160
LEU A 169
VAL A 100
TYR A 213
 None
PO4  A 400 (-3.6A)
None
None
None
 1.41A 2nyrB-5wnnA:
undetectable		 2nyrB-5wnnA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA2_0
(FERROCHELATASE)		 5wnn PHOSPHATE-BINDING
PROTEIN PSTS
(Burkholderia
pseudomallei) 		4 / 6 ARG A 155
PRO A 239
GLY A  98
TRP A 270
 PO4  A 400 (-2.8A)
None
None
None
 1.45A 3aqiA-5wnnA:
undetectable		 3aqiA-5wnnA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA2_0
(FERROCHELATASE)		 5wnn PHOSPHATE-BINDING
PROTEIN PSTS
(Burkholderia
pseudomallei) 		4 / 6 MET A 224
ARG A 155
PRO A 239
GLY A  98
 None
PO4  A 400 (-2.8A)
None
None
 1.41A 3aqiA-5wnnA:
undetectable		 3aqiA-5wnnA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I45_A_NIOA500_1
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN)		 5wnn PHOSPHATE-BINDING
PROTEIN PSTS
(Burkholderia
pseudomallei) 		4 / 8 PHE A 297
LEU A 294
PHE A  72
LEU A 280
 None
 1.01A 3i45A-5wnnA:
2.1		 3i45A-5wnnA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_H_TRUH800_1
(GLUTAMATE RECEPTOR 2)		 5wnn PHOSPHATE-BINDING
PROTEIN PSTS
(Burkholderia
pseudomallei) 		3 / 3 ILE A  65
SER A  75
SER A  59
 None
 0.50A 3iltH-5wnnA:
5.0		 3iltH-5wnnA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 5wnn PHOSPHATE-BINDING
PROTEIN PSTS
(Burkholderia
pseudomallei) 		5 / 12 ALA A  40
PHE A 297
PHE A 296
PHE A  92
THR A  94
 None
 1.39A 4iaqA-5wnnA:
undetectable		 4iaqA-5wnnA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_F_CAMF502_0
(CAMPHOR
5-MONOOXYGENASE)		 5wnn PHOSPHATE-BINDING
PROTEIN PSTS
(Burkholderia
pseudomallei) 		4 / 4 TYR A 124
THR A 192
VAL A 200
ILE A 211
 None
 1.48A 4jx1F-5wnnA:
undetectable		 4jx1F-5wnnA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_2
(NEURAMINIDASE)		 5wnn PHOSPHATE-BINDING
PROTEIN PSTS
(Burkholderia
pseudomallei) 		4 / 5 LEU A 145
ASP A 133
TRP A 131
ILE A 123
 None
 1.03A 4mwrA-5wnnA:
undetectable		 4mwrA-5wnnA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5wnn PHOSPHATE-BINDING
PROTEIN PSTS
(Burkholderia
pseudomallei) 		4 / 5 ALA A 300
ARG A 325
ALA A 305
GLU A 321
 None
 1.38A 5a06C-5wnnA:
undetectable
5a06D-5wnnA:
undetectable		 5a06C-5wnnA:
22.66
5a06D-5wnnA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5wnn PHOSPHATE-BINDING
PROTEIN PSTS
(Burkholderia
pseudomallei) 		4 / 5 GLY A 234
THR A 233
GLY A 107
LEU A 115
 None
 0.93A 5jlcA-5wnnA:
undetectable		 5jlcA-5wnnA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1103_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 5wnn PHOSPHATE-BINDING
PROTEIN PSTS
(Burkholderia
pseudomallei) 		4 / 8 THR A 184
TYR A 213
VAL A 200
GLY A 194
 None
 0.93A 5nzyA-5wnnA:
undetectable		 5nzyA-5wnnA:
21.74